替莫唑胺联合适形放疗治疗恶性脑胶质瘤的临床观察
The clinical observation of the treatment for malignant gliomas with temozolomide combined with conformal radiotherapy
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摘要: 恶性脑胶质瘤是成年人中常见的原发性脑瘤,占复发脑瘤的35%~45%[1],其标准治疗方案是手术后辅助放疗.三维适形放疗技术较常规放疗有可减少脑组织损伤、提高肿瘤辐射剂量的优势,但总体疗效仍不令人满意,既往放疗中加入治疗脑胶质瘤化疗药物包括卡氮芥、甲基苄肼等,但与单纯放疗相比无显著的生存益处[2].
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[1] 谷铣之,殷蔚伯,等.肿瘤放射治疗学.北京:北京医科大学中国协和医科大学联合出版社,1997:737-738.
[2] 罗素霞,马保根,陈小兵,等.血清肿瘤标志物联合检测在肺癌诊断中的价值.中华检验医学杂志,2005,28(12):1266.
[3] Brandes AA, Ermani M, Basso U, et al. Temozolomide as a secondline systemic regimen in recurrent high-grade glioma:a phase II study. Ann Oncol, 2001, 12(2):255-257. [4] Shaw EG, Bourland D, Marshall MG. Cancer of the central nervous system//Khan FM, Potish RA. Treatment planning in radiation oncology. Pennsylvania:Lippincott Williams and Wilkins, 1998:491-544. [5] van Rijn J, Heimans JJ, van den Berg J, et al. Survival of human glionm cells treated with various combination of temozolomide and X-rays. Int J Radiat Oncol Biol Phys, 2000, 47(3):779-784. [6] Corsa P, Parisi S, Raguso A, et al. Temozolomide and radiotherapy as first-line treatment of high-grade gliomas. Tumori, 2006, 92(4):299-305. [7] Stupp R, Mason WP, van den Bent M J, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med, 2005, 352(10):987-996.
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