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乏氧是影响肿瘤微环境的重要因素之一,是恶性肿瘤的标志,其可通过多种机制使肿瘤细胞适应所处的环境,具有更强的生存能力和侵袭性,并对放疗产生抵抗。血管生成素样蛋白(angiopoietin-like proteins,ANGPTLs)被认为是调控血管生成的决定性因子,其作为炎症致癌介质,以自分泌和旁分泌的方式参与血管生成、慢性炎症发生和肿瘤发生发展的不同阶段。虽然ANGPTLs在肿瘤中的作用尚未完全阐明,但越来越多的证据表明,其在几种侵袭性实体肿瘤中普遍高表达,且在肿瘤细胞的增殖和侵袭中起关键作用[1]。鉴于ANGPTLs在肿瘤细胞和肿瘤微环境中的作用,其具有成为预测肿瘤及其治愈后的生物标志物的潜力,并可作为肿瘤治疗的新靶点。此外,ANGPTLs可能在乏氧诱导的辐射抵抗中发挥重要作用,从而影响肿瘤的治疗效果。本文就ANGPTLs家族的生物学特性、在肿瘤发展以及肿瘤乏氧微环境中可能的作用进行概述。
血管生成素样蛋白在肿瘤发生发展中的作用
Role of angiogenin-like proteins in tumorigenesis and development
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摘要: 血管生成素样蛋白(ANGPTLs)是一类与血管生成素结构相似的分泌型糖蛋白,其在实体肿瘤的侵袭转移、血管生成、细胞凋亡等过程中发挥重要的调节作用。局部乏氧是肿瘤微环境最突出的特征,其介导多个生物学过程,进而影响肿瘤的进展以及治疗效果。ANGPTLs家族中的部分蛋白可作为乏氧诱导因子1的下游靶基因,调节肿瘤的生理功能。因此,阐明ANGPTLs在肿瘤中的作用及其机制对提高肿瘤治愈率和改善患者预后具有重要意义。笔者概述了ANGPTLs家族的生物学特征、在肿瘤发生发展以及肿瘤乏氧微环境中可能的作用。
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关键词:
- 血管生成素样蛋白质类 /
- 肿瘤发生 /
- 肿瘤发展 /
- 乏氧微环境
Abstract: Angiopoietin-like proteins (ANGPTLs), a class of secreted glycoproteins with a similar structure to angiopoietin, play a pivotal role in solid tumors invasion, metastasis, angiogenesis and apoptosis. As the prominent feature of the tumor microenvironment, hypoxia affects tumor progression and therapeutic effect through mediating multiple biological processes. Some ANGPTLs can act as downstream target genes of hypoxia-inducible factor 1 to regulate tumor physiological functions. Therefore, elucidating the effect and mechanism of ANGPTLs in tumor is of essential significance for improving the tumor cure rate and prognosis. In this article, a brief outline of the biological characteristics of the ANGPTLs family and their possible roles in tumorigenesis, development and hypoxic microenviroment is presented.-
Key words:
- Angiopoietin-like proteins /
- Tumorigenesis /
- Tumor development /
- Hypoxic microenvironment
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