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血管肉瘤是一类起源于血管或淋巴管内皮细胞的高度恶性的软组织肿瘤,仅占软组织肉瘤的1%~2%[1],为软组织肉瘤中进展最快的恶性肿瘤。上皮样血管肉瘤(epithelioid angiosarcoma,EA)是血管肉瘤的特殊类型,好发于皮肤或软组织,极少发生于脏器,易复发,其转移部位常见于肺、骨、淋巴结、脑、肝脏,极少转移至小肠。EA细胞具有上皮样特征,与低分化癌或其他软组织肿瘤鉴别诊断较为困难,心脏EA更是少见且预后不佳。18F-FDG PET/CT检查可初步鉴别肿瘤的良恶性,对心脏肿瘤进行早期诊断,并了解全身转移病灶情况,从而进行准确分期,为临床治疗提供参考依据。本文通过对1例心脏EA伴全身广泛转移患者的临床资料及18F-FDG PET/CT影像资料进行分析,结合文献总结其影像学特征,以提高对该病的认识。
18F-FDG PET/CT诊断心脏上皮样血管肉瘤伴广泛转移一例并文献复习
A case of 18F-FDG PET/CT diagnosis of cardiac epithelioid angiosarcoma with extensive metastasis and literature review
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摘要: 笔者报道了1例心脏上皮样血管肉瘤(EA)伴广泛转移的18F-氟脱氧葡萄糖(FDG) PET/CT显像病例,分别从临床症状、实验室检查、心脏超声、CT 、MRI及18F-FDG PET/CT显像等方面分析了EA的特点,并通过文献回顾总结了心脏EA的影像学特征。心脏EA在临床上不常见,18F-FDG PET/CT显像对其的诊断及临床分期具有一定的临床意义。Abstract: The authors reported a case of cardiac epithelioid angiosarcoma (EA) with extensive metastasis on 18F-fluorodeoxyglucose (FDG) PET/CT imaging. The characteristics of EA were analyzed from clinical symptoms, laboratory examinations, ultrasound, CT, MRI and 18F-FDG PET/CT whole-body imaging, and the imaging features of cardiac epithelioid angiosarcoma were summarized through literature review. Cardiac EA is rarely seen in clinic, and 18F-FDG PET/CT imaging has certain clinical significance in the diagnosis and clinical staging of EA.
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图 2 心脏上皮样血管肉瘤伴多发转移性患者(女性,50岁)的组织病理学检查和免疫组织化学检查图 A为上皮样血管肉瘤的组织病理学检查(苏木精-伊红,×100),腹腔(升结肠周围)淋巴结穿刺,考虑为间叶性恶性肿瘤,癌细胞弥漫片状排列,核分裂易见;B为免疫组织化学染色法(×40),上皮样血管肉瘤(差分化),考虑来源心脏
Figure 2. Histopathological examination and immunohistochemistry images of the patient with cardiac epithelioid hemangiosarcoma with extensive metastasis (female, 50 years old)
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[1] 丁祺, 宋旭东, 祁秀敏, 等. 上皮样血管肉瘤6例及文献复习[J]. 实用肿瘤杂志, 2020, 35(3): 265−269. DOI: 10.13267/j.cnki.syzlzz.2020.03.015.
Ding Q, Song XD, Qi XM, et al. Epithelioid angiosarcoma in 6 cases and literature review[J]. J Pract Oncol, 2020, 35(3): 265−269. DOI: 10.13267/j.cnki.syzlzz.2020.03.015.[2] Yanagawa B, Mazine A, Chan EY, et al. Surgery for tumors of the heart[J]. Semin Thorac Cardiovasc Surg, 2018, 30(4): 385−397. DOI: 10.1053/j.semtcvs.2018.09.001. [3] 李学军, 胡选义, 吴观生, 等. 心脏原发性肿瘤临床以及病理分析[J]. 中国公共卫生, 2015, 31(A01): 189.
Li XJ, Hu XY, Wu GS, et al. Clinical and pathological analysis of primary cardiac neoplasms[J]. Chin J Public Health, 2015, 31(A01): 189.[4] Hudzik B, Miszalski-Jamka K, Glowacki J, et al. Malignant tumors of the heart[J]. Cancer Epidemiol, 2015, 39(5): 665−672. DOI: 10.1016/j.canep.2015.07.007. [5] 姚丽锭, 张敏鸣, 王丽华. 原发性心脏血管肉瘤影像表现二例[J]. 中华放射学杂志, 2015, 49(2): 148−149. DOI: 10.3760/cma.j.issn.1005-1201.2015.02.018.
Yao LD, Zhang MM, Wang LH. Imaging findings of primary cardiac angiosarcoma: two cases[J]. Chin J Radiol, 2015, 49(2): 148−149. DOI: 10.3760/cma.j.issn.1005-1201.2015.02.018.[6] 肖新华, 李景雷, 刘彬, 等. 原发性心脏血管肉瘤的CT及MRI表现[J]. 中国中西医结合影像学杂志, 2015, 13(1): 7−12. DOI: 10.3969/j.issn.1672-0512.2015.01.003.
Xiao XH, Li JL, Liu B, et al. CT and MRI appearance of primary cardiac angiosarcoma[J]. Chin Imaging J Integr Tradit Western Med, 2015, 13(1): 7−12. DOI: 10.3969/j.issn.1672-0512.2015.01.003.[7] 王敏, 郭启勇. 心脏原发性血管肉瘤肺转移1例报道[J]. 现代肿瘤医学, 2019, 27(18): 3308−3311. DOI: 10.3969/j.issn.1672-4992.2019.18.034.
