摘要:
摘要:目的 探讨动态观察早孕药物流产孕妇血清β-人绒毛膜促性腺激素(β-HCG)、雌二醇(E)及孕酮(P)水平变化的临床价值。方法 对55例停经时间35~39 d、证实早孕而要求终止妊娠的孕妇给予米非司酮配伍米索前列醇,使用化学发光免疫分析法对服药前后外周血β-HCG、E及P水平动态监测,进行回顾性分析。结果 所有早孕妇女孕囊排出后7 d时β-HCG、E、P水平均明显降低(tβ-HCG=4.845,tE=7.655,tP=11.390,P<0.05)。孕囊排出后7 d时E和P水平迅速下降到卵泡期水平,14 d较7 d时雌二醇明显上升(tE=9.089,P<0.05);21 d较14 d时P有明显升高(tP=2.910,P<0.05)。结论 化学发光免疫分析法测定血清β-HCG、E和P水平可以间接评价米非司酮配伍米索前列醇药物流产的疗效,并预测药流后阴道出血时间是否延长,从而早期判断预后,为尽早给予临床干预提供依据。
Abstract:
Objective To observe the value of the changes of serum β-human chorionic gonadotropin(β-HCG),estradiol(E),progesterone(P)Levels of early pregnancy after drug-induced abortion dynamically.Methods Assessing 55 women proved pregnant by urine or blood HCG retrospecticly,who had terminated their pregnancy by mifepristonr and misoprostol.Meanwhile the serum levels of β-HCG,E,P were monitored dynamically.Results Among the 55 patients,the levels of β-HCG,E and P had significant decreased(tβ-HCG=4.845,tE=7.655,tP=11.390,P<0.01).On the 7th day,the levels of E and P decreased to the level of follicle phase.The level of E on the 14th day was higher than that of 7th day(tE=9.089,P<0.05); the level of P was higher than that of 14th day(tP=2.910,P<0.05).Conclusion Detecting the serum hormone's levels after drug-induced abortion by chemiluminescent immunoassay,we can assess indirectly the value of administration of mifepristone and misoprostol,predict the prolonged vaginal bleeding after drug-induced abortion,and the outcome of the treatment,which determine wether need another curestage.
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