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电离辐射导致动脉粥样硬化(atherosclerosis,AS)于1959年被首次报道[1]。AS发病原因十分复杂,其确切病因尚未完全阐明,大量流行病学调查显示,众多遗传或环境因素与AS的发生存在明显相关性,但是尚不能确定具有直接的因果关系,习惯上称这些因素为AS的危险因素。与高血压、高血脂、吸烟和糖尿病一样,电离辐射也是诱发AS的独立危险因素之一,其亦可与其他因素一起共同作用于动脉血管,加速AS的形成。辐射所致的AS被认为是辐射导致心血管疾病致死的主要原因,尤其是照射10年之后,其发病率大大提高[2-3]。
电离辐射诱发动脉粥样硬化的研究进展
Research progress of radiation induced atherosclerosis
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摘要: 电离辐射可以诱发动脉粥样硬化(AS)。随着接受辐射治疗后长期存活肿瘤患者的增多, 受照射人群心血管疾病的发病率也明显增加。辐射诱发AS涉及炎症性改变、氧化应激及基因不稳定性等过程, 电离辐射旁效应也可能与AS的发病存在一定相关性。笔者对近年来辐射诱发AS的相关研究进行了概述, 试图为深入研究辐射诱导AS的形成机制、为放射治疗预防药物靶点的选择提供一定的思路。Abstract: Ionizing radiation can induce atherosclerosis(AS). With increasing survival of patients after radiation therapy, the incidence of cardiovascular disease has increased significantly in the irradiated population. It is important to know the pathogenesis of ionizing radiation-induced AS. Amount of studies showed that the occurrence of AS is related to radiation-induced inflammatory, oxidative stress and genomic instability. Radiation induced bystander effect might also plays an effective role in AS induction. We hereby reviewed recent reports about radiation-induced AS and try to increase the knowledge of targeting therapy.
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Key words:
- Radiation, Ionizing /
- Atherosclerosis /
- Bystander effect
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图 1 辐射诱导的血管损伤的生物学性状和分子水平的改变[22]
Figure 1. Biological and molecular alterations in radiation-induced vascular effects
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