Wang M, Guo QY. Primary cardiac angiosarcoma with pulmonary metastases: a case report[J]. J Mod Oncol, 2019, 27(18): 3308−3311. DOI: 10.3969/j.issn.1672-4992.2019.18.034.[8] 卢霞, 孟晶晶, 焦建, 等. 18F-FDG PET/CT在心脏肿瘤诊断的临床应用价值[J]. 中华核医学与分子影像杂志, 2017, 23(6): 474−478. DOI: 10.11735/j.issn.1671-170X.2017.06.B004.
Lu X, Meng JJ, Jiao J, et al. Clinical application of 18F-FDG PET/CT in diagnosis of cardiac neoplasm[J]. Chin J Nucl Med Mol Imaging, 2017, 23(6): 474−478. DOI: 10.11735/j.issn.1671-170X.2017.06.B004.[9] 张智旸, 高鑫, 白春梅, 等. 心脏原发性血管肉瘤16例的临床影像特征及预后分析[J]. 中华心血管病杂志, 2019, 47(9): 731−736. DOI: 10.3760/cma.j.issn.0253-3758.2019.09.015.
Zhang ZY, Gao X, Bai CM, et al. Clinical and radiologic characteristics as well as outcomes of patients with primary cardiac angiosarcoma[J]. Chin J Cardiol, 2019, 47(9): 731−736. DOI: 10.3760/cma.j.issn.0253-3758.2019.09.015.[10] 范茜茜, 杨炼, 柳曦, 等. 原发性心脏血管肉瘤伴双肺转移影像表现并文献分析[J]. 中国中西医结合影像学杂志, 2016, 14(1): 50−52. DOI: 10.3969/j.issn.1672-0512.2016.01.015.
Fan QQ, Yang L, Liu X, et al. Imaging findings and literature analysis of primary cardiac angiosarcoma with bilateral lung metastasis[J]. Chin Imaging J Integr Tradit Western Med, 2016, 14(1): 50−52. DOI: 10.3969/j.issn.1672-0512.2016.01.015.[11] 张永远, 王猛, 周志刚. 四例心脏原发性血管肉瘤的影像表现及文献回顾[J]. 中华放射学杂志, 2018, 52(9): 701−703. DOI: 10.3760/cma.j.issn.1005-1201.2018.09.011.
Zhang YY, Wang M, Zhou ZG. Imaging findings and literature review of four cases of primary angiosarcoma of the heart[J]. Chin J Radiol, 2018, 52(9): 701−703. DOI: 10.3760/cma.j.issn.1005-1201.2018.09.011.[12] 颜临丽, 宋征, 王映梅, 等. 原发性心脏肉瘤8例临床病理分析[J]. 现代肿瘤医学, 2018, 26(16): 2524−2528. DOI: 10.3969/j.issn.1672-4992.2018.16.010.
Yan LL, Song Z, Wang YM, et al. Report and clinicopathologic study of 8 cases of primary cardiac sarcomas[J]. J Mod Oncol, 2018, 26(16): 2524−2528. DOI: 10.3969/j.issn.1672-4992.2018.16.010.[13] 袁明明, 任晓燕, 赵一诺, 等. 小肠转移性上皮样血管肉瘤1例临床病理分析[J]. 临床与实验病理学杂志, 2018, 34(7): 802−804. DOI: 10.13315/j.cnki.cjcep.2018.07.025.
Yuan MM, Ren XY, Zhao YN, et al. Clinicopathological analysis of 1 case with metastatic epithelioid angiosarcoma of small intestine[J]. J Clin Exp Pathol, 2018, 34(7): 802−804. DOI: 10.13315/j.cnki.cjcep.2018.07.025.[14] 魏建国, 唐锦龙, 杨烨, 等. 胃肠道上皮样血管肉瘤四例临床病理学观察[J]. 中华病理学杂志, 2020, 49(2): 177−179. DOI: 10.3760/cma.j.issn.0529-5807.2020.02.014.
Wei JG, Tang JL, Yang Y, et al. Clinicopathological features of gastrointestinal tract epithelioid angiosarcoma[J]. Chin J Pathol, 2020, 49(2): 177−179. DOI: 10.3760/cma.j.issn.0529-5807.2020.02.014.[15] 肖德贤, 严茂林, 黄龙. 大网膜上皮样血管肉瘤的诊断与治疗[J]. 中华消化外科杂志, 2016, 15(10): 1026−1028. DOI: 10.3760/cma.j.issn.1673-9752.2016.10.016.
Xiao DX, Yan ML, Huang L. Diagnosis and treatment of greater omental epithelioid angiosarcoma[J]. Chin J Dig Surg, 2016, 15(10): 1026−1028. DOI: 10.3760/cma.j.issn.1673-9752.2016.10.016.[16] Elbardissi AW, Dearani JA, Daly RC, et al. Survival after resection of primary cardiac tumors: a 48-year experience[J]. Circulation, 2008, 118(14 Suppl 1): S7−15. [17] 孙晓昕, 何作祥, 张晓丽, 等. 18F-FDG PET/CT在心脏占位性病变良恶性鉴别诊断中的应用[J]. 中华核医学与分子影像杂志, 2015, 35(2): 85−87. DOI: 10.3760/cma.j.issn.2095-2848.2015.02.002.
Sun XX, He ZX, Zhang XL, et al. Diagnostic value of 18F-FDG PET/CT in differentiating the cardiac benign from malignant lesions[J]. Chin J Nucl Med Mol Imaging, 2015, 35(2): 85−87. DOI: 10.3760/cma.j.issn.2095-2848.2015.02.002.[18] Rahbar K, Seifarth H, Schäfers M, et al. Differentiation of malignant and benign cardiac tumors using 18F-FDG PET/CT[J]. J Nucl Med, 2012, 53(6): 856−863. DOI: 10.2967/jnumed.111.095364.