[1] Verdile G,Fuller S,Atwood CS,et al.The role of beta amyloid in Alzheimer's disease:still a cause of everything or the only one who got caught.Pharmacol Res,2004,50(4):397-409.
[2] Court JA,Piggott MA,Lloyd S,et al.Nicotine binding in human striatum:elevation in schizophrenia and reductions in dementia with Lewy bodies,Parkinson's disease and Alzheimer's disease and in relation to neuroleptic medication.Neurosci,2000,98(1):79-87.
[3] Nora DV,Ding YS,Joanna SF,et al.Imaging brain cholinergic activity with positron emission tomography:its role in the evaluation of cholinergic treatments in Alzheimer's dementia.Biol Psychiatry,2001,49(3):211-220.
[4] De Leon MJ,Convit A,Wolf OT,et al.Prediction of cognitive decline in normal elderly subjects with 2-[18F] fluoro-2-deoxy-D-glucose/poitron-emission tomography (FDG/PET).Proc Natl Acad Sci USA,2001,98(19):10966-10971.
[5] Hard J,Selkoe DJ.The amyloid hypothesis of Alzheimer's disease:progress and problems on the road to therapeutics.Science,2002,297(5590):353-356.
[6] Zhang Y,Pavlova OA,Chefer SI,et al.5-substituted derivatives of 6-halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-halogeno-3-((2-(S)-pyrrolidinyl)methoxy) pyridine with low picomolar affinity for alpha 4 beta 2 nicotinic acetylcholine receptor and wide range of lipophilicity:potential probes for imaging with positron emission tomography.J Med Chem.2004,47(10):2453-2465.
[7] Mathis CA,Bacskai BJ,Kajdasz ST,et al.A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.Bioorg Med Chem Lett,2002,12(3):295-298.
[8] Klunk WE,Engler H,Nordberg A,et al.Imaging brain amyloid in Alzheimer's disease with pittsburgh compound-B.Ann Neurol,2004,55(3):306-319.
[9] Kung HF,Lee CW,Zhuang ZP,et al.Novel stilbenes as probes for amyloid plaques.J Am Chem Soc,2001,123(50):12740-12741.
[10] Suemoto T,Okamura N,Shiomostu T,et al.In vivo labeling of amyloid with BF-108.Neurosci Res,2004,48(1).65-74.
[11] Agdeppa ED,Kepe V,Liu J,et al.In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe2-(1-[6-[(2-[18F]fluoroethyl) (methyl)amino]-2-naphthyl] ethylidene) malononitrile.Neurosci,2003,117(3):723-730.
[12] Musachio JL,Flesher J,Scheffel UA,et al.Radiosynthesis and mouse brain distribution studies of 11C-CP-126,998:a PET ligand for in vivo study of acetylcholinesterase.Nucl Med Biol,2002,29(5):547-552.
[13] Zhang MR,Tsuchiyama A,Haradahira T,et al.Synthesis and preliminary evaluation of[18F] FEtP4A,a promising PET tracer for mapping acetylcholinesterase in vivo.Nucl Med Biol,2002,29(4):463-468.
[14] Shao X,Lisi JM,Butch ER,et al.N-[18F] fluoroethylpiperidinyl,N-[18F] fluoroethylpiperidinemethyl and N-[18F] fluoroethylpyrrolidinyl esters as radiotracers for acetylcholinesterase.Nucl Med Biol,2003,30(5):491-500.
[15] Skaddan MB,Sherman PS,Kilbourn,MR,et al.The role of species-dependent metabolism in the regional brain retention of 18F-labeled muscarinic acetylcholine receptor ligands.Nucl Med Biol,2001,28(7):753-759.
[16] Cohen VI,Jin BJ,McRee RC,et al.In vitro and in vivo m2 muscarinic subtype selectivity of some dibenzodiasepinones and pyridobenzodiazepinones.Brain Res,2000,861(2):305-315.
[17] Piggott M,Owens J,O'Brien J,et al.Comparative distribution of binding of the muscarinic receptor ligands pirenzepine,AF-DX 384,(R,R)-I-QNB and (R,S)-I-QNB to human brain.J Chem Neuroanat,2002,24(3):211-223.
[18] Koren AO,Horti AG,Mukhin AG,et al.2-,5-,and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines:synthesis,affinity for nicotinic acetylcholinereceptors,and molecular modeling.J Med Chem,1998,41(19):3690-3698.
[19] Horti AG,Chefer SL,Mukhin AG,et al.6-[18F] fluoro-A-85380,a novel radioligand for in vivo imaging of central nicotinic acetylcholine receptors.Life Sci,2000,67(4):463-469.
[20] Roger G,Lagnel B,Rouden J,et al.Synthesis of a[2-pyridinyl-18F]-labelled fluoro derivative of (-)-cytisine as a candidate radioligand for brain nicotinic alpha4beta2 receptor imaging with PET.Bioorg Med Chem,2003,11(24):5333-5343.