-
自1971年Folkman[1]首次提出肿瘤血管生成的假说以来,大量研究表明肿瘤血管生成与肿瘤的生长、恶变、转移以及患者的预后有密切的关系[2]。能够成功地在体监测肿瘤血管生成及抗血管治疗的成像方法成为目前研究的热点。传统的成像手段能对肿瘤血管的一些参数,如血流速度、微血管密度以及肿瘤的新陈代谢等进行直接或间接的评估,但由于缺乏特异性,难以定量研究。近年来,分子影像学技术在肿瘤血管生成的可视化及定量研究中取得了一定的进展。本文就各种分子影像学技术在肿瘤血管生成研究中的现状做一综述。
肿瘤血管生成的分子影像学研究进展
Advances of molecular imaging in tumor angiogenesis
-
摘要: 肿瘤血管生成与肿瘤的生长、恶变、转移以及患者的预后有着密切的关系,因此,肿瘤的抗血管生成治疗引起了人们的极大兴趣。分子影像学应用高亲和力的分子探针与靶分子特异性结合的原理,可在活体细胞和分子水平上特征性地显示及测量生物机体的生化过程。近年来,分子影像学技术在肿瘤血管生成的可视化及定量研究中取得了一定的进展,有望成为肿瘤早期诊断与靶向治疗评价的重要手段。该文综述了肿瘤血管生成的分子影像学技术的最新进展。Abstract: Tumor angiogenesis has a close relationship with tumor growth, progression, metastasis and the prognosis of tumor patients. Therefore, tumor anti-angiogenic treatment arouses great public interest. Molecular imaging can characteristically display and measure the biochemical process of organisms at cellular and molecular level in vivo, which is based on the specific binding of molecular probe with high affinity and target molecules. In recent years, molecular imaging has a certain progress on visual and quantitative research of tumor angiogenesis and it is expected to become an important technique in the efficacy evaluation and prognostic assessment. This article summarizes the new advances of molecular imaging technology in tumor angiogenesis.
-
[1] Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med, 1971, 285(21): 1182-1186. [2] Mazeron R, Bourhis J, Deutsch E. Angiogenesis: all a radiation oncologist should know. Cancer Radiother, 2008, 12(1): 50-60. [3] 张国鹏, 兰晓莉, 何勇, 等. 99Tcm-亚锡葡庚糖酸钠结合GGC序列监测基因治疗的实验研究.中华核医学杂志, 2011, 31(2): 128-133.
[4] Wang P, Zhen H, Zhang J, et al. Survivin promotes glioma angiogenesis through vascular endothelial growth factor and basic fibroblast growth factor in vitro and in vivo. Mol Carcinog, 2011[2012-01-10]. http://onlinelibrary.wiley.com/doi/10.1002/mc.20829/abstract;jsessionid=719EB7C1790AF3BC30D13D2BF55D8814.d03t02. [published online ahead of print July 14, 2011]. [5] 赵新明, 戴萌, 刘亚丽, 等. 99Tcm-survivin mRNA反义肽核酸制备及荷瘤裸鼠基因显像研究.中华核医学杂志, 2011, 31(5): 339-343.
[6] Li JL, Harris AL. Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications. Front Biosci, 2009, 14: 3094-3110. [7] 杨明福, 李前伟.肿瘤血管内皮生长因子受体核素显像研究现状.国际放射医学核医学杂志, 2010, 34(1): 19-22.
[8] Blankenberg FG, Backer MV, Levashova Z, et al. In vivo tumor angiogenesis imaging with site-specific labeled 99Tcm-HYNIC-VEGF. Eur J Nucl Med Mol Imaging, 2006, 33(7): 841-848. [9] 黄定德, 李前伟, 刘广元, 等. 99Tcm标记多肽VEGF125-136及其生物学分布.第三军医大学学报, 2007, 29(17): 1660-1662.
[10] Backer MV, Levashova Z, Patel V, et al. Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes. Nat Med, 2007, 13(4): 504-509. [11] von Wallbrunn A, Höltke C, Zühlsdorf M, et al. In vivo imaging of integrin ανβ3 expression using fluorescence-mediated tomography. Eur J Nucl Med Mol Imaging, 2007, 34(5): 745-754. [12] Liu S. Radiolaboled muhimeric cyclic RGD peptides as integrin ανβ3 targeted radiotracers for tumor imaging. Mol Pharm, 2006, 3(5): 472-487. [13] 余子璘, 贾兵, 刘昭飞, 等. 99Tcm标记RGD环肽四聚体在神经胶质瘤裸鼠模型中的显像研究.中华核医学杂志, 2009, 29(2): 103-108.
[14] 李玲, 胡漫, 于金明, 等.非小细胞肺癌99Tcm-HL91 SPECT乏氧显像中HL91摄取程度与乏氧诱导因子1α和血管内皮生长因子表达的关系.中华肿瘤杂志, 2009, 31(9): 669-673.
[15] Bourgeois M, Rajerison H, Guerard F, et al. Contribution of[64Cu]-ATSM PET in molecular imaging of tumour hypoxia compared to classical[18F]-MISO—a selected review. Nucl Med Rev Cent East Eur, 2011, 14(2): 90-95. [16] Grönroos T, Bentzen L, Marjamaki P, et al. Comparison of the biodistribution of two hypoxia markers[18F]FETNIM and[18F] FMISO in an experimental mammary carcinoma. Eur J Nucl Med Mol Imaging, 2004, 31(4): 513-520. [17] Wang JH, Min PQ, Wang PJ, et al. Dynamic CT evaluation of tumor vascularity in renal cell carcinoma. AJR Am J Roentgenol, 2006, 186(5): 1423-1430. [18] Sipkins DA, Cheresh DA, Kazemi MR, et al. Detection of tumor angiogenesis in vivo by ανβ3-targeted magnetic resonance imaging. Nat Med, 1998, 4(5): 623-626. [19] Gossmann A, Helbich TH, Kuriyama N, et al. Dynamic contrast-enhanced magnetic resonance imaging as a surrogate marker of tumor response to anti-angiogenic therapy in a xenograft model of glioblastoma multiforme. J Magn Reson Imaging, 2002, 15(3):233-240. [20] Palmowski M, Huppert J, Ladewig G, et al. Molecular profiling of angiogenesis with targeted ultrasound imaging: early assessment of antiangiogenic therapy effects. Mol Cancer Ther, 2008, 7(1): 101-109. [21] Peng L, Liu R, Andrei M, et al. In vivo optical imaging of human lymphoma xenograft using a library-derived peptidomimetic against α4β1 integrin. Mol Cancer Ther, 2008, 7(2): 432-437.
计量
- 文章访问数: 1973
- HTML全文浏览量: 1039
- PDF下载量: 2