[1]

Combs SE, Habermehl D, Kieser M, et al.Phase I study evaluating the treatment of patients with locally advanced pancreatic cancer with Carbon ion radiotherapy: the PHOENIX-01 trial[J/OL].BMC Cancer, 2013, 13: 419[2016-03-09].http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849371/.DOI: 10.1186/1471-2407-13-419.

[2] Antonovic L, Brahme A, Furusawa Y, et al.Radiobiological description of the LET dependence of the cell survival of oxic and anoxic cells irradiated by carbon ions[J].J Radiat Res, 2013, 54(1):18-26.DOI:10.1093/jrr/rrs070.
[3] 瞿海燕, 辛小萍, 马建霞.重离子治癌技术专利发展态势分析[J].科学观察, 2015, 10(1):11-23.DOI:10.15978/j.cnki.1673-5668.201501002.
Huo HY, Xin XP, Ma JX.International development trend analysis for patented technology of the heavy-ion cancer therapy[J].Sci Focus, 2015, 10(1):11-23.DOI:10.15978/j.cnki.1673-5668.201501002.
[4] Miyamoto T, Baba M, Yamamoto N, et al.Curative treatment of Stage I non-small-cell lung cancer with carbon ion beams using a hypofractionated regimen[J].Int J Radiat Oncol Biol Phys, 2007, 67(3):750-758.DOI:10.1016/j.ijrobp.2006.10.006.
[5] 王岚, 戴小亚.全球质子重离子医院现状与展望[J].中国医院建筑与装备, 2016, 15(1):27-31.
Wang L, Dai XY.A review of global particle therapy centers[J].Chin Hospital Architect Equip, 2016, 15(1):27-31.
[6] 刘锐锋, 张秋宁, 高力英, 等.重离子束(12C6+)治疗肝脏恶性肿瘤的初步临床结果[J].辐射研究与辐射工艺学报, 2014, 32(1):1-8.
Liu RF, Zhang QN, Gao LY, et al.A preliminary clinical efficacy of heavy ion(12C6+) beam for hepatic malignance[J].J Radiat Res Radiat Process, 2014, 32(1):1-8.
[7]

张健.重离子辐射生物学效应评估模型的研究[D].大连: 大连海事大学, 2012.

Zhan J.Studies on evaluation models for biological effects of heavy-ion radiation[D].Dalian: Dalian Maritime University, 2012.

[8] Haettner E, Iwase H, Krämer M, et al.Experimental study of nuclear fragmentation of 200 and 400 MeV/u (12)C ions in water for applications in particle therapy[J].Phys Med Biol, 2013, 58(23):8265-8279.DOI:10.1088/0031-9155/58/23/8265.
[9]

Durante M.New challenges in high-energy particle radiobiology[J/OL].Br J Radiol, 2014, 87(1035): 20130626.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064605.DOI: 10.1259/bjr.20130626.

[10] Ashley L, Michel M, Ying Y, et al.Radiation-induced signaling pathways that promote cancer cell survival[J].Int J Oncol, 2014, 45(5):1813-1819.DOI:10.3892/ijo.2014.2614.
[11] 郭妍宏, 朱应葆.DNA损伤检验点调控的分子机制[J].生理科学进展, 2007, 38(3):208-212.  doi: 10.3321/j.issn:0559-7765.2007.03.004
Guo YH, Zhu YB.The mechanism of DNA damage checkpoint control[J].Progress Physiol Sci, 2007, 38(3):208-212.  doi: 10.3321/j.issn:0559-7765.2007.03.004
[12] Cuadrado M, Martinez-Pastor B, Murga M, et al.ATM regulates ATR chromatin loading in response to DNA double-strand breaks[J].J Exp Med, 2006, 203(2):297-303.DOI:10.1084/jem.20051923.
[13]

Ghorai A, Bhattacharyya NP, Sarma A, et al.Radiosensitivity and induction of apoptosis by high LET Carbon ion beam and low LET gamma radiation: a comparative study[J/OL].Scientifica, 2014, 2014: 438030[2016-03-09].http://www.hindawi.com/journals/scientifica/2014/438030/.DOI: org/10.1155/2014/438030.

