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甲状腺功能亢进症(简称甲亢)以Graves甲亢最多见,是一种以甲状腺激素分泌异常增多为主要特征的器官特异性自身免疫性疾病,其发病是遗传和环境因素共同作用的结果[1]。Graves甲亢病程长,随病程进展临床表现呈多样化,常常也会伴发各种并发症如肝功能损害(简称肝损害)(转氨酶异常、黄疸指数增高)、血液系统异常(白细胞减少、粒细胞减少)、甲状腺相关眼病、甲亢性心脏病、甲亢合并肌无力和周期性麻痹等,严重者会危及生命。随着131I应用的普及,甲亢伴合并症选择131I治疗也越来越受到关注,本文就甲亢合并肝损害或血细胞减少这两种并发症的131I治疗的优势与风险作简要综述。
131I治疗Graves甲亢合并肝功能损害或血细胞减少的优势与风险
The advantage and risk of 131I treatment in hyperthyroidism combined with liver injury or blood cell reduction
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摘要: 目前甲状腺功能亢进症(甲亢)治疗主要有3种方法:抗甲状腺药物治疗、131I治疗和手术治疗。随着131I在甲亢治疗中的安全性得到肯定, 临床上选择131I治疗的病例不断增加, 特别是甲亢伴合并症时选择131I治疗较多且备受关注。笔者结合国内外最新相关报道及临床实践, 就131I治疗甲亢合并肝功能损害或血细胞减少两种合并症的优势与风险作简要综述。Abstract: At present, anti-thyroid drugs, radioactive iodine(131I) and surgical therapy were considered as the three major methods for hyperthyroidism therapy. With the acceptance of the safety of 131I therapy in hyperthyroidism, more and more patients become to choose it as their therapeutic method, especially the patients with liver injury or blood cell reduction complications. This paper summaries the advantages and risks of 131I therapy in this two special hyperthyroidism patients groups according to the recent paper and clinical practice.
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Key words:
- Graves disease /
- Hyperthyroidism /
- Brachytherapy /
- Liver diseases /
- Blood cell reduction
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