[1] Gilbert MR, Dignam JJ, Armstrong TS, et al. A randomized trial of bevacizumab for newly diagnosed glioblastoma[J]. N Engl J Med, 2014, 370(8):699-708.  doi: 10.1056/NEJMoa1308573
[2] Hervey-Jumper SL, Berger MS. Role of surgical resection in low- and high-grade gliomas[J]. Curr Treat Options Neurol, 2014, 16(4):284-287.  doi: 10.1007/s11940-014-0284-7
[3] Mukherjee D, Sarmiento JM, Nosova K, et al. Effectiveness of radiotherapy for elderly patients with anaplastic gliomas[J]. J Clin Neurosci, 2014, 21(5):773-778.
[4] Cheng YJ, Zhao JH, Qiao WL, et al. Recent advances in diagnosis and treatment of gliomas using chlorotoxin-based bioconjugates[J]. Am J Nucl Med Mol Imaging, 2014, 4(5):385-405.
[5] 戚正武.小分子蛋白酶抑制剂及多肽毒素的研究回顾[J].科学通报, 2009, 54(18):2734-2745.
[6] DeBin JA, Maggio JE, Strichartz GR. Purification and characterization of chlorotoxin, a chloride Channel ligand from the venom of the scorpion[J]. Am J Physiol, 1993, 264(2 Pt 1):C361-C369.
[7] Mamelak AN, Jacoby DB. Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin(TM-601)[J]. Expert Opin Drug Deliv, 2007, 4(2):175- 186.
[8] Lyons SA. O′Neal J, Sontheimer H. Chlorotoxin, a scorpion-derived peptide, specifically binds to gliomas and tumors of neuroectodermal origin[J]. Glia, 2002, 39(2):162-173.  doi: 10.1002/glia.10083
[9] Qin C, He B, Dai W, et al. The impact of a chlorotoxin-modified liposome system on receptor MMP-2 and the receptor-associated protein ClC-3[J]. Biomaterials, 2014, 35(22):5908-5920.  doi: 10.1016/j.biomaterials.2014.03.077
[10] Jacoby DB, Dyskin E, Yalcin M, et al. Potent pleiotropic anti-angiogenic effects of TM601, a synthetic chlorotoxin peptide[J]. Anticancer Res, 2010, 30(1):39-46.
[11]

