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肾脏是人体血流量最大的器官,临床上许多肾脏疾病都会导致肾脏血流灌注的改变,评价肾脏血流灌注状态对肾脏疾病的诊断、了解肾功能等方面具有重要临床意义[1]。肾动态显像测定肾血流是广为应用的非创伤性方法,然而对其结果的评价大多采用目视阅片法,该方法的不足之处是主观性强、易受照片质量以及显像剂“弹丸”式注射质量的影响。采用核素血管造影定量化分析指标——Hilson血流灌注方法分析“弹丸”式注射后肾时间- 放射性强度曲线,计算肾脏灌注指数(perfusion index,PI),采用量化指标[2],有利于克服上述缺点,现报道如下。
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疾病组与对照组的性别差异无统计学意义(X2= 1.228,P > 0.05);年龄差异无统计学意义(t=1.742,P > 0.05)。
正常对照组测定肾脏40个,疾病组共测定肾脏145个。对照组和疾病组各分组的PI、GFR测定结果见表 1。慢性肾功能不全、肾动脉狭窄、肾病综合征、肾积水、输尿管结石及肾结石的PI值均高于正常对照组,差异具有统计学意义。
组别 例数 PI GFR/[ml/(min·1.73m2)] 左肾 右肾 右肾 右肾 慢性肾功能不全 28 459.28±68.15*
(t=17.21)476.67±38.99*
(t=18.14)23.46±14.51 21.56±15.46 肾动脉狭窄 7 436.14±61.88*
(t=15.54)420.85±66.39*
(t=14.21)26.45±15.12 24.12±12.17 肾病综合征 5 379.40±111.00*
(t=12.41)372.20±99.52*
(t=13.89)27.85±26.12 26.12±27.11 肾积水 24 333.75±140.94*
(t=7.18)321.08±132.43*
(t=8.19)30.12±26.17 32.15±22.14 输尿管结石及肾结石 16 267.75±149.93*
(t=6.74)283.37±142.63*
(t=7.24)31.07±21.14 32.45±19.17 正常对照组 20 147.20±41.14 155.25±41.73 44.59±18.14 43.25±18.21 表中,*表示与对照组比较,P < 0.01;PI:灌注指数;GFR:肾小球滤过率。 表 1 患者按疾病种类分组各组的PI、GFR测定结果
Table 1. The perfusion indexes and glomerular filtration rates of the patients were grouped according to the type of disease
疾病组按照肾脏功能GFR值分组各组的PI及GFR测定结果见表 2,各组PI值均高于正常对照组,差异具有统计学意义。
组别 例数 PI GFR/[ml/(min·1.73m2)] 左肾 右肾 右肾 右肾 轻度肾功能受损组 24 328.62±41.21*(t=10.21) 335.14±39.85*(t=11.14) 37.22±13.51 35.11±14.91 中度肾功能受损组 33 412.27±53.81*(t=6.87) 427.86±61.12*(t=7.12) 23.33±14.15 21.52±16.81 重度肾功能受损组 23 466.81±110.64*(t=13.97) 471.64±112.96*(t=14.87) 10.27±9.45 9.82±8.45 正常对照组 20 147.20±41.14 155.25±41.73 44.59±18.14 43.25±18.21 表中,*表示与对照组比较,P < 0.01;PI:灌注指数;GFR:肾小球滤过率。 表 2 肾功能不同程度受损组各组的PI、GFR测定结果
Table 2. The perfusion indexes and glomerular filtration rates of the patients were grouped according to renal function
这185个肾脏的PI与GFR的相关性分析呈负相关(r=-0.741,P < 0.05),PI=542.61-7.94×GFR。
Hilson血流灌注指数在肾脏疾病中的应用
Application of Hilson perfusion index in kidney disease
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摘要:
目的 探讨Hilson血流灌注指数(PI)在肾病患者中的临床应用价值。 方法 20例健康者为对照组, 80例肾脏疾病患者为疾病组, 测定两组的Hilson血流PI及肾小球滤过率(GFR)。 结果 对照组左肾PI为147.2±41.14, 右肾PI为155.25±41.73, 疾病组的慢性肾功能不全、肾动脉狭窄、肾病综合征、肾积水、输尿管结石及肾结石患者的左、右肾PI分别为459.28±68.15、476.67±38.99;436.14±61.88、420.85±66.39;379.40±111.00、372.20±99.52;333.75±140.94, 321.08±132.43;267.75±149.93、283.37±142.63。轻、中、重度肾功能受损患者的左、右肾PI分别为328.62±41.21、335.14±39.85;412.27±53.81、427.86±61.12;466.81±110.64、471.64±112.96, 均高于正常对照组, PI结果与GFR呈负相关, 相关系数r=-0.741。 结论 Hilson血流PI有较高的临床应用价值。 -
关键词:
- 肾疾病 /
- 肾小球滤过率 /
- 灌注指数 /
- Hilson血流灌注
