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转化生长因子β1(transforming growth factor,TGF-β1)是一种重要的成纤维细胞因子,参与体内众多生理过程。有研究结果显示,TGF-β1在创面的愈合过程中至关重要,可刺激大量基质分子沉积和微血管生成,是导致纤维化疾病发生、病理性瘢痕增生的重要介质[1]。
我国肺癌及乳腺癌等胸部肿瘤的发病率居高不下,而放疗作为治疗肿瘤的主要手段之一,经济有效且能明显提高患者5年治愈率[2]。在放疗过程中,肺作为受胸部放疗影响较大的器官,其自我修复能力相对较差,不能耐受高剂量的放疗[3]。放射性肺损伤(radiation-induced lung injury,RILI)在胸部肿瘤的治疗过程中发生率极高,绝大多数接受胸部照射的患者都会出现一定的症状,使其生存率大大降低,这对当前胸部肿瘤的治疗提出了极大的挑战[4]。放射性肺纤维化(radiation-induced pulmonary fibrosis,RIPF)是RILI的严重后果,其发生发展过程受到广泛关注。TGF-β1在RILI的发生发展中发挥着重要作用,但其具体的作用机制尚不清楚,我们对TGF-β1在RILI过程中的促纤维化作用及其机制的前沿进展进行综述。
TGF-β1在放射性肺损伤中的促纤维化作用及其机制
Profibrotic effect and mechanism of TGF-β1 in radiation lung injury
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摘要: 转化生长因子β1(TGF-β1)是一种重要的成纤维细胞因子,其表达水平能反映肺纤维化的严重程度。放射性肺损伤(RILI)包括早期的放射性肺炎(RP)和晚期的放射性肺纤维化(RIPF)。RP向RIPF发展的过程中伴随着TGF-β1表达水平的升高。了解及掌握TGF-β1在RP和RIPF发生、发展过程中的分子机制,对于RILI的防治具有重要意义。笔者就TGF-β1在RILI发生过程中的促纤维化作用及其机制进行综述。Abstract: Transforming growth factor beta 1 (TGF-β1) is an important fibrogenic cytokine, and its expression level can reflect the severity of pulmonary fibrosis. Radiation-induced lung injury (RILI) includes early radiation-induced pneumonia (RP) and late radiation-induced pulmonary fibrosis (RIPF). The development of RP to RIPF is accompanied by the increase of the expression level of TGF-β1. Understanding and mastering the molecular mechanism of TGF-β1 in the occurrence and development of RP and RIPF is of great significance for the prevention and treatment of RILI. This paper reviews the fibrogenic effect of TGF-β1 in the process of RILI and its mechanism.
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