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分化型甲状腺癌(differentiated thyroid carcinoma,DTC)是最常见的甲状腺恶性肿瘤,其中大部分是甲状腺乳头状癌(papillary thyroid cancer,PTC),约占85%[1]。甲状腺球蛋白(thyroglobulin,Tg)水平在PTC术后131I治疗随访中有重要的价值,是判断甲状腺癌复发或转移的重要指标之一[2-3],近年来备受关注。但对Tg与PTC颈部淋巴结转移的关系却少有报道,本研究分析了45例PTC患者术后刺激状态Tg水平与颈部淋巴结转移的关系,现报道如下。
甲状腺乳头状癌术后刺激状态Tg与颈部淋巴结转移关系的研究
The correlation between the stimulated thyroglobulin level after surgery in papillary thyroid carci-noma and cervical lymph node metastasis
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摘要:
目的 探讨甲状腺乳头状癌(PTC)患者术后刺激状态甲状腺球蛋白(Tg)与颈部淋巴结转移的关系。 方法 45例PTC患者行甲状腺全切或近全切并行颈部淋巴结清扫术,根据是否存在淋巴结转移分为L1和L0 2组,检测术后刺激状态Tg水平,采用统计学软件对数据进行t检验及相关性分析。 结果 2组患者的年龄(t=-0.675,P > 0.05)、性别(χ2=1.20,P > 0.05)差异无统计学意义,术后刺激状态Tg水平差异有统计学意义(t=4.167,P < 0.01)。L1组术后刺激状态Tg水平与颈部淋巴结转移水平呈正相关(r=0.676,P < 0.01)。 结论 PTC患者术后刺激状态Tg水平与颈部淋巴结转移关系密切,是评价PTC术后131I治疗疗效及判断预后的重要指标。 Abstract:Objective To discuss the correlation between the stimulated thyroglobulin (Tg) level after surgery in papillary thyroid carcinoma (PTC) and cervical lymph node metastasis. Methods Total thyroidectomy or subtotal thyroidectomy and radical cervical lymphadenectomy have been performed in 45 cases with PTC. All patients have been divided into two groups (L1 group and L0 group) according to whether lymph node metastasis exists. The stimulated Tg level after surgery were mesured and analyzed by t test with statistical software. Results There was no significant difference between the two groups in age (t=-0.675, P > 0.05) and gender(χ2=1.20, P > 0.05), but significant difference could be found in stimulated Tg level after surgery between the two groups(t=4.167, P < 0.01). There was positive correlation between the stimulatied Tg level after surgery and cervical lymph node metastasis in L1 group(r=0.676, P < 0.01). Conclusion The stimulated Tg level after surgery is closely correlated to cervical lymph node metastasis in patients with PTC, which can be used as an assessment of the effect of the postsurgical 131I therapy and prognosis. -
Key words:
- Thyroid neoplasms /
- Carcinoma /
- papillary /
- Thyroglobulin /
- Lymph nodes
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