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耐辐射奇球菌(Deinococcus radiodurans,DR)因其强大的辐射抗性而闻名于世,它拥有极强的电离辐射抗性,且对紫外线、干燥、氧化剂等造成的DNA损伤有强大的修复作用,因此被公认为是研究辐射抗性的模式生物[1]。就目前的研究成果来看,DR的辐射抗性机制主要包括:①特殊的生理特性与功能;②高效的DNA修复能力;③强大的抗氧化能力[2]。
耐辐射奇球菌辐射抗性机制及其双组份系统的研究
The mechanism of resistance and two-component system in Deinococcus radiodurans
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摘要: 耐辐射奇球菌拥有极强的辐射抗性能力并能在多种极端环境下存活。其特有的一些辐射抗性基因在其抗性机制中发挥重要作用。双组份系统是广泛存在于细菌中的一种信号转导系统,它能协助细菌应对外界环境的变化,对维持各种生命活动至关重要。双组份系统作为一种应激响应机制在耐辐射奇球菌中有重要作用。笔者就耐辐射奇球菌的抗性机制及其双组份系统的研究进行综述。Abstract: Deinococcus radiodurans(DR) has strong resistance to radiation and comprises a series of mechanisms that allow it to survive under various extreme conditions. Some of the genes existing in DR particularly contribute to its robust viability. Two-component system(TCS) is a signal transduction system that widely exists in bacteria. This system can assist the bacteria in coping with the change in external environment and is vital for various life activities. Given that TCS plays an important role in resistance mechanism as a stress response system, this article reviewed the resistant mechanism and the TCS in DR.
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Key words:
- Deinococcus /
- Radiation tolerance /
- Two-component system
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