Abstract: The incidence of thyroid cancer is increases year by year. Traditional treatment for radioiodine refractory differentiated thyroid cancer is limited.Targeted therapy is a popular new treatment method in recent years, and has achieved positive results in the treatment of thyroid carcinoma. This article reviews the accurate targeting therapy strategy of radioiodine refractory differentiated thyroid carcinoma, drug targeting therapy, peptide receptor radionuclide targeting therapy, local precise therapy and immunotherapy.