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全身131I显像用于诊断分化型甲状腺癌(differ-entiated thyroid cancer,DTC)患者有无转移及复发,对DTC分期、疗效评价和预测预后有重要价值。全身131I显像具有很高的灵敏度,但特异度不高,如无法区分非甲状腺组织来源的假阳性病变以及病变不能精确定位等。 DTC全身131I显像有两种,一种为服用111~185 MBq 131I后48~72 h采集的诊断性全身显像(diagnostic whole body scan,Dx-WBS),另一种为常规大剂量131I治疗后2~10 d进行的治疗性全身显像(posttreatment whole body scan,Rx-WBS),后者所用的131I剂量远高于前者,可发现较多病灶和新病灶,是对DTC进行再分期和确定131I治疗适应证的基础[1]。随着SPECT/CT 逐渐普及,其能提供更丰富的解剖信息和定位信息,有效提高诊断的特异度[2]。本文就DTC患者全身131I显像中腹盆部假阳性摄取研究进行综述。
分化型甲状腺癌腹盆部131I显像假阳性分析
Analysis of differentiated thyroid cancer false-positive uptake in abdominal cavity and pelvic cavity on radioiodine whole-body scan
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摘要: 全身131I显像时,除了甲状腺组织、分化型甲状腺癌(DTC)转移及复发灶显影外,非甲状腺组织来源的假阳性病变也常不同程度地摄取131I而显影。探讨DTC患者腹盆部非甲状腺组织来源的假阳性病变摄取131I的不同原因,分析其可能存在的病变信息,可以给临床诊疗提供必要的帮助,笔者就有关腹盆部131I显像假阳性研究进行综述。Abstract: When it comes to 131I radioiodine whole-body scan, normal thyroid tissue and differentiated thyroid cancer(DTC) can uptake radioiodine, so does the non-thyroid tissue to some extent. The understanding of the possible explanations for the abnormal radioiodine uptake in the abdominal cavity and pelvic cavity tissue on I-131 radioiodine whole-body scan is of great importance to clinical diagnosis. The relevant reports about this field are reviewed.
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