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多发性骨髓瘤(multiple myeloma,MM)是一种浆细胞异常增生的恶性疾病,多发于老年人。据预测,随着人口老龄化的发展,MM在我国的发病率将迅速增长并将成为影响国民健康的重大疾病之一[1]。目前,虽无完全治愈MM的办法,但随着医疗技术水平的提高、更多诊断手段的普及和各种新型药物的上市,MM的诊疗水平也逐步提高。我们就18F-FDG PET/CT显像在MM诊疗中的应用进展进行综述。
18F-FDG PET/CT显像在多发性骨髓瘤诊疗中的研究进展
Research progress of 18F-FDG PET/CT imaging in the diagnosis and treatment of multiple myeloma
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摘要: 多发性骨髓瘤(MM)是一种克隆性浆细胞异常增生的恶性疾病,多发于老年人,其发病率居恶性血液病的第二位,目前在我国其发病率呈逐年上升的趋势。18F-氟脱氧葡萄糖(FDG)PET/CT显像能够在分子水平上提供恶性肿瘤的增殖和代谢情况等信息,已有的研究结果表明,其在MM的诊断、分期、疗效监测和预后评估等方面具有重要意义。笔者对18F-FDG PET/CT显像在MM诊疗中的研究进展进行综述。
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关键词:
- 多发性骨髓瘤 /
- 氟脱氧葡萄糖F18 /
- 正电子发射断层显像术 /
- 体层摄影术,X线计算机 /
- 诊断 /
- 治疗应用
Abstract: Multiple myeloma (MM) is a malignant disease of clonal plasma cell hyperplasia, which occurs mostly in the elderly. The incidence of MM ranks second in hematological malignancies and is currently on the rise in China year by year. 18F-fluorodeoxyglucose (FDG) PET/CT imaging can provide information on the proliferation and metabolism of malignant tumors at the molecular level. Existing studies have proved that 18F-FDG PET/CT is of great significance in the diagnosis, staging, monitoring of efficacy and prognostic evaluation of MM. This paper reviews the research progress of 18F-FDG PET/CT imaging in the diagnosis and treatment of MM. -
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