正电子图像的定量分析在临床肿瘤学中的应用

耿建华; 陈英茂

耿建华 , 陈英茂

文章导航 > 国际放射医学核医学杂志 > 2005, 29 > 1: (6-9)

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正电子图像的定量分析在临床肿瘤学中的应用

耿建华¹,
陈英茂²

1. 100021 北京, 中国医学科学院肿瘤医院核医学科;
2. 100853 北京, 解放军总医院核医学科
中图分类号: R817.4;R730.44

Clinical applications of quantitative parameters of positron images in oncology

GENG Jian-hua¹,
CHEN Ying-mao²

1. Department of Nuclear Medicine, Cancer Hospital, Chinese Academy of Medical Scienses, Beijing 100021, China;
2. Department of Nuclear Medicine, General Hospital of PLA, Beijing 100853, China
CLC number: R817.4;R730.44

摘要: 临床肿瘤学中常用的正电子图像定量分析指标为标准化摄取值(SUV)及病灶/本底计数比(L/B)。L/B主要用于双探头符合系统;而SUV在专用型PET中普遍应用,主要用于肿瘤的良恶性鉴别、分期、疗效评估及预测生存期及治愈期。本文对L/B及SUV在肿瘤诊疗中的应用进行了分析,并对SUV应用中的注意事项进行了总结。
- 正电子图像 /
- 标准化摄取值 /
- 靶/本底计数比 /
- 肿瘤学
Abstract: The standardized uptake value (SUV) and the ratio of lesion's counts to background counts (L/B) are usually used in clinical oncology. L/B is mostly used for dual-head coincidence detection system. SUV is widely used for dedicated PET in differentiating the benign and the malignant, tumor staging, evalu-ating therapy response and predicting patient survival and disease-free interval. And some factors which should be paid attention to in clinical application are presented.
- positron image /
- standardized uptake value /
- ratio of lesion's counts to background counts /
- oncology
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Weber WA, Neverve J, Sklarek J, et al. Imaging of lung cancer with fluorine-18 fluoradeoxyglucose:comparison of a dual-head gamma camera in coincidence mode with a full-ring positron emission tomography system[J]. Eur J Nucl Med, 1999, 26(4):388-395.
[2]	Tatsumi M, Yutani K, Watanabe Y, et al. Feasibility of fluorodeoxyglucose dual-head gamma camera coincidence imaging in the evaluation of lung cancer:comparison with FDG PET[J]. J Nucl Med, 1999, 40(4):566-573.
[3]	Weber W, Young C, Abdel-Dayem HM, et al. Assessment of pulmonary lesions with ¹⁸F-fluorodeoxyglucose positron imaging using coincidence mode gamma cameras[J]. J Nucl Med, 1999, 40(4):574-578.
[4]	Yutani K, Tatsumi M, Eiichi S, et al. comparison of dual-head coincidence gamma camera FDG imaging with FDG PET in detecting of breast cancer and axillary lymph node metastasis[J]. J Nucl Med,1999, 40(6):1003-1008.
[5]	Aoki J, Watanabe H, Shinozaki T, et al. FDG-PET in differential diagnosis and grading of chondrosarcomas[J]. J Comput Assist Tomogr, 1999, 23(4):603-608.
[6]	Benard F, Sterman D, Smith RJ, et al. Prognostic value of FDG PET imaging in malignant pleural mesothelioma[J]. J Nucl Med, 1999, 40(8):1241-1245.
[7]	Eary JF, O'Sullivan F, Powitan Y, et al. Sarcoma tumor FDG uptake measured by PET and patient outcome:a retrospective analysis[J].EurJ Nucl Med, 2002, 29(9):1149-1154.
[8]	Vansteenkiste JF, Stroobants SG, Dupont PJ, et al. Prognostic importance of the standardized uptake value on ¹⁸F-Fluoro-2-dexoy-glucose-positron emission tomography scan in non-small-cell lung cancer:. An analysis of 125 cases[J]. J Clin Oncol, 1999, 17(10):3201-3206.
