18F-氟脱氧葡萄糖的脑肿瘤PET

黄喆敏 左传涛 管一晖

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18F-氟脱氧葡萄糖的脑肿瘤PET

    通讯作者: 管一晖, guanyihui@hotmail.com
  • 中图分类号: R814.42;R817.4

Non 18F-fluorodeoxyglucose PET imaging of brain tumors

    Corresponding author: GUAN Yi-hui, guanyihui@hotmail.com
  • CLC number: R814.42;R817.4

  • 摘要: 由于大脑皮质的葡萄糖摄取相对较高,常规18F-氟脱氧葡萄糖(18F-FDG)PET对于脑肿瘤,特别是低度恶性脑肿瘤的显像有较大的局限性.近年来,各种特异性更高的放射性示踪剂如11C-甲硫氨酸(11C-MET),11C-胆碱(11C-choline),18F-氟脱氧胸苷(18F-FLT)等越来越多地应用于脑肿瘤显像.非18F-FDG的放射性示踪剂在脑肿瘤的显像中均具有脑本底摄取低、肿瘤影像对比度好、对低级别胶质瘤敏感性较高的优点,在脑肿瘤的诊断、鉴别诊断、放疗计划的制定及疗效监测等方面比18F-FDG有着明显的优势.
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    [5] 张锦明田嘉禾 . 11C标记的放射性药物在PET-CT肿瘤诊断上的应用. 国际放射医学核医学杂志, 2005, 29(5): 232-237.
    [6] 徐志英李善春11C-甲硫氨酸PET在乳腺癌诊疗中的价值. 国际放射医学核医学杂志, 2008, 32(5): 299-301.
    [7] 蔡莉李彦生 . 氟代脱氧葡萄糖与氨基酸PET在脑肿瘤中的对比研究. 国际放射医学核医学杂志, 2005, 29(1): 10-14.
    [8] 陈跃 . 颅内肿瘤放射治疗后18F-氟代脱氧葡萄糖PET的临床意义. 国际放射医学核医学杂志, 2006, 30(2): 97-99.
    [9] 华逢春11C-METPET在脑肿瘤中的应用. 国际放射医学核医学杂志, 2002, 26(1): 1-4.
    [10] 马妍高硕 . PET在儿童颅内肿瘤中的临床应用. 国际放射医学核医学杂志, 2008, 32(3): 153-158.
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出版历程
  • 收稿日期:  2006-12-26

18F-氟脱氧葡萄糖的脑肿瘤PET

    通讯作者: 管一晖, guanyihui@hotmail.com
  • 200235 上海, 上海复旦大学附属华山医院PET中心

摘要: 由于大脑皮质的葡萄糖摄取相对较高,常规18F-氟脱氧葡萄糖(18F-FDG)PET对于脑肿瘤,特别是低度恶性脑肿瘤的显像有较大的局限性.近年来,各种特异性更高的放射性示踪剂如11C-甲硫氨酸(11C-MET),11C-胆碱(11C-choline),18F-氟脱氧胸苷(18F-FLT)等越来越多地应用于脑肿瘤显像.非18F-FDG的放射性示踪剂在脑肿瘤的显像中均具有脑本底摄取低、肿瘤影像对比度好、对低级别胶质瘤敏感性较高的优点,在脑肿瘤的诊断、鉴别诊断、放疗计划的制定及疗效监测等方面比18F-FDG有着明显的优势.

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