镁离子对放射性脑损伤的脑保护作用

杨美玉; 王利利; 涂彧

doi:10.3760/cma.j.issn.1673-4114,2010.06.012

镁离子对放射性脑损伤的脑保护作用

杨美玉 , 王利利 , 涂彧

文章导航 > 国际放射医学核医学杂志 > 2010, 34 > 6: (363-366)

引用本文:

Citation:

镁离子对放射性脑损伤的脑保护作用

1. 苏州大学医学部放射医学与公共卫生学院, 215123;
2. 苏州大学附属第一医院放疗科, 215123

Brain protection by magnesium ion against radioaction brain injury

Academy of Radiation Medicine and Public Health, Medical College of Soochow University, Suzhou 215123, China

摘要: 放射性腩损伤是脑部肿瘤放射治疗的严重并发症之一,近几年对Mg²⁺的研究证明了其在脑损伤中的保护作用,是目前综合性评价前景较好的神经保护剂。该文综述了放射性脑损伤后脑组织中的Mg²⁺变化情况及产生原因,并从减轻炎性反应、减轻脑水肿,抑制脂质过氧化、抗细胞凋亡,改善神经功能等方面分析了Mg²⁺对放射性脑损伤的保护机制。
- 脑损伤 /
- 硫酸镁 /
- 辐射防护
Abstract: Radiation brain injury is a serious complication among the radiotherapy of brain tumors.It is demonstrated that the protective action of magnesium ion in the brain injury from some experimental studies recent years, which is the prospective neuroprotective agents overall merits. This article is summarized the causes and the variance of magnesium ion in the brain tissue afterwards the radioactive brain injury,additionally the defense mechanism of magnesium ion from the aspects of inflammation reduction, encephaledema alleviation, anti-apoptosis and improcement of nerve function.
- Brain injury /
- Magnesium sulfate /
- Radiation protection
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Maulik D,Qayyum I,Powell SR,et al.Post-hypoxic magnesium decreases nuclear oxidative damage in the fetal guinea pig brain.Brain Res,2001,890(1):130-136.
[2]	Esen F,Erdem T,Aktan D,et al.Effects of magnesium administration on brain edema and blood-brain barrier breakdown after experimental traumatic brain injury in rats.J Neurosurg Anesthesial,2003,15(2):119-125.
[3]	涂彧,周菊英,王利利.MgSO₄对大鼠急性放射性脑损伤后钙超载的抑制作用.中华放射医学与防护杂志,2005,25(4):339-341.
[4]	Vink R,Cernak I.Regulation of intracellular free magnesium in central nervous system injury.Front Biosci,2000,5:D656-D665.
[5]	Spielberg H,June CH,Blair OC,et al.UV irradiation of lymphocytes triggers an increase in intracellular Ca²⁺ and prevents lectin-stiraulated Ca²⁺ mobilization:evidence for UVand nifedipine-sensitive Ca²⁺ channels.Exp Hematol,1991,19(8):742-748.
[6]	Regan RF,Jasper E,Guo Y,et al.The effect of magnesium on oxidative neuronal injury in vitro.J Neurohem,1998,70(1):77-85.
[7]	Kim JH,Brown SL,Jenrow KA,et al.Mechanisms of radiationinduced brain toxicity and implications for future clinical trials.J Neurooncol,2008,87(3):279-286.
[8]	Wong CS,Van der Kogel AJ.Mechanisms of radiation injury to the central nervous system:implications for neuroprotection.Mol Interv,2004,4(5):273-284.
[9]	Tsujino K,Kodama A,Kanaoka N,et al.Expression of pulmonary mRNA encoding ICAM-1,VCAM-1,and P-selectin following thoraeic irradiation in mice.Radiat Med,1999,17(4):283-287.
[10]	Ikeda Y,lto M,Matsuu M,et al Expression of ICAM-1 and acute inflammatory cell infiltration in the early phase of radiation colitis in rats.J Radiat Res (Tokyo),2000,41(3):279-291.
[11]	Chung KY,Chang NS,Park YK,et al.Effect of ultraviolet light on the expression of adhesion molecules and T lymphocyte adhesion to human dermal microvascular endothelial cells.Yunsei Med J,2002,43(2):165-174.
[12]	朱刚,王宪荣,王正国,朱佩芳.脑创伤早期大鼠肺组织细胞间黏附分子-1mRNA的表达及其意义.中华创伤杂志,2001,17(7):392-394.
[13]	Epperly MW,Sikora CA,DeFilippi SJ,et al.Pulmonary irradiationinduced expression of VCAM-1 and ICAM-1 is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy.Biol Blood Marrow Transplant,2002,8(4):175-187.
[14]	张玮,涂彧,王利利,等.MgSO₄对放射性脑损伤大鼠脑组织早期炎症反应的影响.辐射研究与辐射工艺学报,2009(4):234-238.
[15]	Baeuml H,Behrends U,Peter RU,et al.lonizing radiation induces,via generation of reactive oxygen intermediates,intercellular adhesion molecule-1(ICAM-1) gene transcription and NF Kappa B-like binding activity in the ICAM-1 transcriptional regulatory region.Free Radic Res,1997,27(2):127-142.
[16]	Rochelson B,Dowling O,Schwartz N,et al.Magnesium sulfate suppresses inflammatory responses by human umbilical vein endothelial cells (HuVECs) through the NFKappaB pathway.J Reprod Immunol,2007,73(2):101-107.
[17]	邱建华,冯东福,朱志安,等.硫酸镁对大鼠创伤性脑水肿的影响.中华急诊医学杂志,2002,11(2):89-91.
[18]	Dawson TM,Snyder SH.Gases as biological messengers:nitric oxide and carbon monoxide in the brain.J Neurosci,1994,14(9):5147-5159.
[19]	Salzman AL,Menconi M J,Unno N,et al.Nitric oxide dilates tight junctions and depletes ATP in cuhured Caco-2BBe intestinal epithelial monolayers.Am J Physiol,1995,268(2 Pt 1):G361-G373.
[20]	袁文佳,崔风梅,王利利,等,MgSO₄,对大鼠急性放射性脑损伤后脑细胞内Ca²⁺及脑组织NO含量的影响.辐射研究与辐射工艺学报,2009,27(1):53-56.
[21]	Josephy PD,Taylor PL,Vervaet G,et al.Screening and characterization of variant Theta-class glutathione transferases catalyzing the activation of ethylene dibromide to amutagen.Environ Mol Mutagen,2006,47(9):657-665.
[22]	刘鹊凌,孙爱民,韩永清,刘英,陈龙华,袁亚维.放射性脑损伤大鼠海马神经元P35及P25的表达.山东医药,2008,48(45):19-21.
[23]	赵康仁,李学忠,田野,周旭平.半脑照射后早期海马神经元密度的研究.中国临床神经科学,2003,11(3):263-265.
[24]	Akins PT,Liu PK,Hsu CY,et al.Immediate early gene expression in response to cerebral ischemia,Friend or foe?.Stroke,1996,27(9):1682-1687.
[25]	张玮,王利利,周菊英,等.硫酸镁对放射性脑损伤大鼠C-fos基因表达及学习记忆功能的影响.中国辐射卫生,2009,18(3):257-259.

