Gadd45与基因组稳定性

贾立立; 樊飞跃

doi:10.3760/cma.j.issn.1673-4114.2009.02.013

Gadd45与基因组稳定性

贾立立 , 樊飞跃

文章导航 > 国际放射医学核医学杂志 > 2009, 33 > 2: (105-109)

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Gadd45与基因组稳定性

北京协和医学院, 中国医学科学院放射医学研究所生物学研究室, 天津 300192

Gadd45 and genomic stability

Department of Biology Laboratory, Institute of Radiation Medicine, Chinese Academy of Medical Sciences Peking Union Medical College, Tianjin 300192, China

摘要: Gadd45基因是生长抑制及DNA损伤诱导基因家族中的一员,是电离辐射效应基因之一,在细胞周期调控、DNA损伤修复及细胞凋亡过程中发挥重要作用,这使它成为维持基因组稳定性的重要基因,在肿瘤细胞存活、凋亡信号通路中发挥错综复杂的作用,从而参与肿瘤的发生和发展.
- 基因,Gadd45 /
- 基因组不稳定性 /
- 肿瘤
Abstract: Gadd45 gene is one of growth arrest and DNA damage-inducible(Gadd)family.It's also a gene induced by ionization radiation.It plays an important role in controlling cell cycle,repairing damaged DNA and in cell apoptosis.This makes it work as an improtant gene in mainteining genomic stability.but more importantly it induces cell apoptosis and is a bridge in the cascade process of apoptosis of tumor cell.At the same time,it takes part in tumorigenesis.
- Gene, Gadd45 /
- Genomic instability /
- Neoplasms
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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