腺苷负荷脑灌注显像安全性研究

胡鹏程; 顾宇参; 刘文官; 修雁; 朱玮珉; 陈曙光; 石洪成

doi:10.3760/cma.j.issn.1673-4114.2009.02.006

腺苷负荷脑灌注显像安全性研究

胡鹏程 , 顾宇参 , 刘文官 , 修雁 , 朱玮珉 , 陈曙光 , 石洪成

文章导航 > 国际放射医学核医学杂志 > 2009, 33 > 2: (83-85)

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腺苷负荷脑灌注显像安全性研究

复旦大学附属中山医院核医学科, 上海 200032
基金项目:
教育部留学回国人员科研启动基金资助项目

Safety of adenosine in stress cerebral perfusion imaging

Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China

摘要: 目的评价腺苷负荷脑血流灌注显像的安全性.方法以腺苷负荷作为介入手段,按照常规腺苷负荷心肌灌注显像的方式,对80例脑病患者进行隔日法静息和负荷脑血流灌注显像.观察、记录患者在负荷过程前、中、后的主观、客观不良反应.结果 80例患者中没有发现因不良反应而提前终止或延长负荷显像的病例.有46例(58%)出现不同程度轻微不良反应.其主要症状包括头晕20例(25%)、心悸12例(15%)、低血压1例(1%)、气短7例(9%)、发热4例(5%)、出汗3例(4%)、恶心4例(5%)、皮肤潮红6例(8%)、胸部不适19例(24%)、腹部不适6例(8%)、味觉异常3例(4%)、口干1例(1%).只有1例出现ST段轻度压低心电图改变.结论腺苷负荷脑血流灌注显像安全性好,不良反应轻微.
- 腺苷 /
- 脑 /
- 体层摄影术,发射型计算机,单光子 /
- 99m-双半胱乙酯
Abstract: Objective To evaluate the safety of adenosine as pharmacological stress agents in stress cerebral perfusion imaging. Methods Eighty patients under investigation for suspected cerebral vessel disease were recruited. Each had a resting seen and a stress scan on different days. The adenosine stress protocol was as same as the protocol used in adenosine stress myocardial perfusion imaging. Subjective and objective side-effects were investigated during pharmacological stress procedure. Results All patients completed the 6 min infusion protocol without premature termination on safety criteria or due to intolerable symptoms. 46 patients had mild side effects. 20 patients (25%) had dizziness, 12 patients (15%) had palpitation, 1 patient (1%) was hypotensive, 7 patients (9%) had dyspnoea, 4 patients (5%) felt hot, 3 patients (4%) had sweat, 4 patients (5%) had nausea, 6 patients (8%) had flushing, 19 patients (24%) had chest pain, 6 patients (8%) had abdomen pain, 3 patients (4%) had abnormal taste and 1 patient (1%) were thirsty. Transient ST change occurred in only 1 patient. Conclusion Adenosine stress cerebral perfusion imaging is a safe diagnostic method with mild side effects
- Adenosine /
- Brain /
- Tomography, emission-computed, single-photon /
- ^99mTc-ethy cysteinate dimer
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

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腺苷负荷脑灌注显像安全性研究

复旦大学附属中山医院核医学科, 上海 200032

收稿日期: 2008-10-09

基金项目: 教育部留学回国人员科研启动基金资助项目

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摘要: 目的评价腺苷负荷脑血流灌注显像的安全性.方法以腺苷负荷作为介入手段,按照常规腺苷负荷心肌灌注显像的方式,对80例脑病患者进行隔日法静息和负荷脑血流灌注显像.观察、记录患者在负荷过程前、中、后的主观、客观不良反应.结果 80例患者中没有发现因不良反应而提前终止或延长负荷显像的病例.有46例(58%)出现不同程度轻微不良反应.其主要症状包括头晕20例(25%)、心悸12例(15%)、低血压1例(1%)、气短7例(9%)、发热4例(5%)、出汗3例(4%)、恶心4例(5%)、皮肤潮红6例(8%)、胸部不适19例(24%)、腹部不适6例(8%)、味觉异常3例(4%)、口干1例(1%).只有1例出现ST段轻度压低心电图改变.结论腺苷负荷脑血流灌注显像安全性好,不良反应轻微.