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目前,辐射损伤的处理措施主要依据欧洲已经建立的比较完善的辐射损伤鉴别分类方案和辐射损伤治疗方案,这两个方案要求,应在辐射损伤48 h内,根据患者的临床性状确定治疗手段[1-2]。生物标志物作为机体接触辐射后出现的一种改变,是指能反映机体与辐射相互作用所引起的生理、生化、免疫和遗传等多方面分子水平改变的物质。通过对生物标志物的自动化检测,能够快速地判断受辐射人群的数量以及评估辐射损伤的程度。以往,仅仅通过患者的临床症状制定辐射事故的救治方案,生物标志物的出现为救治方案的进一步完善提供了新的鉴别诊断依据,尤其对那些辐射事故时间不确定以及辐射损伤超过48 h的患者更具有诊断意义。蛋白标志物作为生物标志物中最为重要的一种,为辐射损伤的诊断、治疗提供了重要价值。
蛋白标志物在辐射损伤中的应用
The applications of protein biomarkers in radiation injury
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摘要: 机体暴露于电离辐射下,一系列分子表达活性将发生变化,特异性改变的蛋白质可作为标志物用于辐射损伤的鉴别分类、治疗防控以及动态观察。该文综述了目前已经确定的或具有潜在功能的数种辐射损伤蛋白标志物的应用价值,介绍了多种蛋白标志物综合分析用于辐射损伤的诊断和治疗的目前研究进展。Abstract: When people are exposed to ionising radiation, a series of molecules changing rapidly followed. Protein biomarkers of radiation injury are critical for triage, treatment, and follow-up of patients. This article reviews the application value of the definitive protein biomarkers with potential function, and introduces the progress in latest research of the multiparametric protein biomarkers analysis for diagnosis and therapy of radiation injury.
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Key words:
- Proteins /
- Biological markers /
- Radiation injury
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