25-羟维生素D参考区间的建立及其临床意义
Establishment of 25-OH-vitamin D reference interval by radioimmunoassay and its clinical significance
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摘要: 目的 建立区域人群25-羟维生素D (25-OH-Vit D)的参考区间,并对用于临床评估提出建议.方法 收集204例健康参考个体的样本,用放射免疫法进行检测,对检测结果进行离群点检查、绘制数据分布图,统计分析25-OH-Vit D的检测结果,对参考区间进行验证和建立.结果 建立的25-OH-Vit D参考区间青少年为16.0~39.7 ng/ml,成年人为11.7~40.0 ng/ml.结论 25-OH-Vit D在人体水平因各个地区人群的年龄、性别、生活习惯等的差异而有所不同.国内区域人群维生素D的摄入量可能整体偏低,故临床医生在评估维生素D状态时,应考虑人体所应有的足够量的25-OH-Vit D.Abstract: Objective To establish reference interval of 25-OH-vitamin D(25-OH-Vit D)by radioimmunoassay and provide suggestion for clinical applications.Method Collecting 204 healthy persons specimens,and validating and establishing reference interval of 25-OH-Vit D by treatment of outlying observations,iudgement of data distributions and analysis of teat results.Results The reference interval of 25-OH-Vit D established in our laboratory is 16.0~39.7 ng/ml for adolescents and 11.7~40.0 ng/ml for adults.Conclusions The levels of 25-OH-Vit D in humans depend on their age,sex and life style.Some people's vitamin D intake is not enough.Doctors should pay attention to the sufficient 25-OH-Vit D needed when evaluate vitamin D intake.
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Key words:
- Radioimmunoassay /
- Reference values /
- 25-OH-Vit D
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[1] Wang TJ, Pencina MJ, Booth SL, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation, 2008, 117(4):503-511. [2] Clinical and Laboratory Standards Institute. Defining, establishing, and verifying reference intervals in the clinical laboratory; approved guideline-third edition. CLSI document C28-A3. Wayne, PA:Clinical and Laboratory Standards Institute, 2008. [3] 崔庆华,张云,薛元明,等.健康儿童,青少年血清生长激素的参考值调查.放射免疫学杂志,2000,13(2):73-74.
[4] Zittermann A. Vitamin D in preventative medicine:are we ignoring the evidence?. Br J Nutr, 2003, 89(5):552-572.
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