[9]	Chen CH, Muzic RF Jr, Nelson AD, et al. Simultaneous recovery of size and radioactivity concentration of small spheroids with PET data[J]. J Nuel Med, 1999, 40(1):118-130.
[10]	Zimny M, Kaiser H J, Wildberger J, et al. Analysis of FDG uptake with hybrid PET using standardised uptake values[J]. Eur J Nucl Med, 2001, 28(5):586-592.
[11]	Wieder HA, Brucher BL, Zimmermann F, et al. Time course of tumor metabolic activity during chemoradiotherapy of esophageal squamous cell carcinoma and response to treatment[J]. J Clin Oncol,2004, 22(5):900-908.
[12]	Sakarnato H, Nakai Y, Ohashi Y, et al. Monitoring of response to radiotherapy with tluorine-18 deoxyglucose FDG PET of head and neck squamous cell carcinomas[J]. Acta Otolaryngol, 1998,538(suppl):254-260.
[13]	Kitagawa Y, Sadato N, Azuma H, et al. ¹⁸F-FDC. PET to evaluate combined intra-arterial chemotherapy and radiotherapy of head and neck neoplasms[J]. J Nucl Med, 1999, 40(7):1132-1137.
[14]	Kostakoglu L, Goldsmith SJ. PET in assessment of therapy response in patients with carcinoma of the head and neck and of the esgphagus[J]. J Nucl Med, 2004, 45(1):56-68.
[15]	Huang SC. Anatomy of SUV[J]. Nucl Med Biol, 2000, 27(7):643-646.
[16]	Visvikis D, Cheze-LeRest C, Costa DC, et al. Influence of OSEM and segmented attenuation correction in the calculation of standardized uptake values for[¹⁸FDG PET[J]. Eur J Nucl Med, 2001, 28(9):1326-1335.
[17]	黄建敏,付占立,潘莉萍.¹⁸F-FDG代谢显像标准摄取值的影响因素[J].国外医学·放射医学核医学分册,2004,28(1):3-5.
[18]	Ramos CD, Erdi YE, Gonen M, et al. FDG-PET standardized uptake values in normal anatomical structures using iterative reconstruction segmented attenuation correction and filtered back-projection[J].Eur J Nucl Med, 2001, 28(2):155-164.
[19]	耿建华,陈英茂,陈盛祖.¹⁸F-FDG图像糖代谢定量分析中的输入函数及集总常数[J].国外医学·放射医学核医学分册,2003,27(6):263-266.
[20]	Lerman H, Master U, Grisaru D, et al. Normal and abnormal ¹⁸F-FDG endometrlal and ovarian uptake in pre- and postmenopausal vatients:assessment by PET/CT[J]. J Nucl Med, 2004, 45(2):266-271.
[21]	李林法.¹⁸F-FDG分子符合成像非肿瘤性摄取与对策[J].国外医学·放射医学核医学分册,2002,26(5):205-209.
[22]	Beaulieu S, Kinahan P, Tseng J, et al. SUV varies with time after injection in ¹⁸F-FDG PET of breast cancer:characterization and method to adjust for time differences[J]. J Nucl Med, 2003, 44(7):1044-1050.
[23]	Ishii K, Sakamoto S, Hosaka K, et al. Variation in FDG uptakes in different regions in normal human brain as a function of the time (30and 60 min)after injection of FDG[J]. Ann Nucl Med, 2002, 16(4):299-301.

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[2]	黄建敏 , 付占立 , 潘莉萍 . ¹⁸F-FDG代谢显像标准摄取值的影响因素. 国际放射医学核医学杂志, 2004, 28(1): 3-5.
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[7]	赵军 . PET/CT:当前研究和应用新进展. 国际放射医学核医学杂志, 2003, 27(5): 193-197.
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正电子图像的定量分析在临床肿瘤学中的应用

耿建华¹
陈英茂²

1. 100021 北京, 中国医学科学院肿瘤医院核医学科;
2. 100853 北京, 解放军总医院核医学科

收稿日期: 2004-09-14

关键词:

摘要: 临床肿瘤学中常用的正电子图像定量分析指标为标准化摄取值(SUV)及病灶/本底计数比(L/B)。L/B主要用于双探头符合系统;而SUV在专用型PET中普遍应用,主要用于肿瘤的良恶性鉴别、分期、疗效评估及预测生存期及治愈期。本文对L/B及SUV在肿瘤诊疗中的应用进行了分析,并对SUV应用中的注意事项进行了总结。