摘要:
目的 比较99Tcm-二亚乙基三胺五乙酸(99Tcm-DTPA)肾动态显像和血清胱抑素C测定两种方法在评价肾小球滤过功能中的差别。方法 随机抽取100例患者,其中高血压病患者38例、肾脏病患者35例、动脉硬化性闭塞症患者10例、糖尿病患者9例、其他疾病患者8例。分别通过99Tcm-DTPA肾动态显像法和血清胱抑素C测定法评估肾小球滤过功能。结果 两种方法所测得的肾小球滤过率(GFR)差异无统计学意义(t=1.591,P>0.05),且呈线性相关(r=0.809,P<0.01);放射性核素肾动态显像法在测定GFR的同时,还可以获得分肾功能,观察双肾血流灌注和排泄状况。结论 用99Tcm-DTPA肾动态显像与血清胱抑素C测定两种方法评估GFR,结果无显著差异,且相关性很好。前者可以获得分肾功能,对肾功能状态的评估更为全面;而后者测定方法简便、省时,且价廉,更适合于对临床患者肾功能的筛查。
Abstract:
Objective To compare the difference between 99Tcm-diethylenetriaminepentaacetic acid (99Tcm-DTPA) renal dynamic imaging and measurement of serum cystatin C in evaluation of glomerular filtration rate (GFR).Methods One hundred patients were selected at random, 38 cases with hy-pertension, 35with nephrosis, 10 with arteriosclerosis obliterans, 9 with diabetes and 8 with other diseases. Evaluation of patients'GFR was made separately by 99Tcm-DTPA renal dynamic imaging and measurement of serum cystatin C.Results No significant difference of GFR was found between the two methods (t=1.591, P>0.05),and linear correlation was showed as well (r=0.809, P<0.01). The imaging also revealed the function of individaul kidney, renal blood perfusion and excretory function besides GFR.Conclusion s Results of GFR from the two methods revealed no significant difference and they were highly correlated. 99Tcm-DTPA renal dynamic imaging could reveal the individual renal function and provide a more comprehensive evaluation of renal function while the measurement of serum cystatin C was simple and convenient, timesaving, economic, and more suit-able for screening patients'renal function clinically.
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