18F-FDG PET与MRI联合检测颈动脉易损斑块的应用前景

王甜甜 赵晋华

引用本文:
Citation:

18F-FDG PET与MRI联合检测颈动脉易损斑块的应用前景

Potential application of detection vulnerable plaque with 18F-FDG PET and MRI

  • 摘要: 颈动脉粥样硬化斑块的破裂是导致脑卒中发生的主要原因。利用18F-FDG PET联合MRI的方法可以同时提供斑块代谢、形态及成分方面的信息,大大提高诊断的灵敏度和特异性。
  • [1] Lloyd-Jones D, Adams R J, Brown TM, et al. Executive summary:heart disease and stroke statistics——2010 update:a report from the American Heart Association. Circulation, 201 O, 12 l(7):948-954.
    [2] 管阳太.动脉粥样硬化血栓形成与脑卒中的抗血小板治疗.上海医学,2009(4):271-275.
    [3] Libby P. Current concepts of the pathogenesis of the acute coronary. syndromes. Circulation, 2001, 104(3):365-372.
    [4] Cheng C, Tempel D, van Haperen R, et al. Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. Circulation, 2006, 113(23):2744-2753.
    [5] Muller JE, Toiler GH. Triggering and hourly variation of onset of arterial thrombosis. Ann Epidemiol, 1992, 2(4):393-405.
    [6] Muller JE, Kaufnmnn PG, Luepker RV, et al. Mechanisms precipitating acute cardiac events:review and recommendations of an NHLBI workshop. National Heart, Lung, and Blood Institute. Mechanisms precipitating acute cardiac events participants. Circulation, 1997, 96(9):3233-3239.
    [7] Matter CM, Stuber M, Nahrendorf M. Imaging of the unstable plaque:how far have we got?. Eur Heart J, 2009, 30(21):2566-2574.
    [8] 宋桂芹,王拥军.识别易损斑块的影像技术.中华老年心脑血管病杂志,2008,10(11):875-877.
    [9] Budoff M J, Achenbach S, Blumenthal RS, et al. Assessment of coronary artery disease by cardiac computed tomography:a scientific statement from the American Heart Association Committee on Cardiovascular Imaging and Intervention, Council on Cardiovascular Radiology and Intervention, and Committee on Cardiac Imaging, Council on Clinical Cardiology. Circulation, 2006, 114(16):1761-1791.
    [10] Ohtsuki K, Hayase M, Akashi K, et al. Detection of monocyte chemoattractant protein-1 receptor expression in experimental atherosclerotie lesions:an autoradiographic study. Circulation, 2001, 104(2):203-208.
    [11] Iuliano L, Signore A, Vallabajosula S, et al. Preparation and biodistribution of 99m technetium labelled oxidized LDL in man. Atherosclerosis, 1996, 126(1):131-141.
    [12] Johnson LL, Sehofield L, Donahay T, et al. ^99mTc-annexin V imaging for in vivo detection of atherosclero'de lesions in porcine coronary arteries. J Nuel Med, 2005, 46(7):1186-1193.
    [13] Kietselaer BL, Reutelingsperger CP, Heidendal GA, et al. Noninvasive detection of plaque instability with use of radiolabeled annexin A5 patients with carotid-artery atheroselerosis. N Engl J Med, 2004, 350(14):1472-1473.
    [14] Ogawa M, Ishino S, Mukai T, et al. (18)F-FDG accumulation in atherosclerotie plaques:immunohistoehemieal and PET imaging study. J Nuel Med, 2004, 45(7):1245-1250.
    [15] Tawakol A, Migrino RQ, Hoffmann U, et al. Noninvasive in vivomeasurement of vascular inflammation with F-18 fluorodeoxyglucose positron emission tomography. J Nucl Cardiol, 2005, 12(3):294301.
    [16] Tawakol A, Migrino RQ, Bashian GG, et al. In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients. J Am Coil Cardiol, 2006, 48(9):1818-1824.
    [17] Laurberg JM, Olsen AK, Hansen SB, et al. Imaging of vulnerable atheroscterotic plaques with FDG-microPET:No FDG accumulation. Atherosclerosis, 2007, 192(2):275-282.
    [18] Manieri M, Murano I, Fianchini A, et ah Morphological and immunohistochemicat features of brown adipocytes and preadipocytes in a case of human hibernoma. Nutr Metab Cardiovasc Dis, 2010, 20(8):567-574.