Abstract:Objective To investigate the clinical application value of Hilson perfusion index(PI) in patients with kidney disease. Methods The PI value and glomerular filtration rate(GFR) of 20 normal people and 80 patients with kidney disease were measured. Results The normal PI values for the left and right kidneys were 147.2±41.14 and 155.25±41.73, respectively, whereas the PI values for chronic renal failure, stenosis of renal artery, nephrotic syndrome, hydronephrosis, and renal calculus for the left and right kidneys were 459.28±68.15, 476.67±38.99; 436.14±61.88, 420.85±66.39; 379.40±111.00, 372.20±99.52; 333.75±140.94, 321.08±132.43; and 267.75±149.93, 283.37±142.63, respectively. Moreover, the PI values for mild, moderate, and severe renal impairment of the left and right kidneys were 328.62±41.21, 335.14±39.85; 412.27±53.81, 427.86±61.12; and 466.81±110.64, 471.64±112.96, respectively, which were higher than those in the normal control group. The PI results were negatively correlated with GFR, and the correlation coefficient(r) was 0.741. Conclusion Hilson perfusion index exhibited high clinical value. -
Key words:
- Kidney diseases /
- Glomerular filtration rate /
- Perfusion index /
- Hilson perfusion index
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表 1 患者按疾病种类分组各组的PI、GFR测定结果
Table 1. The perfusion indexes and glomerular filtration rates of the patients were grouped according to the type of disease
组别 例数 PI GFR/[ml/(min·1.73m2)] 左肾 右肾 右肾 右肾 慢性肾功能不全 28 459.28±68.15*
(t=17.21)476.67±38.99*
(t=18.14)23.46±14.51 21.56±15.46 肾动脉狭窄 7 436.14±61.88*
(t=15.54)420.85±66.39*
(t=14.21)26.45±15.12 24.12±12.17 肾病综合征 5 379.40±111.00*
(t=12.41)372.20±99.52*
(t=13.89)27.85±26.12 26.12±27.11 肾积水 24 333.75±140.94*
(t=7.18)321.08±132.43*
(t=8.19)30.12±26.17 32.15±22.14 输尿管结石及肾结石 16 267.75±149.93*
(t=6.74)283.37±142.63*
(t=7.24)31.07±21.14 32.45±19.17 正常对照组 20 147.20±41.14 155.25±41.73 44.59±18.14 43.25±18.21 表中,*表示与对照组比较,P < 0.01;PI:灌注指数;GFR:肾小球滤过率。 表 2 肾功能不同程度受损组各组的PI、GFR测定结果
Table 2. The perfusion indexes and glomerular filtration rates of the patients were grouped according to renal function
组别 例数 PI GFR/[ml/(min·1.73m2)] 左肾 右肾 右肾 右肾 轻度肾功能受损组 24 328.62±41.21*(t=10.21) 335.14±39.85*(t=11.14) 37.22±13.51 35.11±14.91 中度肾功能受损组 33 412.27±53.81*(t=6.87) 427.86±61.12*(t=7.12) 23.33±14.15 21.52±16.81 重度肾功能受损组 23 466.81±110.64*(t=13.97) 471.64±112.96*(t=14.87) 10.27±9.45 9.82±8.45 正常对照组 20 147.20±41.14 155.25±41.73 44.59±18.14 43.25±18.21 表中,*表示与对照组比较,P < 0.01;PI:灌注指数;GFR:肾小球滤过率。 -
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