99Tcm-MIBI用于乳腺癌诊断的评价

何建华

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99Tcm-MIBI用于乳腺癌诊断的评价

    作者简介: 何建华(1963年-),男,重庆市人,主任,主要从事临床核医学珍断和治疗研究。;
  • 中图分类号: R737.9;R817.4

Evaluation of 99Tcm-MIBI scintigraphy in the diagnosis of breast cancer

  • CLC number: R737.9;R817.4

  • 摘要: 99Tcm-MIBI(9Tcm-甲氧基异丁基异腈)用于乳腺癌原发病灶诊断具有较高的灵敏度、特异性和准确率,与其他检测技术的对比研究显示其具有良好的应用前景,与其他检测技术联合应用可进一步提高诊断的准确性。
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    [5] Cordobes MD,Starzec A,Delmon-Moingeon L, et al. Technetium-99m-ses tamibi uptake by human benign and malignant breast tumor cells:Correlation with mdr gene expression[J].J Nucl Med,1996,37:286-289.
    [6] Yoon JH,Bom HS,Song HC, et al. Double-phase Tc-99m sestamibi scintimammography to assess angiogenesis and Pglycoprotein expression in patients with untreated breast cancer[J].Clin Nucl Med,1999,24(5):314-318.
    [7] Kao CH,Tsai SC,Liu TG, et al. P-glycoprotein and multidrug resistance-related protein expressions in relation to technetium 99m MIBI scintimammography findings[J].Cancer Res,2001,15(61):1412-1414.
    [8] Mansi L,Rambaldi PF,Procaccini E, et al. Scintimammography with 99Tcm-tetrofosmin in the diagnosis of breast cancer and lymph node metastases[J].Eur J Nucl Med,1996,23:932-939.
    [9] Akcay MN,Akin Y,Karabag B, et al. 9Tcm-tetrofosmin in breast carcinoma and axillary lymph node metastases:a comparative study with 99Tcm-MIBI[J].Clin Nucl Med,1997,22:832-834.
    [10] Rodrigues M,Chehne F,Kalinowska W, et al. Uptake of 9Tcm-MIBI and 99Tcm-tetrofosmin into malignant versus nonmalignant breast cell lines[J].J Nucl Med,2000,41:1495-1499.
    [11] AMANO S,Inoue T,Tomiyoshi K, et al. In vivo comparison of PET and SPECT radiopharmaceuticals in detecting breast cancer[J].J Nucl Med,1998.1424-1427.
    [12] Palmedo H,Bender H,Grüwald F, et al. Comparison of 18F-FDG PET and 99Tcm-MIBI scintimammography in the detection of breast tumours[J].Eur J Nucl Med,1997,24:1138-1145.
    [13] Inbriaco M,Vecchio SD,Riccardi A, et al. Scintimammography with 99Tcm-MIBI versus dynamic MRI for non-invasive characterization of breast masses[J].Eur J Nucl Med,2001,28:56-63.
    [14] Taillefer R. The role of 99mTc-sestamibi and other conventional radio-pharmaceuticals in breast cancer diagnosis[J].Semin Nucl Med,1999,29:22-23.
    [15] Khalkhali I,Cutrone J,Mena I, et al. Technetium-99m-sestamibi scintimammography of breast lesions:Clin and pathological follow-up[J].J Nucl Med,1995,36:1784-1789.
    [16] Buscombe JR,Cwikla JB,Holloway B, et al. Prediction of the usefulness of combined mammography and scintimammography in suspected primary breast cancer using ROC curves[J].J Nucl Med,2001,42:3-8.
    [17] Buffaz PD,Gauchez AS. Can tumour marker assays be a guide in the prescription of bone scan for breast and lung cancers?[J].Eur J Nucl Med,1999,26:8-11.
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    [2] 贾志云邓候富99Tcm-甲氧基异丁基异腈显像在白血病中的应用价值. 国际放射医学核医学杂志, 2005, 29(6): 252-254.
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    [7] 陈璟吴华 . 乳腺癌前哨淋巴结探查的研究进展. 国际放射医学核医学杂志, 2002, 26(5): 222-224.
    [8] 黄建敏曲雁潘莉萍 . 恶性骨肿瘤多药耐药的99Tcm-MIBI体层显像研究. 国际放射医学核医学杂志, 2005, 29(4): 169-170.
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  • 收稿日期:  2000-02-14

99Tcm-MIBI用于乳腺癌诊断的评价

    作者简介:何建华(1963年-),男,重庆市人,主任,主要从事临床核医学珍断和治疗研究。
  • 402160 重庆, 重庆市第二人民医院核医学科

摘要: 99Tcm-MIBI(9Tcm-甲氧基异丁基异腈)用于乳腺癌原发病灶诊断具有较高的灵敏度、特异性和准确率,与其他检测技术的对比研究显示其具有良好的应用前景,与其他检测技术联合应用可进一步提高诊断的准确性。

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