X射线修复交叉互补基因功能的研究进展

王芹

X射线修复交叉互补基因功能的研究进展

王芹

文章导航 > 国际放射医学核医学杂志 > 2005, 29 > 3: (132-136)

引用本文:

Citation:

X射线修复交叉互补基因功能的研究进展

王芹

300192 天津, 中国医学科学院协和医科大学放射医学研究所
中图分类号: Q345.7

The recent advance in identification and functions of X ray repair cross complementing genes

WANG Qin

Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
CLC number: Q345.7

摘要: 对X射线修复交叉互补(XRCC)基因功能的研究极大地促进了对哺乳动物DNA损伤修复过程和遗传不稳定性致癌机制的理解。通过观察XRCC基因突变体的表型,可以对其功能进行鉴定。目前已鉴定的这一基因家族的多数成员均参与几种重要的DNA修复途径,包括碱基切除修复、同源重组修复和非同源末端重接。XRCC基因的鉴定及其在DNA损伤修复和维持遗传稳定性过程中发挥重要的作用。
- X射线修复交叉互补基因 /
- 碱基切除修复 /
- 同源重组修复 /
- 非同源末端重接
Abstract: The researches on functions of X ray repair cross complementing(XRCC) genes had promoted the understanding of DNA damage repair processes and the mechanism of cancer induced by genetic instability. The functions of XRCC genes could be identified by studying their mutant phenotypes. Most members of the XRCC genes family participated in several DNA repair pathways, including base excision repair, homologous recombination repair and non-homologous end joining. The identification of XRCC genes and their functions took important parts in DNA damage repairs and genetic stability processes.
- X ray repair cross complementing genes /
- base excision repair /
- homologous recombination repair /
- non-homologous end joining
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Schreiber V, Ame JC, Dolle P, et al. Poly(ADP-ribose) polymerase-2(PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1[J]. J Biol Chem, 2002, 277(25):23028-23036.
[2]	Thompson LH, West MG. XRCC1 keeps DNA from getting stranded[J]. Mutat Res, 2000, 459(1):1-18.
[3]	Godthelp BC, Wiegant WW, van Duijn-Goedhart A, et al. Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability[J]. Nucleic Acids Res,2002, 30(10):2172-2182.
[4]	LiuY, MassonJY, ShahR, etal. RAD51CisrequiredforHolliday junction processing in mammalian cells[J]. Science, 2004, 303(5655):243-246.
[5]	Woods T, Wang W, Convery E, et al. A single amino acid substitution in DNA-PKcs explains the novel phenotype of the CHO mutant,XR-C2[J]. Nucleic Acids Res, 2002, 30(23):5120-5128.
[6]	Sado K, Ayusawa D, Enomoto A, et al. Identification of a mutated DNA ligase Ⅳ gene in the X-ray-hypersensitive mutant SX10 of mouse FM3A cells[J]. J Biol Chem, 2001, 276(13):9742-9748.
[7]	Riballo E, Critchlow SE, Teo SH, et al. Identification of a defect in DNA ligase Ⅳ in a radiosensitive leukaemia patient[J]. Curr Biol,1999, 9(13):699-702.
[8]	O'Driscoll M, Cerosaletti KM, Girard PM, et al. DNA ligase Ⅳmutations identified in patients exhibiting developnental delay and immunodeficiency[J]. Mol Cell, 2001, 8(6):1175-1185.
[9]	Tuteja R, Tuteja N. Ku autoantigen:a multifunctional DNA-binding protein[J]. Crit Rev Biochem Mol Biol, 2000, 35(1):1-33.
[10]	Chan DW, Chen BP, Prithivirajsingh S, et al. Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks[J]. Genes Dev, 2002, 16(18):2333-2338.
[11]	Ferguson DO, Sekiguchi JM, Chang S, et al. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations[J]. Proc Natl Acad Sci USA,2000, 97(12):6630-6633.
[12]	Deans B, Griffin CS, O'Regan P, et al. Homologous recombination deficiency leads to profound genetic instability in cells derived from Xrcc2-knockout mice[J]. Cancer Res, 2003, 63(23):8181-8187.
[13]	Venkitaraman AR. Chromosome stability, DNA recombination and the BRCA2 tumnour suppressor[J]. Curr Opin Cell Biol, 2001, 13(3):338-343.
[14]	Goode EL, Ulrich CM, Potter JD. Polymorphisms in DNA repair genes and associations with cancer risk[J]. Cancer Epidemiol Biomarkers Prev, 2002,11(12):1513-1530.

[1]	杜利清 , 刘强 , 王彦 , 徐畅 , 曹嘉 , 付岳 , 陈凤华 , 樊飞跃 . Ku70对同源重组修复蛋白Rad51的调节作用. 国际放射医学核医学杂志, 2013, 37(5): 272-274. doi: 10.3760/cma.j.issn.1673-4114.2013.05.005
[2]	王芹 , 刘强 , 孙元明 , 樊赛军 , 樊飞跃 . X射线交叉互补修复基因多态性与肿瘤. 国际放射医学核医学杂志, 2013, 37(6): 370-373. doi: 10.3760/cma.j.issn.1673-4114.2013.06.011
[3]	刘民培 , 张永令 , 高凤鸣 . 从耐辐射微球菌DNA中5,6二羟二氢胸腺嘧啶的切除修复. 国际放射医学核医学杂志, 1982, 6(1): 56-56.
[4]	官宜彬 , 夏寿萱 . 辐射所致的DNA碱基损伤和它的修复——在癌变中的意义及血清学检测方法. 国际放射医学核医学杂志, 1987, 11(2): 73-77.
[5]	郭润志 , 徐家筱 , 唐谨 . 镓扫描结合胸部X线检查判断肺癌的可切除性. 国际放射医学核医学杂志, 1979, 3(3): 208-208.
[6]	张睿 , 张卿西 . 鼠肝脏部分切除后经X线照射的再生. 国际放射医学核医学杂志, 1988, 12(1): 34-34,66.
[7]	曹恩华 . 基因水平的DNA修复研究近况. 国际放射医学核医学杂志, 1993, 17(4): 145-149.
[8]	田生礼 , 蔡露 , 高风呜 . 由X射线引起精子和成熟卵母细胞损伤的小鼠受精卵的修复能力. 国际放射医学核医学杂志, 1990, 14(5): 212-212.
[9]	沈淑敏 . DNA损伤修复. 国际放射医学核医学杂志, 1980, 4(1): 19-21.
[10]	孙炜 , 朱高红 , 卫江亮 , 胡建伟 . 老年患者胆囊切除术围手术期血浆内皮素和降钙素基因相关肽水平分析. 国际放射医学核医学杂志, 2011, 35(2): 104-107. doi: 10.3760/cma.j.issn.1673-4114.2011.02.009

点击查看大图

计量

文章访问数: 2004
HTML全文浏览量: 945
PDF下载量: 3

X射线修复交叉互补基因功能的研究进展

王芹

300192 天津, 中国医学科学院协和医科大学放射医学研究所

收稿日期: 2005-03-30

关键词:

摘要: 对X射线修复交叉互补(XRCC)基因功能的研究极大地促进了对哺乳动物DNA损伤修复过程和遗传不稳定性致癌机制的理解。通过观察XRCC基因突变体的表型,可以对其功能进行鉴定。目前已鉴定的这一基因家族的多数成员均参与几种重要的DNA修复途径,包括碱基切除修复、同源重组修复和非同源末端重接。XRCC基因的鉴定及其在DNA损伤修复和维持遗传稳定性过程中发挥重要的作用。