-
应用99Tcm标记的骨显像剂进行放射性核素骨显像已有40余年的历史[1],经历了直线扫描机、γ照相机、SPECT、SPECT/CT、PET/CT等显像技术时代,实现了放射性核素全身和局部骨显像、平面和断层骨显像、动态和多时相显像、融合显像等多种显像方式。
SPECT/CT骨断层显像及在恶性肿瘤骨转移诊断中的临床价值
The clinical value of SPECT/CT bone tomography in the diagnosis of malignant tumor metastasis
-
摘要: 骨骼是恶性肿瘤常见的转移部位之一,骨转移常常与疾病的预后紧密相关,因而放射性核素骨显像在肿瘤骨转移的诊断中具有举足轻重的作用。平面骨显像凭借着其反映骨骼病变的高灵敏度广泛应用于临床,且具有检查费用较低、可反映骨代谢血流及不受金属置入物影响等优点。较之平面骨显像,SPECT/CT骨断层显像可以更好地定位病变,对病变的检出率更高且诊断的特异性更强。该文对SPECT/CT骨断层显像及其在诊断恶性肿瘤骨转移中的临床价值进行综述。
-
关键词:
- 肿瘤转移 /
- 体层摄影术,发射型计算机,单光子 /
- 体层摄影术,X线计算机 /
- 骨骼
Abstract: Bone is one of the most favorite sites of malignant tumor metastasis, and bone metastasis usually correlates with the prognosis of disease, which leads to the important place of bone scintigraphy in the diagnosis of bone metastasis. Bone scan is widely used in clinical work for its high sensitivity as well as its low cost, revealing bone metabolism and blood flow, and no limitation of metal implantation. Compared with plain bone scan, SPECT/CT bone tomography shows better orientation of lesion, and has higher detection rates and specificity. This article reviews the diagnostic value of malignant tumor bone metastasis. -
[1] Subramanian G, McAfee JG, Blare RJ, et al. Technethium-99m-methylene diphosphonate—a superior agent for skeletal imaging: Comparison with other technethium complexes[J]. J Nucl Med, 1975, 16(8): 744-755. [2] 匡安仁, 李林.核医学[M].北京:高等教育出版社, 2008: 112-119.
[3] Kagohashi K, Satoh H, Ishikawa H, et al. Bone metastasis as the first manifestation of lung cancer[J]. Int J Clin Pract, 2003, 57(3): 184-186. [4] Mohsen B, Werner L, Lgnac F, et al. Prostate cancer: role of SPECT and PET in imaging bone metastases[J]. Semin Nucl Med, 2009, 39(6): 396-407. [5] Simona BH, Ora I. Breast cancer: role of SPECT and PET in imaging bone metastases[J]. Semin Nucl Med, 2009, 39(6): 408-415. [6] Mettler FA, Bhargavan M, Thomadsn, BR, et al. Nuclear medicine exposure in the United States. 2005~2007: Preliminary results[J]. Semin Nucl Med, 2008, 38(3): 384-391. [7] EI-Maghraby TA, Moustafa HM, Pauwels EK. Nuclear medicine methods for evaluation of skeletal infection among other diagnostic modalities[J]. Q J Nucl Med Mol Imaging, 2006, 50(3): 167-192. [8] Brandon D, Alazraki A, Halkar RK, et al. The role of single-photon emission computed tomography and SPECT/computed tomography in oncologic imaging[J]. Semin Oncol, 2011, 38(1): 87-108. doi: 10.1053/j.seminoncol.2010.11.003 [9] 汪勇, 米岚, 余大富, 等. SPECT/CT对脊柱病变鉴别诊断的价值[J].中华核医学与分子影像杂志, 2011, 31(4): 223-226. doi: 10.3760/cma.j.issn.0253-9780.2011.04.003
[10] Savelli G, Maffoli L Maccauro, M, et al. Bone scintigraphy and the added value of SPECT(single photon emission tomography)in detecting skeletal lesions[J]. Q J Nucl Med, 2001, 45(1): 27-37. [11] Helyar V, Mohan HK, Barwick T, et al. The added valule of multislice SPECT/CT in patients with equivocal bony metastasis from carcinoma of the prostate[J]. Eur J Nucl Med Mol Imaging, 2010, 37(4): 706-713. doi: 10.1007/s00259-009-1334-3 [12] 王新华, 赵艳萍, 陆海健, 等. SPECT/CT显像诊断转移性骨肿瘤的临床意义[J].中华核医学与分子影像杂志, 2010, 30(2): 106-109. doi: 10.3760/cma.j.issn.0253-9780.2010.02.010
[13] 张一秋, 石洪成, 顾宇参, 等. SPECT/CT骨显像对肺癌骨转移诊断的增益价值[J].中华核医学与分子影像杂志, 2011, 31(4): 219-222. doi: 10.3760/cma.j.issn.0253-9780.2011.04.002
计量
- 文章访问数: 2448
- HTML全文浏览量: 1617
- PDF下载量: 8