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99Tc-亚甲基二膦酸盐(99Tc-methylenediphosphonate, 99Tc-MDP)注射液也称“云克”, 作为治疗药物能明显抑制巨噬细胞产生白细胞介素1(interleukin-1, IL-1), 具有抗炎、抗风湿作用; 能抑制前列腺素的合成, 具有明显镇痛作用。其中, MDP通过螯合金属离子可降低胶原酶对关节滑膜组织的破坏作用, 99Tc可以清除人体内的自由基, 保护超氧化物歧化酶(superoxide dismutase, SOD), 调节人体自身免疫。药代动力学实验表明, 99Tc-MDP对骨关节部位有明显的靶向性, 故用药量少, 安全高效。
99Tc-亚甲基二膦酸盐的临床应用研究进展
Progress of 99Tc-methylenediphosphonate in clinical applications
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摘要: 99Tc-亚甲基二膦酸盐(99Tc-MDP)可以抑制炎性反应,发挥抗炎、抗风湿作用;能抑制前列腺素的合成,具有明显镇痛作用。此外,99Tc-MDP还可通过调节人体自身免疫及调节骨代谢而发挥作用。临床上99Tc-MDP主治类风湿性关节炎、强直性脊柱炎、甲亢伴浸润性突眼等自身免疫性疾病,对癌转移痛、股骨头坏死及骨质疏松也有较好疗效。
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关键词:
- 关节炎, 类风湿 /
- 脊柱炎, 强制性 /
- Graves眼病 /
- 99Tc-亚甲基二膦酸盐
Abstract: The main ingredient of 99Tc-methylenediphosphonate(99Tc-MDP) is chelates which formed by the technetium 99Tc after stannous reduction and methylenediphosphonate.Studies have shown that 99Tc-MDP can inhibit the inflammatory response, play anti-inflammatory, anti-rheumatic effect, it also have significant analgesic effect by inhibit prostaglandin synthesis.In addition, 99Tc-MDP also can regulate the body's own immune and bone metabolism to treat the corresponding diseases.Treating rheumatoid arthritis, ankylosing spondylitis, Graves'ophthalmopathy and other autoimmune diseases.Italso has a good effect on pain which is caused by cancer, femoral head necrosis and osteoporosis.Review progress of 99Tc-MDP in clinical applications. -
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