小胶质细胞在AD炎性机制中的作用及其常见PET显像剂的应用进展

胡伟; 赵军; 胡伟; 赵军

doi:10.3760/cma.j.issn.1673-4114.2016.01.009

[1]

Block ML, Hong JS.Microglia and inflammation-mediated neurodegeneration:multiple triggers with a common mechanism[J].Prog Neurobiol, 2005, 76(2):77-98.DOI:10.1016/j.pneurobio.2005.06.004.

[2]

Li Y, Tan MS, Jiang T, et al.Microglia in Alzheimer's disease[J/OL].Biomed Res Int, 2014, 2014: 437483[2015-07-15].http://www.hindawi.com/journals/bmri/2014/437483/.DOI:10.1155/2014/437483.

[3]

Tang Y, Le W.Differential roles of M1 and M2 microglia in neurodegenerative diseases[J/OL].Mol Neurobiol, 2015: 1-14[2015-07-15].http://www.ncbi.nlm.nih.gov/pubmed/25598354.DOI:10.1007/512035-014-9070-5.

[4]

Solito E, Sastre M.Microglia function in Alzheimer's disease[J].Frontiers in pharmacology, 2012, 3:14.DOI:10.3389/fphar.2012.00014.

[5]

Chauveau F, Boutin H, Van Camp N, et al.Nuclear imaging of neuroinflammation:a comprehensive review of[¹¹C]Pk11195 challengers[J].Eur J Nucl Med Mol Imaging, 2008, 35(12):2304-2319.DOI:10.1007/s00259-008-0908-9.

[6]

Varley J, Brooks DJ, Edison P.Imaging neuroinflammation in Alzheimer's and other dementias:Recent advances and future directions[J].Alzheimers Dement, 2015, 11(9):1110-1120.DOI:10.1016/j.jalz.2014.08.105.

[7]

Damont A, Roeda D, DolléF.The potential of carbon-11 and fluorine-18 chemistry:illustration through the development of positron emission tomography radioligands targeting the translocator protein 18 kDa[J].J Labelled Comp Radiopharm, 2013, 56(3/4):96-104.DOI:10.1002/jlcr.2992.

[8]

Shah F, Hume SP, Pike VW, et al.Synthesis of the enantiomers of[N-methyl-¹¹C]Pk 11195 and comparison of their behaviours as radioligands for Pk binding sites in rats[J].Nucl Med Biol, 1994, 21(4):573-581.

[9]

Zhang MR, Kida T, Noguchi J, et al.[¹¹C]DAA1106:radiosynthesis and in vivo binding to peripheral benzodiazepine receptors in mouse brain[J].Nucl Med Biol, 2003, 30(5):513-519.DOI:10.1016/S0969-8051(03)00016-7.

[10]

Maeda J, Suhara T, Zhang MR, et al.Novel peripheral benzodiazepine receptor ligand[¹¹C]DAA1106 for PET:an imaging tool for glial cells in the brain[J].Synapse, 2004, 52(4):283-291.DOI:10.1002/syn.20027.

[11]

Yasuno F, Kosaka J, Ota M, et al.Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment-dementia converters measured by positron emission tomography with[¹¹C] DAA1106[J].Psychiatry Res, 2012, 203(1):67-74.DOI:10.1016/j.pscychresns.2011.08.013.

[12]

Kreisl WC, Fujita M, Fujimura Y, et al.Comparison of[¹¹C]-(R)-PK 11195 and[¹¹C]PBR28, two radioligands for translocator protein(18 kDa)in human and monkey:Implications for positron emission tomographic imaging of this inflammation biomarker[J].Neuroimage, 2010, 49(4):2924-2932.DOI:10.1016/j.neuroimage.2009.11.056.

[13]

Kreisl WC, Lyoo CH, McGwier M, et al.In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease[J].Brain, 2013, 136(Pt7):2228-2238.DOI:10.1093/brain/awt145.

[14]

Librizzi L, NoèF, Vezzani A, et al.Seizure-induced brain-borne inflammation sustains seizure recurrence and blood-brain barrier damage[J].Ann Neurol, 2012, 72(1):82-90.DOI:10.1002/ana.23567.

[15]

James ML, Fulton RR, Henderson DJ, et al.Synthesis and in vivo evaluation of a novel peripheral benzodiazepine receptor PET radioligand[J].Bioorg Med Chem, 2005, 13(22):6188-6194.DOI:10.1016/j.bmc.2005.06.030.

[16]

Doorduin J, Klein HC, Dierckx RA, et al.[¹¹C]-DPA-713 and[¹⁸F]-DPA-714 as new PET tracers for TSPO:a comparison with[¹¹C]-(R)-PK11195 in a rat model of herpes encephalitis[J].Mol Imaging Biol, 2009, 11(6):386-398.DOI:10.1007/s11307-009-0211-6.

[17]

Boutin H, Chauveau F, Thominiaux C, et al.¹¹C-DPA-713:a novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation[J].J Nucl Med, 2007, 48(4):573-581.DOI:10.2967/jnumed.106.036764.

[18]

Endres CJ, Pomper MG, James M, et al.Initial evaluation of ¹¹C-DPA-713, a novel TSPO PET ligand, in humans[J].J Nucl Med, 2009, 50(8):1276-1282.DOI:10.2967/jnumed.109.062265.

[19]

James ML, Fulton RR, Vercoullie J, et al.DPA-714, a new translocator protein-specific ligand:Synthesis, radiofluorination, and pharmacologic characterization[J].J Nucl Med, 2008, 49(5):814-822.DOI:10.2967/jnumed.107.046151.

