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心血管疾病(cardiovascular disease,CVD) 是世界范围内导致患者残疾和过早病死的主要原因之一,据世界卫生组织报道,2004年,全球约有1.7亿人死于CVD,约占所有病死人数的29%,而其中因冠心病致死者约为7200万人,约占所有CVD死亡人数的42%[1],因此,能够在早期及时诊断冠心病、无创和准确地进行心脏不良事件的风险评估并及时干预成为亟待解决的临床问题。目前在此领域的研究进展颇多,以下就心血管风险评估、心肌灌注显像(myocardial perfusion imaging,MPI)与冠状动脉钙化积分(coronary artery calcification score,CACS)在心脏风险中的地位以及两者之间的相互关系作一综述。
心肌灌注显像与冠状动脉钙化积分对冠心病风险评估的研究现状及相互关系
The progress of interrelationship between myocardial perfusion imaging and coronary artery calcium score in cardiac risk assessment
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摘要: 冠心病是严重威胁人类健康的常见病和多发病。早期诊断冠心病,无创、准确地进行心脏不良事件的风险评估并及时干预,是亟待解决的临床问题。风险评估模型对于心脏风险评估的有效性虽已被众多临床试验所证实,但仍有局限性。心肌灌注显像及冠状动脉钙化积分以及两者结合,为冠心病诊断及心脏风险的评估提供了新的思路。Abstract: Coronary heart disease(CHD) is a common and frequently occurring disease which seriously threaten the health of human beings. So diagnosing CHD early and assessing the cardiac risk accurately and non-invasively that is a clinical problem which is urgent need for solving. Although the effectiveness of risk assessment algorithms have been proved by lots of clinical trials, but still has some limitations. The combination of myocardial perfusion imaging and coronary artery calcium score is promising in CHD diagnosis and cardiac risk assessment.
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