放射增敏剂研究概况

李莉

放射增敏剂研究概况

李莉

文章导航 > 国际放射医学核医学杂志 > 2001, 25 > 2: (87-90)

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放射增敏剂研究概况

李莉

300192 天津, 中国医学科学院中国协和医科大学放射医学研究所

作者简介: 李莉(1975-),女,湖北十堰人,中国医学科学院中国协和医科大学放射医学研究所博士研究生,主要从事肿瘤乏氧的研究。;

中图分类号: R730.5

Survey of research on radiation-sensitizing agents

LI Li

Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
CLC number: R730.5

摘要: 肿瘤乏氧是导致放疗失败的一个重要原因,放射增敏剂由于能提高乏氧细胞对射线的敏感性而受到广泛重视。目前,放射增敏剂的研究包括传统硝基咪唑类化合物、乏氧细胞毒性物、一氧化氮供体、血红蛋白别构效应物和金属卟啉等,它们通过不同作用机制改善组织氧合状态或选择性杀死乏氧细胞,从而提高细胞对射线敏感性。由于肿瘤微环境极其复杂,尽管已合成了大量不同类型的化合物,但尚未发现真正能适用于临床的药物。
- 放射增敏剂 /
- 乏氧细胞毒性物 /
- 一氧化氮供体 /
- 血红蛋白别构效应物 /
- 金属卟啉
Abstract: Hypoxia in solid tumors is a major problem for radiotherapy, so great interest has been given to the development of radiosensitizers which can enhance tissue response to radiation. Nowadays, research on radiosensitizers includes conventional nitroimidazoles, hypoxic cytotoxins, nitric oxide donor agents, allosteric effectors of haemoglobin, metalloporphyrins and so on. They can either increase oxygen delivery to the tumor or selectively kill the hypoxic cells. Though many compounds of different types have been synthesized, none of them can be used clinically because of the complexity of tumor microenviroment.
- radiation-sensitizing agents /
- hypoxic cytotoxins /
- nitric oxide donor agents /
- allosteric effectors of haemoglobin /
- metalloporphyrins
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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[3]	解荷芝 , 金一尊 . 一氧化氮释放剂的放射增敏作用. 国际放射医学核医学杂志, 1997, 21(4): 192-193.
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放射增敏剂研究概况

李莉

作者简介:李莉(1975-),女,湖北十堰人,中国医学科学院中国协和医科大学放射医学研究所博士研究生,主要从事肿瘤乏氧的研究。

300192 天津, 中国医学科学院中国协和医科大学放射医学研究所

收稿日期: 2000-12-14

关键词:

摘要: 肿瘤乏氧是导致放疗失败的一个重要原因,放射增敏剂由于能提高乏氧细胞对射线的敏感性而受到广泛重视。目前,放射增敏剂的研究包括传统硝基咪唑类化合物、乏氧细胞毒性物、一氧化氮供体、血红蛋白别构效应物和金属卟啉等,它们通过不同作用机制改善组织氧合状态或选择性杀死乏氧细胞,从而提高细胞对射线敏感性。由于肿瘤微环境极其复杂,尽管已合成了大量不同类型的化合物,但尚未发现真正能适用于临床的药物。