Abstract: Bone metastasis is a common complication of advanced tumors. Severe pain frequently leads to a decline in quality of life and tendency toward bone-related adverse events, such as pathological fractures, spinal cord compression, and hypercalcemia. To alleviate pain caused by mild to moderate bone metastases, conventional analgesic or external radiation therapy can be used. However, when multiple body metastases and severe pain occur, the two aforementioned methods become ineffective and cause serious side effects. Some radionuclides can be specifically taken up by activated osteoblasts and can be retained in bone tissues for a long time. Therefore, systematic treatment with several new bone-targeting radionuclides, such as ⁸⁹Sr, ¹⁵³Sm, and ¹⁸⁶Re, has become a new approach for providing additional targets and a safe and effective treatment for bone metastases.