[20]

Chauveau F, Van Camp N, DolléF, et al.Comparative evaluation of the translocator protein radioligands ¹¹C-DPA-713, ¹⁸F-DPA-714, and ¹¹C-PK11195 in a rat model of acute neuroinflammation[J].J Nucl Med, 2009, 50(3):468-476.DOI:10.2967/jnumed.108.058669.

[21]

Arlicot N, Vercouillie J, Ribeiro MJ, et al.Initial evaluation in healthy humans of[¹⁸F]DPA-714, a potential PET biomarker for neuroinflammation[J].Nucl Med Biol, 2012, 39(4):570-578.DOI:10.1016/j.nucmedbio.2011.10.012.

[22]

Golla SS, Boellaard R, Oikonen V, et al.Quantification of[¹⁸F]DPA-714 binding in the human brain:initial studies in healthy controls and Alzheimer's disease patients[J].J Cereb Blood Flow Metab, 2015, 35(5):766-772.DOI:10.1038/jcbfm.2014.261.

[23]

Chaki S, Funakoshi T, Yoshikawa R, et al.Binding characteristics of[³H] DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors[J].Eur J Pharmacol, 1999, 371(2):197-204.

[24]

Zhang MR, Maeda J, Furutsuka K, et al.[¹⁸F]FMDAA1106 and[¹⁸F]FEDAA1106:two positron-emitter labeled ligands for peripheral benzodiazepine receptor(PBR)[J].Bioorg Med Chem Lett, 2003, 13(2):201-204.DOI:10.1016/1s0960-894x(02)00886-7.

[25]

Zhang MR, Maeda J, Ogawa M, et al.Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[¹⁸F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain[J].J Med Chem, 2004, 47(9):2228-2235.DOI:10.1021/jm0304919.

[26]

Takano A, Gulyás B, Varrone A, et al.Biodistribution and radiation dosimetry of the 18 kDa translocator protein(TSPO)radioligand[¹⁸F] FEDAA1106:a human whole-body PET study[J].Eur J Nucl Med Mol imaging, 2011, 38(11):2058-2065.DOI:10.1007/s00259-011-1864-3.

[27]

Varrone A, Mattsson P, Forsberg A, et al.In vivo imaging of the 18-kDa translocator protein(TSPO)with[¹⁸F]FEDAA1106 and PET does not show increased binding in Alzheimer's disease patients[J].Eur J Nucl Med Mol Imaging, 2013, 40(6):921-931.DOI:10.1007/s00259-013-2359-1.

[28]

Fookes CJ, Pham TQ, Mattner F, et al.Synthesis and biological evaluation of substituted[¹⁸F]imidazo[1, 2-a]pyridines and[¹⁸F]pyrazolo[1, 5-a]pyrimidines for the study of the peripheral benzodiazepine receptor using positron emission tomography[J].J Med Chem, 2008, 51(13):3700-3712.DOI:10.1021/jm7014556.

[29]

Van Camp N, Boisgard R, Kuhnast B, et al.In vivo imaging of neuroinflammation:a comparative study between[¹⁸F] PBR111, [¹¹C] CLINME and[¹¹C] PK11195 in an acute rodent model[J].Eur J Nucl Med Mol imaging, 2010, 37(5):962-972.DOI:10.1007/s00259-009-1353-0.

[30]

Verschuer JD, Towson J, Eberl S, et al.Radiation dosimetry of the translocator protein ligands[¹⁸F] PBR111 and[¹⁸F] PBR102[J].Nucl Med Biol, 2012, 39(5):742-753.DOI:10.1016/j.hucmodbio.2011.11.003.

[31]

Guo Q, Colasanti A, Owen DR, et al.Quantification of the specific translocator protein signal of ¹⁸F-PBR111 in healthy humans:a genetic polymorphism effect on in vivo binding[J].J Nucl Med, 2013, 54(11):1915-1923.DOI:10.2967/jnumed.113.121020.

[32]

Kuhnast B, Damont A, Hinnen F, et al.[¹⁸F]DPA-714, [¹⁸F]PBR111 and[¹⁸F] FEDAA1106-selective radioligands for imaging TSPO 18 kDa with PET:automated radiosynthesis on a TRACERLAb FX-FN synthesizer and quality controls[J].Appl Radiat Isot, 2012, 70(3):489-497.DOI:10.1016/j.apradiso.2011.10.015.

[33]

James ML, Belichenko NP, Nguyen TVV, et al.PET Imaging of translocator protein(18 kDa) in a mouse model of Alzheimer's disease using N-(2, 5-dimethoxybenzyl)-2-¹⁸F-Fluoro-N-(2-Phenoxyphenyl)acetamide[J].J Nucl Med, 2015, 56(2):311-316.DOI:10.2967/jnumed.114.141648.

[34]

Suridjan I, Rusjan PM, Voineskos AN, et al.Neuroinflammation in healthy aging:A PET study using a novel Translocator Protein 18kDa(TSPO)radioligand, [¹⁸F]-FEPPA[J].Neuroimage, 2014, 84:868-875.DOI:10.1016/j.neuroimage.2013.09.021.

[35]

Benito C, Tolon RM, Pazos MR, et al.Cannabinoid CB2 receptors in human brain inflammation[J].Br J Pharmacol, 2008, 153(2):277-285.DOI:10.1038/sj.bjp.0707505.