[1]	杨美玉 , 王利利 , 涂彧 . 镁离子对放射性脑损伤的脑保护作用. 国际放射医学核医学杂志, 2010, 34(6): 363-366. doi: 10.3760/cma.j.issn.1673-4114.2010.06.012
[2]	王利利 , 涂彧 , 周菊英 , 俞志英 , 秦颂兵 , 徐晓婷 , 李莉 . 硫酸镁对大鼠急性放射性脑损伤后脂质过氧化的抑制作用. 国际放射医学核医学杂志, 2007, 31(1): 37-39,54.
[3]	吴少华 , 常华杰 , 勾文峰 , 郭江红 , 宁洪鑫 , 李祎亮 , 侯文彬 . 黄杞叶提取物对小鼠造血系统辐射损伤的防护作用. 国际放射医学核医学杂志, 2022, 46(2): 92-102. doi: 10.3760/cma.j.cn121381-202101018-00141
[4]	王欣悦 , 王月 , 李文璇 , 霍启东 , 董银萍 , 唐生安 , 李德冠 . 蔓荆子提取物对小鼠造血系统辐射损伤的防护作用. 国际放射医学核医学杂志, 2023, 47(6): 354-361. doi: 10.3760/cma.j.cn121381-202207013-00309
[5]	谭燕 , 颜高姝 , 刁鹏 , 范子煊 , 孙春堂 . 促性腺激素释放激素激动剂对辐射所致大鼠卵巢功能损伤的防护作用研究. 国际放射医学核医学杂志, 2017, 41(5): 314-320. doi: 10.3760/cma.j.issn.1673-4114.2017.05.002
[6]	于明明 , 王振光 . 创伤性脑损伤PET显像研究进展. 国际放射医学核医学杂志, 2015, 39(2): 157-160. doi: 10.3760/cma.j.issn.1673-4114.2015.02.012
[7]	牟感恩 , 贾艺悦 , 龙伟 , 李园园 , 周则卫 . 甘草甜素镁的合成及其辐射防护作用研究. 国际放射医学核医学杂志, 2018, 42(2): 148-153. doi: 10.3760/cma.j.issn.1673-4114.2018.02.009
[8]	谭燕 , 孙春堂 , 颜高姝 , 范子煊 , 刁鹏 , 彭倩 , 罗兴波 , 王卫东 . 促性腺激素释放激素拮抗剂对盆腔放疗所致卵巢功能损伤的防护作用. 国际放射医学核医学杂志, 2018, 42(5): 420-424, 435. doi: 10.3760/cma.j.issn.1673-4114.2018.05.006
[9]	郑慧芬 , 涂彧 . ¹⁸F-氟脱氧葡萄糖PET在放射性脑损伤诊断中的应用. 国际放射医学核医学杂志, 2008, 32(3): 140-143.
[10]	黄蓉蓉 , 丁桂荣 . 小胶质细胞在放射性脑损伤中的作用及其机制研究进展. 国际放射医学核医学杂志, 2021, 45(2): 124-131. doi: 10.3760/cma.j.cn121381-202005040-00018

点击查看大图

计量

文章访问数: 1764
HTML全文浏览量: 327
PDF下载量: 2

镁离子对放射性脑损伤的脑保护作用

1. 苏州大学医学部放射医学与公共卫生学院, 215123;
2. 苏州大学附属第一医院放疗科, 215123

收稿日期: 2010-05-11

关键词:

脑损伤 /
硫酸镁 /
辐射防护

摘要: 放射性腩损伤是脑部肿瘤放射治疗的严重并发症之一,近几年对Mg²⁺的研究证明了其在脑损伤中的保护作用,是目前综合性评价前景较好的神经保护剂。该文综述了放射性脑损伤后脑组织中的Mg²⁺变化情况及产生原因,并从减轻炎性反应、减轻脑水肿,抑制脂质过氧化、抗细胞凋亡,改善神经功能等方面分析了Mg²⁺对放射性脑损伤的保护机制。