[14] 刘斌, 侯玮玮, 王燕玲, 等.重离子束与X射线辐照对人舌鳞癌细胞周期影响的比较[J].现代预防医学, 2008, 35(23):4725-4727.DOI:10.3969/j.issn.1003-8507.2008.23.080.
Liu B, Hou WW, Wang YL, et al.Comparative study of 12C6+ and X-ray on cell cycle progression in the human tongue squamous cell carcinoma[J].Mod Preventive Med, 2008, 35(23):4725-4727.  doi: 10.3969/j.issn.1003-8507.2008.23.080
[15] 雷苏文.重离子辐射生物效应的实验研究[J].国外医学:放射医学核医学分册, 2002, 26(6):275-277.DOI:10.3760/cma.j.issn.1673-4114.2002.06.010.
Lei SW.The experimental study on biological effects of heavy ion radiation[J].Foreign Med Sci(Radiat Med Nucl Med), 2002, 26(6):275-277.  doi: 10.3760/cma.j.issn.1673-4114.2002.06.010
[16] 周平坤, 霍艳英, 吴德昌.辐射致癌效应与机制[J].辐射防护通讯, 2007, 27(1):7-12.DOI:10.3969/j.issn.1004-6356.2007.01.002.
Zhou PK, Huo YY, Wu DC.Radiation carcinogenesis and its mechanisms[J].Radiat Protect Bulletin, 2007, 27(1):7-12.  doi: 10.3969/j.issn.1004-6356.2007.01.002
[17] Zhou ZZ, Ware JH, Kennedy AR.Carbon and iron ion radiation-induced cytotoxicity and transformation in vitro[J].Oncol Lett, 2011, 2(5):915-918.DOI:10.3892/ol.2011.342.
[18] 黄敏, 缪泽鸿, 丁健.DNA双链断裂损伤修复系统研究进展[J].生理科学进展, 2007, 38(4):295-299.DOI:10.1093/imanum/drn068.
Huang M, Miao ZH, Ding J.Repair pathways in response to DNA double-strand breaks[J].Prog in Physiol Sci, 2007, 38(4):295-299.  doi: 10.1093/imanum/drn068
[19] Mladenov E, Iliakis G.Induction and repair of DNA double strand breaks:the increasing spectrum of non-homologous end joining pathways[J].Mutat Res, 2011, 711(1/2):61-72.DOI:10.1016/j.mrfmmm.2011.02.005.
[20] Hamada N, Imaoka T, Masunaga S, et al.Recent advances in the biology of heavy-ion cancer therapy[J].J Radiat Res, 2010, 51(4):365-383.DOI:10.1269/jrr.09137.
[21] Okayasu R.Repair of DNA damage induced by accelerated heavy ionsuA mini review[J].Inter J Cancer, 2012, 130(5):991-1000.DOI:10.1002/ijc.26445.
[22] Sekine E, Okada M, Matsufuji N, et al.High LET heavy ion radiation induces lower numbers of initial chromosome breaks with minimal repair than low LET radiation in normal human cells[J].Mutat Res, 2008, 652(1):95-101.DOI:10.1016/j.mrgentox.2008.01.003.
[23] Maalouf M, Durante M, Foray N.Biological effects of space radiation on human cells:history, advances and outcomes[J].J Radiat Res, 2011, 52(2):126-146.DOI:10.1269/jrr.10128.
[24] Pang D, Winters TA, Jung M, et al.Radiation-generated short DNA fragments May perturb non-homologous end-joining and induce genomic instability[J].J Radiat Res, 2011, 52(3):309-319.DOI:10.1269/jrr.10147.
[25] 郭传玲, 王菊芳, 魏巍, 等.高LET重离子照射人肿瘤细胞的DNA双链断裂及修复研究[J].核技术, 2007, 30(9):750-753.DOI:10.3321/j.issn:0253-3219.2007.09.007.
Guo CL, Wang JF, Wei W, et al.DNA double Strand break and repair of human tumor cells irradiated by high LET heavy ions[J].Nucl Techniques, 2007, 30(9):750-753.  doi: 10.3321/j.issn:0253-3219.2007.09.007
[26] Themis M, Garimberti E, Hill MA, et al.Reduced chromosome aberration complexity in normal human bronchial epithelial cells exposed to low-LET gamma-rays and high-LET alpha-particles[J].Int J Radiat Biol, 2013, 89(11):934-943.DOI:10.3109/09553002.2013.805889.
[27] Durante M.Biomarkers of space radiation risk[J].Radiat Res, 2005, 164(4Pt2):467-473.DOI:10.1667/RR3359.1.
[28] Pandita TK, Hall EJ, Hei TK, et al.Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny[J].Oncogene, 1996, 13(7):1423-1430.
[29] Wu H, George K, Willingham V, et al.Comparison of F ratios generated from interphase and metaphase chromosome damage induced by high doses of low-and high-LET radiation[J].Radiat Res, 2001, 155(1Pt1):57-62.
[30] Schmidt JC, Cech TR.Human telomerase:biogenesis, trafficking, recruitment, and activation[J].Genes Dev, 2015, 29(11):1095-1105.DOI:10.1101/gad.263863.115.
[31] Rankin AM, Faller DV, Spanjaard RA.Telomerase inhibitors and 'T-oligo' as cancer therapeutics:contrasting molecular mechanisms of cytotoxicity[J].Anticancer Drugs, 2008, 19(4):329-338.DOI:10.1097/CAD.0b013e3282f5d4c2.
[32] 邹跃, 周湘艳, 杜维霞, 等.电离辐射诱导端粒延长作用的研究[J].中华放射医学与防护杂志, 2005, 25(6):524-525.DOI:10.3760/cma.j.issn.0254-5098.2005.06.007.
Zou Y, Zhou XY, Du WX, et al.Study on telomere lengthening induced by radiation[J].Chin J Radiol Med Prot, 2005, 25(6):524-525.  doi: 10.3760/cma.j.issn.0254-5098.2005.06.007
[33] Millet P, Granotier C, Etienne O, et al.Radiation-induced upregulation of telomerase activity escapes PI3-kinase inhibition in two malignant glioma cell lines[J].Int J Oncol, 2013, 43(2):375-382.DOI:10.3892/ijo.2013.1970.
[34] Wang X, Liu Y, Chow LS, et al.Regulation of telomerase activity by gamma-radiation in nasopharyngeal carcinoma cells[J].Anticancer Res, 2000, 20(1A):433-437.
[35] Mirjolet C, Boidot R, Saliques S, et al.The role of telomeres in predicting individual radiosensitivity of patients with cancer in the era of personalized radiotherapy[J].Cancer Treat Rev, 2015, 41(4):354-360.DOI:10.1016/j.ctrv.2015.02.005.
[36]

