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小动物PET可在临床前显像研究中无创、序贯分析活体动物的功能和生理过程。18F-FDG是PET最常用的显像剂,脑对18F-FDG的摄取依赖于脑神经元的功能状态[1],并受血糖的竞争性抑制等因素影响,各脑区的放射性活度与该区的葡萄糖摄取和代谢呈正相关。啮齿动物PET脑显像获取的特定疾病信息与图像数据的可靠性密切相关,显像期间的实验条件(如动物的饮食、麻醉、显像剂的给药途径、温度和光照等)可能会影响PET图像质量[2]。因此,解决因动物实验条件控制不当而导致的图像质量不佳以使显像程序标准化至关重要。
啮齿动物18F-FDG脑摄取影响因素的分析
Analysis of the influencing factors of 18F-FDG uptake in the brain of rodents
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摘要: 小动物18F-氟脱氧葡萄糖(FDG)PET脑显像是脑科学基础研究的重要手段。在动物实验中,饮食、麻醉、显像剂的给药途径、温度及光照等实验条件均会影响其脑部活动,使脑灌注和代谢显像出现整体偏倚,进而影响对脑认知功能的判断。笔者就啮齿动物显像研究中不同实验条件对18F-FDG脑摄取的影响进行综述,为动物显像研究提供指导。
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关键词:
- 氟脱氧葡萄糖F18 /
- 正电子发射断层显像术 /
- 啮齿目 /
- 脑显像
Abstract: 18F-fluorodeoxyglucose (FDG) micro-PET brain imaging is an important means of basic research in brain science. In animal experiments, brain activity is affected by experimental conditions such as diet, anesthesia, administration route of imaging agents, temperature and light. As a result, there will be deviation in cerebral perfusion and metabolic imaging, which will affect the evaluation of brain cognitive function. The authors review the effects of different experimental conditions on the brain uptake of 18F-FDG in rodent imaging studies, and provide guidance for animal imaging research.-
Key words:
- Fluorodeoxyglucose F18 /
- Positron-emission tomography /
- Rodentia /
- Brain imaging
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