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放疗是肿瘤治疗的重要手段之一,而肿瘤细胞辐射敏感性降低和辐射抵抗是肿瘤放疗效果不显著甚至失败的重要原因。因此,阐明肿瘤细胞辐射抵抗的分子信号途径是提高肿瘤细胞辐射敏感性的重要基础。信号转导和转录激活因子(signal transducer and activator of transcription,STAT)是一类既具信号转导功能又有转录活化功能的细胞质转录因子[1]。大量研究表明,STAT3在细胞增殖、存活、凋亡、血管生成、免疫和细胞迁移等过程中均发挥重要的调节作用。同时,在大多数肿瘤细胞中STAT3的活性较高[2],预示着STAT3在肿瘤的发生、发展中扮演着重要角色,可能成为肿瘤增敏治疗的潜在分子靶点,其与肿瘤辐射敏感性的关系也越来越引起人们的重视。笔者对近年来STAT3与肿瘤辐射敏感性的关系的研究进行概述。
STAT3与辐射敏感相关性的研究进展
Research progresses of correlation between STAT3 and radiosensitivity
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摘要: 放疗是肿瘤治疗的主要方法之一, 但肿瘤的辐射抵抗是影响放疗疗效的一个重要原因。信号转导和转录激活因子3(STAT3)是STAT家族的重要成员, 与肿瘤的发生、发展紧密相关。电离辐射可以对STAT3的表达水平产生影响, 同时STAT3的表达水平也可反作用于细胞, 通过对肿瘤细胞DNA损伤、自噬、凋亡、增殖、血管生成、迁移、侵袭、免疫抑制等的调节影响其辐射敏感性, 这预示着以STAT3为突破口的辐射敏感性研究将会为肿瘤临床治疗提供新策略。Abstract: Radiotherapy is one of the main methods in cancer treatment, but the tumor radioresistance is a main point influencing the efficiency of radiotherapy. STAT3 is an important member of the STAT family and it is closely correlated with tumor incidence and development.The expression of STAT3 can be altered by ionizing radiation and hence it could affect radiosensitivity of tumour cells by regulating DNA damage, autophagy, apoptosis, proliferation, angiogenesis, migration, invasion and immune suppression. Accordingly, the deep understanding the role of STAT3 in radiation sensitivity may provide a new strategy for clinical cancer therapy.
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Key words:
- STAT3 transcription factor /
- Neoplasms /
- Radiotherapy /
- Radiation tolerance
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