<sup>123</sup>I-epidepride:多巴胺D<sub>2</sub>受体显像剂

¹²³I-epidepride:多巴胺D₂受体显像剂

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¹²³I-epidepride:多巴胺D₂受体显像剂

摘要: ¹²³I-epidepride是一种较好的多巴胺D₂受体SPCET显像剂,其亲和力高(K_d=24pmol/L),亲脂性相对较低(lgK_w=2.05),适于纹状体和纹状体外造影,在垂体腺瘤显像中有较高的临床应用价值,并可预测一些垂体腺瘤对多巴胺治疗的反应。
- ¹²³I-epidepride /
- 多巴胺D₂受体 /
- 单光子发射计算机断层显像
Abstract: ¹²³I-epidepride, ¹²³I-(s)-N-[(1-ethyl-2-pyrrolidinyl) methyl]-5-iodo-2, 3-dimethoxybenzamide,is a potent imaging agent for SPECT of dopamine D₂ receptor. With high affinity (K_d=24pmol/L) and relatively low lipophilicity (lgK_w=2.05), it's suitable for imaging in striated and extrastriated. In addition, it has high value in imaging of dopamine D₂ receptors in pituitary adenoma, and it can serve as a predictor for response to dopamine agonist treatment.
- ¹²³I-epidepride /
- dopamine D₂ receptor /
- single photon emission computed tomography
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