TPO基因及其应用研究

邢岩

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TPO基因及其应用研究

    作者简介: 邢岩(1977-),女,四川绵阳人,硕士研究生,主要从事分子核医学方面的研究。;
  • 基金项目:

    国家自然科学基金资助项目(30170281)

  • 中图分类号: R817.5;Q554+.6

The research and application of TPO's gene

  • CLC number: R817.5;Q554+.6

  • 摘要: TPO(甲状腺过氧化物酶)是甲状腺细胞膜上的一种糖蛋白,是合成甲状腺激素的关键酶。深入研究其基因结构及转录调控对甲状腺疾病和放射性碘治疗具有重要意义。
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    [2] Niccoli P, Fayadat L, Panneels V, et al. Human thyroperoxidase in its alternatively spliced form (TPO2) is enzymatically inactive and exhibits changes in intracellular processing and trafficking[J]. J Biol Chem, 1997, 272(47):29487-29492.
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    [5] Mariastella Z, Helen FL, Dimitri P, et al. Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters[J]. Mol Cell Biol, 1992, 12(9):4230-4241.
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    [7] Claudio E, Stetania M, Adolfo S, et al. Pax8 activates the enhancer of the human thyroperoxi-dase gene[J]. Biochem J, 1998, 331(1):37-40.
    [8] Gerard CM, Lefort A, Christophe D, et al. Distinct transcriptional effects of cAMP on 2 thyroid specific genes:thyroperoxidase and thyroglobulin[J]. Horm Metab Res buppl, 1990, 23:38-43.
    [9] Penel C, Gruffat D, Alquier C, et al. Thyrotropin chronically regulates the pool of thyropero-xidase and its intra-cellular distribution:a quantitative confocal microscopic study[J]. J Cell Physiol, 1998, 174(2):160-169.
    [10] Napolitano G, Montani V, Giuliani C, et al. Transforming growth factor-betal down-regulation of major histo-compatibility complex class I in thyrocytes:coordinate regulation of two separate elements by thyroid-specific as well as ubiquitous transcription factors[J]. Mol Endocrinol, 2000, 14(4):486-505.
    [11] Miyazaki A, Shimura H, Endo T, et al. Tumor necrosis factor-alpha and interferon-gamma suppress both gene expression and deoxyribonucleic acid-binding of TTF-2 in FRTL-5 cells[J]. Endocrinology, 1999, 140(9):4214-4220.
    [12] Uyttersprot N, Pelgrims N, Carrasco N, et al. Moderate doses of iodide in vivo inhibit cell proliferation and the expression of thyroperoxidase and Na+/I- symporter mRNAs in dog thyroid[J]. Mol Cell Endocrinol, 1997, 131(2):195-203.
    [13] Ortia L, Zannini M, Di-Lauro R, et al. Transcriptional contral of the forkhead thyroid transcription factor TTF-2 by thyrotropin, insulin, and insulin-like growth factor 1[J]. J Biol Chem, 1997, 272(37):23334-23339.
    [14] Da-Costa VM, Moreira DG, Rosenthal D, et al. Thyroid function and aging:gender-related differences[J]. J Endocrinol, 2001, 171(1):193-198.
    [15] Armengol MP, Juan M, Lucas MA, et al. Thyroid autoimmune disease:demon-stration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centers[J]. Am J Pathol, 2001, 159(3):861-873.
    [16] Niedziela M, Korman E. Severe hypothyroidism due to autoimmune atrophic thyroiditis-predicted target height and a plausible mechanism for sexual precocity[J]. J Pediatr Endocrinol Metab, 2001, 14(7):901-907.
    [17] Deleu S, Allory Y, Radulescu A, et al. Characterization of autonomous thyroid adenoma:metabolism, gene expression, and pathology[J]. Thyroid, 2000, 10(2):131-140.
    [18] Ros P, Rossi DL, Acebron A, et al. Thyroid-specific gene expression in the multi-step process of thyroid careino-genesis[J]. Biochimie, 1999, 81(4):389-396.
    [19] Franke WG, Zophel K, Wunderlieh GR, et al. Thyropemxidase:a tumor marker for post-therapeutic follow-up of differentiated thyroid carcinomas? Results of a time course study[J]. Cancer Detect Prey, 2000, 24(6):524-530.
    [20] Geraldo M, Maria J, Cecilia L, et al. Metastatic thyroid carcinoma arising from congenital goiter due to mutation in the thyroperoxidase gene[J]. J Clin Endoerinol Metab, 1998, 83(11):4162-4166.
    [21] Haberkorn U, Altmann A, Jiang S, et al. Iodide uptake in human anaplastic thyroid carcinoma cells after transfer of the human thyroid peroxidase gene[J]. Eur J Nucl Med, 2001, 28(5):633-638.
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  • 收稿日期:  2002-07-23

TPO基因及其应用研究

    作者简介:邢岩(1977-),女,四川绵阳人,硕士研究生,主要从事分子核医学方面的研究。
  • 610041 成都, 四川大学华西医院核医学科
基金项目:  国家自然科学基金资助项目(30170281)

摘要: TPO(甲状腺过氧化物酶)是甲状腺细胞膜上的一种糖蛋白,是合成甲状腺激素的关键酶。深入研究其基因结构及转录调控对甲状腺疾病和放射性碘治疗具有重要意义。

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