促血小板生成素与辐射损伤

张军权 张浩

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促血小板生成素与辐射损伤

    作者简介: 张军权(1967-),男,天津蓟县人,北京放射医学研究所博士研究生,主要研究放射病的治疗。;张浩(1968-),男,天津市人,北京放射医学研究所助理研究员,博士,主要研究方向:基因治疗。;
  • 中图分类号: R818.4

Thrombopoietin and radiation injury

  • CLC number: R818.4

  • 摘要: TPO(促血小板生成素)是巨核系造血的主要刺激因子,近年的研究表明,TPO与造血干细胞之间存在密切联系。TPO可促进辐射损伤后的造血重建,有可能解决急性放射病中血小板恢复滞后的问题。TPO在造血干细胞移植、血小板采集与分离等领域也有广阔的应用前景。
  • [1] Eaton DL, de Sauvage FJ. Thrombopoietin:the primary regulator of megakaryocytopoiesis and thrombopoiesis[J]. Exp Hematol, 1997, 25(1):1-7.
    [2] Kaushansky K. Thrombopoietin and the hematopoietic stem cell[J]. Blood, 1998, 92(1):1-3.
    [3] Alexander WS. Thrombopoietin and the c-Mpl receptor:insights from gene targeting[J]. Int J Biochem, Cell Biol, 1999, (10):1027-1035.
    [4] Mouthon M A, Vandamme M, Gourmelon P, et al. Preferential liver irradiation enhancies hematopoiesis through a thrombopoietin-independent mechanism[J]. Radiat Res, 1999, 152(4):390-397.
    [5] Cohen-Solal K, Villeval JL, Titeux M, et al. Constitutive expression of mpl ligand transcripts during thrombocytopenia or thrombocytosis[J]. Blood, 1996, 88(7):2578-2584.
    [6] Kaushansky K, Lin N, Chossmann A, et al. Thrombopoietin expands erythroid, granulocyte macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice[J]. Exp Hematol, 1996, 24(2):265-269.
    [7] Hokom M M, Lacey D, Kinstler OB, et al. Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice[J]. Blood, 1995, 86(12):4486-4492.
    [8] Farese AM, Hunt P, Grab LB, et al. Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation induced marrow aplasia[J]. J Clin Invest, 1996, 97(9):2145-2151.
    [9] Fibbe WE, Heemskerk DP, Laterveer L, et al. Accelerated reconstitution of platlets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice[J]. Blood, 1995, 86(9):3308-3313.
    [10] Neelis KJ, Dubbelman YD, Qingliang L, et al. Simultaneous administration of T PO and G-CSF after cytoreductive treatment of rhesus monkeys prevents thrombocytopenia, accelerates platlet and red cell reconstitution, alleviates neutropenia, and promotes the recovery of immature bone marrow cells[J]. Exp Hematol, 1997, 25(10):1084-1093.
    [11] Neelis K J, Dubbelman YD, Wognum AW, et al. Lack of efficacy of thrombopoietin and granulocytecolony-stimulating factor after high dose total-body irradiation and autologous stem cell or bone marrow transplantation in rhesus monkeys[J]. Exp Hematol, 1997, 25(10):1094-1103.
    [12] Shibuya K, Akahori H, Takahashi K, et al. Multilineage hematopoietic recovery by a single injection of pegylated recombinant megakaryocyte growth and development factor in myelosuppressed mice[J]. Blood, 1998, 91(1):37-45.
    [13] Neelis KJ, Visser TP, Dimjati W, et al. A single dose of thrombopoietin shortly after myelosuppressive total body irradiation prevents pancytopenia in mice by promoting short-term multilineage spleen-repopulating cells at the transient expense of bone marrow-repopulating cells[J]. Blood, 1998, 92(5):1586-1597.
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  • 收稿日期:  2000-05-15

促血小板生成素与辐射损伤

    作者简介:张军权(1967-),男,天津蓟县人,北京放射医学研究所博士研究生,主要研究放射病的治疗。;张浩(1968-),男,天津市人,北京放射医学研究所助理研究员,博士,主要研究方向:基因治疗。
  • 100850 北京, 北京放射医学研究所

摘要: TPO(促血小板生成素)是巨核系造血的主要刺激因子,近年的研究表明,TPO与造血干细胞之间存在密切联系。TPO可促进辐射损伤后的造血重建,有可能解决急性放射病中血小板恢复滞后的问题。TPO在造血干细胞移植、血小板采集与分离等领域也有广阔的应用前景。

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