癫痫脑内相关受体改变及其PET研究

宁艳丽; 晋建华

doi:10.3760/cma.j.issn.1673-4114.2009.02.001

癫痫脑内相关受体改变及其PET研究

宁艳丽 , 晋建华

文章导航 > 国际放射医学核医学杂志 > 2009, 33 > 2: (65-67)

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癫痫脑内相关受体改变及其PET研究

山西医科大学第一医院核医学科, 太原 030001

Study progress on related receptor changes and PET of epilepsy

Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan 030001, China

摘要: 随着脑受体正电子放射性配体的相继研发,PET技术在癫痫相关受体研究中发挥了独特作用,目前癫痫脑内相关受体研究多集中在γ-氨基丁酸受体、乙酰胆碱受体、谷氨酸受体、多巴胺受体及阿片受体等方面。该文就癫痫脑内相关受体与PET研究进展进行综述,以期为临床提供更多的参考。
- 癫痫 /
- 受体,γ-氨基丁酸 /
- 受体,胆碱能 /
- 受体,谷氨酸 /
- 受体,多巴胺 /
- 正电子发射体层摄影术
Abstract: Along with the research and development of some radioligands, PET had play an important role in the researches on receptor-related, especially for gamma-aminobutyricacid receptor, acetylcholine receptor, glutamic acid receptor, dopamine receptor and opioid receptor, et al. In this review, the advances of researches on the receptor-related changes and PET were summarized, so as to provide references for clinical diagnosis and treatment on epilepsy.
- Epilepsy /
- Receptor, gamma-aminobutyric acid /
- Receptor, eholinergic /
- Receptor, glutamic acid /
- Receptor, dopamine /
- Positron-emission tomography
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Liefaard LC, Ploeger BA, Molthoff CF, et al. Changes in GABAA receptor properties in amygdala kindled animals:In vivo studies using[¹¹C]flumazenil and positron emission tomography. Epilepsia, 2009, 50(1):88-98. Epub 2008 Aug 25.
[2]	Marini C, Harkin LA, Wallace RH, et al. Childhood absence epilepsy and febrile seizures:a family with a GABA (A) receptor mutation. Brain, 2003, 126(pt 1):230-240.
[3]	Fedi M, Berkovic SF, Marini C, et al. A GABAA receptor mutation causing generalized epilepsy reduces benzodiazepine receptor binding. Neuroimage, 2006, 32(3):995-1000.
[4]	Zimmerman G, Njunting M, Ivens S, et al. Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats. Eur J Neurosci, 2008, 27(4):965-975.
[5]	Lipovsek M, Plazas P, Savino J, et al. Properties of mutated murine alphagbeta2 nicotinic receptors linked to partial epilepsy. Neurosci Lett, 2008, 434(2):165-169.
[6]	Mohamed A, Eberl S, Fulham M J, et al. Sequential ¹²³I-iododexetimde scans in temporal lobe epilepsy:comparison with neuroimaging scans (MR imaging and ¹⁸F-FDG PET imaging). Eur J Nucl Med Mol Imaging, 2005, 32(2):180-185.
[7]	Picard F, Bruel D, Servent D, et al. Alteration of the in vivo nicotinic receptor density in ADNFLE patients:a PET study. Brain, 2006, 129(Pt 8):2047-2060.
[8]	Yu M, Tueckmantel W, Wang X, et al. Methoxyphenylethynyl, methoxypyridylethynyl and phenylethynyl derivatives of pyridine:synthesis, radiolabeling and evaluation of new PET ligands for metabotropic glutamate subtype 5 receptors. Nucl Med Biol, 2005, 32(6):631-640.
[9]	Severance AJ, Parsey RV, Kumar JS, et al. In vitro and in vivo evaluation of[¹¹C]MPEPy as a potential PET ligand for mGlu5 receptors. Nucl Med Biol, 2006, 33(8):1021-1027.
[10]	Bankstahl JP, Hoffmann K, Bethmann K, et al. Glutamate is critically involved in seizure-induced overexpression of Pglycoprotein in the brain. Neuropharmacology, 2008, 54(6):1006-1016.
[11]	Surmeier DJ, Ding J, Day M, et al. D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons. Trends Neurosci, 2007, 30(5):228-235.
[12]	Fedi M, Berkovic SF, Scheffer IE, et al. Reduced striatal D1 receptor binding in autosomal dominant nocturnal frontal lobe epilepsy. Neurology, 2008, 71(11):795-798.
[13]	Frost JJ. Receptor localization and quantification with PET. Radiology, 1988, 169(1):273-274.
[14]	Hammers A, Asselin MC, Hinz R, et al. Upregulation of opioid receptor binding following spontaneous epileptic seizures. Brain, 2007, 130(Pt 4):1009-1016.

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