    [19] Nedergaard J, Bengtsson T, Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab, 2007, 293(2):E444-E452.
    [20] Graebe M, Pedersen SF, Borgwardt L, et al. Moleeular pathology in vulnerable carotid plaques:correlation with[18]-fluorodeoxvglucose positron emission tomography (FDG-PET). Eur J Vasc Endovasc Surg, 2009, 37(6):714-721.
    [21] Yuan C, Kerwin WS, Yarnykh VL, et al. MRI of atherosclerosis in clinical trials. NMR Biomed, 2006, 19(6):636-654.
    [22] Yuan C, Oikawa M, Miller Z, et al. MRI of carotid atherosclerosis. J Nucl Cardiol, 2008, 15(2):266-275.
    [23] Chu B, Kampschulte A, Ferguson MS, et al. Hemorrhage in the atherosclerotic carotid plaque:a high-resolution MRI study. Stroke, 2004, 35(5):1079-1084.
    [24] Cai JM, Hatsukami TS, Ferguson MS, et al. Classification of human carotid atherosclerotic lesions with in vivo muhicontrast magnetic resonance imaging. Circulation, 2002, 106(11):1368-1373.
    [25] 赵辉林,许建荣.3.0T高分辨MRI对颈动脉斑块分型的研究.中国医学计算机成像杂志,2007,13(3):158-162.
    [26] Yarnykh VL, Terashima M, Hayes CE, et al. Muhicontrast blackblood MR/of carotid arter/es:comparison between 1.5 and 3 tesla magnetic field strengths. J Magn Resort Imaging, 2006, 23(5):691-698.
    [27] Redgrave JN, Gallagher P, Lovett JK, et al. Critical cap thickness and rupture in symptomatic carotid plaques:The oxford plaque study. Stroke, 2008, 39(6):1722-1729.
    [28] No authors listed. Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. JAMA, 1995,273(18):1421-1428.
    [29] European Carotid Surgery Trialists' Collaborative Group. Randomised trial of endarterectomy for recently symptonmtic carotid stenosis:final results of the MRC European Carotid Surgery Trial (ECST). Lancet, 1998, 351(9113):1379-1387.
  • [1] 王甜甜赵晋华18F-FDG PET与MRI联合检测颈动脉易损斑块的应用前景. 国际放射医学核医学杂志, 2010, 34(6): 343-347. doi: 10.3760/cma.j.issn.1673-4114.2010.06.006
    [2] 吴曙黄娟胡佳圆常嫣格焦晟赵锡海宋焱 . 基于CARE-Ⅱ的颈动脉轻度狭窄患者易损斑块人群分布研究. 国际放射医学核医学杂志, 2024, 48(): 1-9. doi: 10.3760/cma.j.cn121381-202403013-00401
    [3] 刘纯宝兰晓莉张永学 . 粥样硬化易损斑块传统影像与分子影像检测与评价现状. 国际放射医学核医学杂志, 2014, 38(2): 101-105, 134. doi: 10.3760/cma.j.issn.1673-4114.2014.02.008
    [4] 冯彦林袁建伟余丰文刘德军温广华贺小红黄克敏18F-氟脱氧葡萄糖PET-CT诊断主动脉壁粥样硬化斑块的价值探讨. 国际放射医学核医学杂志, 2007, 31(2): 83-85.
    [5] 于军张莺任东栋陈聪李洋任春玲蔡君18F-FDG PET/CT与PET/MRI在结直肠癌肝转移诊断中的比较分析. 国际放射医学核医学杂志, 2021, 45(2): 75-82. doi: 10.3760/cma.j.cn121381-202003009-00013
    [6] 王蓉籍庆余杜娇刘晓林穆耀强李林涛张永春孙凯 . 第三代双源低剂量CT心脑血管一体化成像评价斑块易损性及其早期预警价值的研究. 国际放射医学核医学杂志, 2023, 47(4): 201-210. doi: 10.3760/cma.j.cn121381-202104020-00286
    [7] 袁建伟杨劼贺小红张培培肖菊梅王颖18F-FDG PET/CT与3.0T MRI联合显像在乳腺癌原发病灶诊断中的价值. 国际放射医学核医学杂志, 2013, 37(4): 199-202. doi: 10.3760/cma.j.issn.1673-4114.2013.04.003
    [8] 田亚东袁卫红 . 影像学及肿瘤相关抗原在诊断肺癌中的应用. 国际放射医学核医学杂志, 2011, 35(5): 295-299. doi: 10.3760/cma.j.issn.1673-4114.2011.05.011
    [9] 郑玉民颜珏18F-氟脱氧葡萄糖PET在恶性淋巴瘤中的应用. 国际放射医学核医学杂志, 2008, 32(6): 347-351.
    [10] 王蓉孙凯 . 冠状动脉CT诊断斑块性病变的无创影像学进展. 国际放射医学核医学杂志, 2017, 41(6): 448-451. doi: 10.3760/cma.j.issn.1673-4114.2017.06.012
    [11] 张政胡晨曦赵军18F-FDG PET/MRI在存活心肌诊断中的研究进展. 国际放射医学核医学杂志, 2023, 47(9): 568-572. doi: 10.3760/cma.j.cn121381-202302015-00342
  • 加载中
计量
  • 文章访问数:  1555
  • HTML全文浏览量:  233
  • PDF下载量:  2
出版历程
  • 收稿日期:  2010-09-06

18F-FDG PET与MRI联合检测颈动脉易损斑块的应用前景

  • 上海交通大学附属第一人民医院核医学科, 200080

摘要: 颈动脉粥样硬化斑块的破裂是导致脑卒中发生的主要原因。利用18F-FDG PET联合MRI的方法可以同时提供斑块代谢、形态及成分方面的信息,大大提高诊断的灵敏度和特异性。

English Abstract

参考文献 (29)

目录

    /

    返回文章
    返回