Abstract: Objective To evaluate ⁹⁹Tc^m-diethylenetriamine-pentaacetic acid(⁹⁹Tc^m-DTPA) renal dynamic imaging in judgment of the renal function inpatients with diabetes mellitus(DM) so as to provide reference for clinical treatment and prognosis predicting. Methods Ninety patients with DM were divided into four groups according to the values of urinary albumin excretion rate(UAER).①Group DM,:UAER<20μg·min^-1, 25 cases.②Gruop DM₂:UAER 20-200μg·min^-1, 24 cases.③Group DM;UAER>200μg·min^-1, 23 cases.④a renal function failure group(DM₄), 18 cases. Fourty healthy people were chosen as normal control(NC) group.⁹⁹Tc^m-DTPA radionuclide renal dynamic imaging of glcmerular filtration rate(GFR) was performed and the levels of serum creatinine(SCr), blood urea nitrogen(BUN) and blood β₂-microglobulin(β₂-MG) were measured in the five groups. Results GFR were significantly increased in group DM₁ than those in NC(t=12.5, P<0.01).In group DM₂ GFR was not different from NC. The half activity time(T_1/2) of the renogram was significantly prolonged. The 20 min retention rate(C₂₀) of the renogram increased compared with NC. In group DM₃ and DM₄, GFR was remarkably decreased. The peak time(TP) of the renogram delayed. T_1/2 distinctly prolonged and C₂₀ increased,comparing with NC(r=-0.497,P<0.05). Conclusion Radionuclide renal dynamic imaging is helpful for the evaluation of renal damage in early stage of diabetic nephropathy(DN),judge the injury of the renal function and provide reference for clinical t treatment and follow-up.