DNA损伤修复及细胞周期检控点激活的研究进展

程晋 邹仲敏

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DNA损伤修复及细胞周期检控点激活的研究进展

  • 基金项目:

    国家自然科学基金(30828007)

The activation of DNA damage repair and cell cycle checking point

  • 摘要: 新近的研究结果使人们对DNA损伤诱导的细胞和分子事件,特别是与DNA损伤反应和损伤修复相关蛋白的激活以及在DNA损伤部位的募集,有了更深入的认识;对细胞周期检控点的激活以及随后的细胞周期调控有了进一步的理解
  • [1] Mohammad DH,Yaffe MB.14-3-3 proteins,FHA domains and BRCT domains in the DNA damage response.DNA Repair(Amst),2009,8(9):1009-1017.
    [2] Lavin MF.ATM and the Mrell complex combin to recognize and sighal DNA double-strand breaks.Oncogene,2007,26(55):7749-7758.
    [3] Lou Z,Chen J.Mammalian DNA damage response pathway,Adv Exp Med Biol,2005,570:425-455.
    [4] Gatei M,Zhou BB,Hobson K,et al.Ataxia telangiectasia mutated(ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brcal at distinct and overlapping sites.In vivo assessment using phospho-specific antibodies.J Biol Chem,2001,276(20):17276-17280.
    [5] van Attikum H,Gasser SM.Crosstalk between histone modifications during the DNA damage response.Trends Cell Biol,2009,19(5):207-217.
    [6] Jackson SP.The DNA-damage response:new molecular insights and new approaches to cancer therapy.Biochem Soc Trans,2009,37(Pt 3):483-494.
    [7] Stucki M,Clapperton JA,Mohammad D,et al.MDCl directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.Cell,2005,123(7):1213-1226.
    [8] Lou Z,Minter-Dykhouse K,Franco S,et al.MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.Mol Cell,2006,21(2):187-200.
    [9] Melander F,Bekker-Jensen S,Falck J,et al.Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin.J Cell Biol,2008,181(2):213-226.
    [10] Yan Y,Black CP,Cao PT,et al.Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1.Cancer Res,2008,68(13):5113-5121.
    [11] Kaufmann WK.Cell cycle checkpoints and DNA repair preserve the stability of the human genome.Cancer Metastasis Rev,1995,14(1):31-41.
    [12] Canman C E.Checkpoint mediators:relaying signals from DNA strand breaks.Curr Biol,2003,13(12):R488-R490
    [13] Stracker TH,Usui T,Petrini JH.Taking the time to make important decisions:the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response.DNA Repair(Amst),2009,8(9):1047-1054.
    [14] Lee JS,Collins KM,Brown AL,et al.hCdsl-mediated phosphorylation of BRCA1 regulates the DNA damage response.Nature,2000,404(6774):201-204.
    [15] Kurosu T,Takahashi Y,Fukuda T,et al.p38 MAP kinase plays a role in G2 checkpoint activation and inhibits apoptosis of human B cell lymphoma cells treated with etoposide.Apoptosis,2005,10(5):1111-1120,
    [16] Kiyokawa H,Ray D.In vivo roles of CDC25 phosphatases:biological insight into the anti-cancer therapeutic targets.Anticancer Agents Med Chem,2008,8(8):832-836.
    [17] Boutros R,Dozier C,Ducommun B.The when and wheres of CDC25 phosphatases.Curr Opin Cell Biol,2006,18(2):185-191.
    [18] Hosing AS,Kundu ST,Dalal SN.14-3-3 Gamma is required to enforce both the incomplete S phase and G2 DNA damage checkpoints.Cell Cycle,2008,7(20):3171-3179.
    [19] Wang XQ,Zhu YQ,Lui KS,et al.Aberrant Polo-like kinase 1-Cdc25A pathway in metastatic hepatocellular carcinoma.Clin Cancer Res,2008,14(21):6813-6820.
    [20] Lobjois V,Jullien D,Bouché JP,et al.The polo-like kinase 1 regulates CDC25B-dependent mitosis entry.Biochim Biophys Acta,2009,1793(3):462-468.
    [21] Jin J,Ang XL,Ye X,et al.Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase.J Biol Chem,2008,283(28):19322-19328.
    [22] Demidova AR,Aau MY,Zhuang L,et al.Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control.J Biol Chem,2009,284(7):4132-4139.
    [23] Uchida S,Yoshioka Kizu R,et al.Stress-activated mitogen-activated protein kinases c-Jun NH2-terminal kinase and p38 target Cdc25B for degradation.Cancer Res,2009,69(16):6438-6444.
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  • 收稿日期:  2009-05-25

DNA损伤修复及细胞周期检控点激活的研究进展

  • 第三军医大学军事预防医学院防化医学教研室, 重庆, 400038
基金项目:  国家自然科学基金(30828007)

摘要: 新近的研究结果使人们对DNA损伤诱导的细胞和分子事件,特别是与DNA损伤反应和损伤修复相关蛋白的激活以及在DNA损伤部位的募集,有了更深入的认识;对细胞周期检控点的激活以及随后的细胞周期调控有了进一步的理解

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