辐射对骨髓造血微环境影响的研究进展

高颖

辐射对骨髓造血微环境影响的研究进展

高颖

文章导航 > 国际放射医学核医学杂志 > 2000, 24 > 4: (183-185)

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辐射对骨髓造血微环境影响的研究进展

高颖

300020 天津, 中国医学科学院, 中国协和医科大学血液学研究所

作者简介: 高颖(1972-),女,江苏无锡人,中国医学科学院、中国协和医科大学血液学研究所基础部实习研究员,硕士,主要从事造血微环境研究。;

中图分类号: Q691.5

Curent developments in the study of effects of irradiation on bone marrow haematopoietic microenvironment

GAO Ying

Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China
CLC number: Q691.5

摘要: 骨髓造血完全依赖骨髓微环境的支持和调控,早期和近期的观察均提出了辐射对骨髓造血微环境基质细胞的远期影响,并发现在某些实验条件下,辐射后基质细胞的集落刺激能力上升,生长因子(如GM-GSF)和粘附分子(如VCAM-1)表达升高。
- 辐射 /
- 骨髓基质细胞 /
- 生长因子 /
- 粘附分子
Abstract: Hemotopoiesis completely depends on the regulation of the microenvironment. It has been indicated in the early and recent study the long-term effects of radiation on bone marrow microenvironment. It has been found in some experiments that after radiation the colony stimulating activity, the expression of growth factor (GMCSF) and adhesion molecule(V CAM-1) of the stroma cells was elevated.
- irradiation /
- bone marrow stroma cell /
- growth factor /
- adhesion molecule
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