口腔癌放射治疗的优化研究
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摘要: 口腔癌是一种常见的黏膜上皮性肿瘤,发病率约占全身恶性肿瘤的3.5%。口腔癌中,鳞状细胞癌占90%以上,2005年WHO在头颈肿瘤病理学和遗传学分类中将口腔鳞状细胞癌定义为"一种具有不同程度分化的侵袭性肿瘤,倾向于早期、广泛的淋巴结转移,主要发生于40~70岁的烟酒嗜好者"[1]。
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[1] Barnes L, Eveson JW, Reichart P, et al. Pathology and genetics of head and neck tumours. Lyon:IARC WHO Classifieation of Tumours Press, 2005:168-175. [2] Garzino-Demo P, Dell' Acqua Clinicopathological parameters and outcome of 245 patients operated for oral squamous cell carcinoma. J Craniomaxillofac Surg, 2006, 34(6):344-350. [3] Liao CT, Chang JT, Wang HM, et al. Does adjuvant radiation therapy improve outcomes in Ptl-3N0 oral cavity cancer with tumor-free margins and perineural invasion?. Int J Radiat Oncol Biol Phys, 2008, 71(2):371-376. [4] Chera BS, Amdur R J, Hinerman RW, et al. Definitive radiation therapy for squamous cell carcinoma of the soft palate. Head Neek, 2008, 30(8):1114-1119. [5] Petera J, Dolezel M, Jirousek Z, et al. High dose rate brachytherapy in the treatment of oral cancer-the preliminary one institution experience. Neoplasma, 2006, 53(3):232-236.
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