Wang Y, Sun C, Mao A, et al.Radiosensitization to X-ray radiation by telomerase inhibitor MST-312 in human hepatoma HepG2 cells[J/OL].Life Sci, 2015, 123: 43-50[2016-03-01].http://www.sciencedirect.com/science/journal/00243205.DOI: 10.1016/j.lfs.2014.12.027.

[37] 潘东风, 周福祥, 谢丛华, 等.人不同乳腺癌细胞株端粒酶活性与放射敏感性的关系[J].武汉大学学报:医学版, 2004, 25(4):450-452.DOI:10.3969/j.issn.1671-8852.2004.04.027.
Pan DF, Zhou FX, Xie CH, et al.Correlation of telomerase activity with radiosensitivity in different human breast cancer cell lines[J].Med J Wuhan Univ, 2004, 25(4):450-452.  doi: 10.3969/j.issn.1671-8852.2004.04.027
[38] 胡凯骞, 党秉荣, 李文建, 等.12C6+重离子辐照对人肝细胞、肝癌细胞端粒酶活性表达的影响[J].辐射研究与辐射工艺学报, 2008, 26(3):166-170.DOI:10.3969/j.issn.1000-3436.2008.03.008.
Hu KQ, Dang BR, Li WJ, et al.The changes of telomerase activity of the human hepatocellular cells and carcinoma cells irradiated by 12C6+ ions[J].J Radiat Res Radiat Processing, 2008, 26(3):166-170.  doi: 10.3969/j.issn.1000-3436.2008.03.008
[39] Tyers M, Mann M.From genomics to proteomics[J].Nature, 2003, 422(6928):193-197.DOI:10.1038/nature01510.
[40] Kellner R.Proteomics.Concepts and perspectives[J].Fresenius J Anal Chem, 2000, 366(6/7):517-524.
[41] Lima F, Ding D, Goetz W, et al.High LET 56Fe ion irradiation induces issue-Specific Changes in DNA Methylation in the Mouse[J].Environ Mol Mutagen, 2014, 55(3):266-277.DOI:10.1002/em.21832.
[42] 王洪彬, 王潇, 王海龙, 等.PC12细胞重离子辐射生物学效应的比较蛋白质组学研究[J].化学通报, 2010, 73(11):1023-1029.DOI:10.14159/j.cnki.0441-3776.2010.11.001.
Wang HB, Wang X, Wang HL, et al.Comparative proteomics analysis of biological effects of heavy ion radiation on PC12 cells[J].Chemistry (Easton), 2010, 73(11):1023-1029.  doi: 10.14159/j.cnki.0441-3776.2010.11.001
[43] Di CX, Yang LN, Zhang H, et al.Effects of carbon-ion beam or X-ray irradiation on anti-apoptosis ΔNp73 expression in HeLa cells[J].Gene, 2013, 515(1):208-213.DOI:10.1016/j.gene.2012.11.040.
[44] Oonishi K, Cui X, Hirakawa H, et al.Different effects of Carbon ion beams and X-rays on clonogenic survival and DNA repair in human pancreatic cancer stem-like cells[J].Radiother Oncol, 2012, 105(2):258-265.DOI:org/10.1016/j.radonc.2012.08.009.
[45] Merz F, Gaunitz F, Dehghani F, et al.Organotypic slice cultures of humanglioblastoma reveal different susceptibilities to treatments[J].Neuro Oncol, 2013, 15(6):670-681.DOI:10.1093/neuonc/not003.
[46] 郭晓鹏, 张苗苗, 缪建顺, 等.重离子束辐射生物学效应研究热点及其进展[J].辐射研究与辐射工艺学报, 2015, 33(4):7-12.DOI:10.11889/j.1000-3436.2015.rrj.33.040102.
Guo XP, Zhang MM, Miao JS, et al.Research hotspots and recent progress of biological effects induced by heavy ion beam irradiation[J].J Radiat Res Radiat Processing, 2015, 33(4):7-12.  doi: 10.11889/j.1000-3436.2015.rrj.33.040102