Shen S, Mamelak A, Raubitschek A, et al. Dosimetry of phase Ⅰ/Ⅱ study of intracavitary administered I-131-TM-601 peptide in patients with recurrent high-grade glioma[J/OL]. Int J Radiat Oncol Phys, 60(1): S259[2014-11-10]. http://academic. research. microsoft. com/Publication/30178349/dosimetry-of-phase-i-ii-study-of-intracavitary-administered-i-131tm601-peptide-in-patients-with.
[12] 许均华, 吴英亮, 罗锋, 等.蝎氯毒素结构、功能与应用研究[J].氨基酸和生物资源, 2005, 27(4):13-16.  doi: 10.3969/j.issn.1006-8376.2005.04.005
[13] Wu JJ, Dai L, Lan ZD, et al. The gene cloning and sequencing of Bm-12, a chlorotoxin-like peptide from the the scorpion Buthus martensii Karsch[J]. Toxicon, 2000, 38(5):661-668.
[14] Fu YJ, Yin LT, Wang W, et al. Synthesis, expression and purification of a type of chlorotoxin-like peptide from the scorpion, Buthus martensii Karsch, and its acute toxicity analysis[J]. Biotechnol Lett, 2005, 27(20):1597-1603.  doi: 10.1007/s10529-005-2514-2
[15] Murnyák B, Csonka T, Klekner A, et al. Occurrence and molecular pathology of low grade gliomas[J]. Ideggyógyászati Szemle, 2013, 66(9/10):305-311.
[16] Murnyák B, Csonka T, Hegyi K, et al. Occurrence and molecular pathology of high grade gliomas[J]. Ideggyogy Sz, 2013, 66(9-10):312-321.
[17] Quintero-Hernández V, Jiménez-Vargas JM, Gurrola GB, et al. Scorpion venom components that affect ion-channels function[J]. Toxicon, 2013, 76:328-342.  doi: 10.1016/j.toxicon.2013.07.012
[18] 杨锐, 彭方, 刘辉, 等.东亚钳蝎氯毒素BmKCT的表达和功能鉴定(英文)[J].中国生物化学与分子生物学报, 2005, 21(1):19-23.  doi: 10.3969/j.issn.1007-7626.2005.01.011
[19] Fu YJ, Yin LT, Liang AH, et al. Therapeutic potential of chlorotoxin-like neurotoxin from the Chinese scorpion for human gliomas[J]. Neurosci Lett, 2007, 412(1):62-67.  doi: 10.1016/j.neulet.2006.10.056
[20] Fu YJ, Yin LT, Liang AH. Polyclonal antibody against a recombinant chlorotoxin-like peptide from the Chinese scorpion and detection of its putative receptors in human glioma cells[J]. Biotechnol Lett, 2006, 28(18):1439-1443.  doi: 10.1007/s10529-006-9108-5
[21] Fu YJ, Zheng SH, Huang R, et al. A potential strategy for high-grade gliomas:combination treatment with Lithium chloride and BmK CT[J]. Biotechnol Lett, 2012, 34(1):9-17.  doi: 10.1007/s10529-011-0741-2
[22] 孙娜, 赵晋华, 乔文礼, 等. BmK CT对胶质瘤细胞侵袭的影响及机制研究[J].上海医学影像, 2012, 21(4):249-251.  doi: 10.3969/j.issn.1008-617X.2012.04.003
[23] Lippens G, Najib J, Wodak SJ, et al. NMR sequential assignments and solution structure of chlorotoxin, a small scorpion toxin that blocks chloride channels[J]. Biochemistry, 1995, 34(1):13-21.
[24] Fu YJ, An N, Chan KG, et al. A model of BmK CT in inhibiting glioma cell migration via matrix metalloproteinase-2 from experimental and molecular dynamics simulation study[J]. Biotechnol Lett, 2011, 33(7):1309-1317.  doi: 10.1007/s10529-011-0587-7
[25] Wang WX, Ji YH. Scorpion venom induces glioma cell apoptosis in vivo and inhibits glioma tumor growth in vitro[J]. J Neurooncol, 2005, 73(1):1-7.  doi: 10.1007/s11060-004-4205-6
[26] Zhao J, Qiao W, Zhang Y, et al. Preparation and in vitro evaluation of 131I-BmK CT as a glioma-targeted agent[J]. Cancer Biother Radiopharm, 2010, 25(3):353-359.  doi: 10.1089/cbr.2009.0704
[27] 乔文礼, 赵晋华, 邵晓霞, 等. 131I-BmK CT的制备及其在胶质瘤荷瘤大鼠体内分布与显像研究[J].核技术, 2011, 34(3):213-216.
[28] Fan SZ, Sun ZB, Jiang DH, et al. BmK CT toxin inhibits glioma proliferation and tumor metastasis[J]. Cancer Lett, 2010, 291(2):158-166.  doi: 10.1016/j.canlet.2009.10.011
[29]

Zou Q, Hou Y, Shen F, et al. Polarized regulation of glycogen synthase kinase-3beta is important for glioma cell invasion[J/OL]. PLoS One, 2013, 8(12): e81814.[2014-11-10]. http://www. journals.plos.org/plosone/article?id=10.1371/journal.pone.0081814.
[30] Fu YE, An N, Zheng SH, et al. BmK CT-conjugated fluorescence nanodiamond as potential glioma-targeted imaging and drug[J]. Diam Relat Mater, 2012, 21:73-76.  doi: 10.1016/j.diamond.2011.10.010
[31]

Catuogno S, Esposito CL, Quintavalle C, et al. Nucleic acids in human glioma treatment: innovative approaches and recent results[J/OL]. J Signal Transduct, 2012, 2012: 735135-735145.[2014-11-10]. http://www. hindawi. com/journals/jst/2012/735135/.
[32] Du J, Fu Y, Wang J, et al. Adenovirus-mediated expression of BmK CT suppresses growth and invasion of rat C6 glioma cells[J]. Biotechnol Lett, 2013, 35(6):861-870.  doi: 10.1007/s10529-013-1167-9
[33] Fu Y, Jiao Y, An N, et al. pEGFP-N1-mediated BmK CT expression suppresses the migration of glioma[J]. Cytotechnology, 2013, 65(4):533-539.  doi: 10.1007/s10616-012-9518-2