[1] Castro MG, Cowen R, Wiiliamson IK, et al. Current and future strategies for the treatment of malignant brain tumors[J]. Pharmac Therapeutics, 2003, 98(1):71-108.
[2] Yount GL, Afshar G, Ries S, et al. Transcriptional activation of TRADD mediates p53-independent radiation-induced apoptosis of glioma ceils[J]. Oncogene, 2001, 20(22):2826-2835.
[3] 翟中, 王喜忠, 丁明孝等.细胞生物学[M].北京:高等教育出版社,2000,464.
[4] Tomita M, Suzuki N, Matsumoto Y, et al. Sensitization by wortmannin of heat- or X-ray induced cell death in cultured Chinese hamster V79 cells[J]. J Radiat Re, 2000, 41(2):93-102.
[5] Cataldi A, Zauli G, Di Pietro R, et al. Involvement of the pathway phosphatidylinositol-3-kinase/AKT-1 in the establishment of the survival response to ionizing radiation[J]. Cell Signall, 2001, 13(5):369-375.
[6] Tachiiri S, Sasai K, Oya N, et al. Enhanced cell killing by overexpression of dominant-negative phosphatidylinositol 3-kinase subunit, Deltap85, following genotoxic stresses[J]. Japan J Cancer Res, 2000, 91(12):1314-1318.
[7] Edwards E, Geng L, Tan J, et al. Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation[J]. Cancer Res, 2002, 62(16):4671-4677.
[8] Wickremasinghe RG, Ganeshaguru K, Jones DT, et al. Autologous plasma activates Akt/protein kinase B and enhances basal survival and resistance to DNA damage-induced apoptesis in B-chronic lymphocytic leukaemia cells[J]. Br J Haematol, 2001, 114(3):608-615.
[9] Jones DT, Ganeshaguru K, Anderson R J, et al. Albumin activates the AKT signaling pathway and protects B-chronic lymphocytic leukemia cells from chlormnbucil and radiation-induced apoptosis[J]. Blood, 2003, 101(8):3174-3180.
[10] Cataldi A, Di Pietro R, Centurione L, et al. Engagement of PI-3-kinase mediated protein kinase C zeta activation in protecting Friend cells from ionizing radiation-induced apoptosis[J]. Int J Oncol, 2003, 22(1):129-135.
[11] Ibuki Y, Goto R. Suppression of apoptosis by UVB irradiation:survival signaling via PI3-kinase/Akt pathway[J]. Biochem & Biophys Res Commun, 2000, 279(3):872-878.
[12] Wan YS, Wang ZQ, Shao Y, et al. Ultraviolet irradiation activates PI 3-kinase/AKT survival pathway via EGF receptors in human skin in vivo[J]. Int J Oncol, 2001, 18(3):461-466.
[13] Zhang QS, Maddock DA, Chen JP, et al. Cytokine-indueed p38 activation feedback regulates the prolonged activation of AKT cell survival pathway initiated by reactive oxygen species in response to UV irradiation in human keratinocytes[J]. Int J Oneol,2001.19(5):1057-1061.
[14] Umeda J, Sano S, Kogawa K, et al. In vivo cooperation between Bcl-xL and the phosphoinositide 3-kinase-Akt signaling pathway for the protection of epidermal kerafinoeytes from apoptosis[J].FASEB J, 2003, 17(6):610-620.
[15] Dunn IF, Heese O, Black PM, et al. Growth factors in glioma angiogenesis:FGFs, PDGF, EGF and TGFs[J]. J Neuro Oncol, 2000,50(1-2):121-137.
[16] 周颖奇,王智巍,王承,等.中国人胶质瘤中表皮生长因子受体基因的扩增及对患者预后的影响[J].中华神经外科杂志,2003,19(1):26-29.
[17] Chakravarti A, Loeffler JS, Dyson N J, et al. Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling[J]. Cancer Res, 2002, 62(1):200-207.
[18] Chakravarti A, Chakladar A, Delaney MA, et al. The epidermal growth factor receptor pathway mediates resistance to sequential administration of radiation and chemotherapy in primary human glioblastoma cells in a RAS-dependent manner[J]. Cancer Res,2002, 62(15):4307-4315.
[19] Gomez Del Pulgar T, De Ceballos ML. Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathway[J]. J Biol Chem, 2002,277(39):36527-36533.
[20] Alphonse G, Aloy MT, Broquet P, et al. Ceramide induces activation of the mitochondrial/caspases pathway in Jurkat and SCC61 cells sensitive to gamma-radiation but activation of this sequence is defective in radioresistant SQ20B ceils[J]. Int J Radiat Biol, 2002,78(9):821-835.
[21] Michael JM, Lavin MF, Watters DJ, et al. Resistance to radiation-induced apoptosis in Burki's lymphoma cells is associated with defective ceramide signaling[J]. Cancer Res, 1997, 57(16):3600-3605.
[22] Kubota N, Okada S, Inada T, et al. Wortmannin sensitizes human glioblastoma cell lines carrying mutant and wild type TP53 gene to radiation[J]. Cancer Letter, 2000, 161(2):141-147.
[23] Okada S, Ono K, Hamada N, et al. A low-pH culture condition enhances the radiosensitizing effect of wortmannin[J], Int J Ⅱ JRadiat Oncol Biol Phys, 2001, 49(4):1149-1156.
[24] Okaichi K, Suzuki K, Morita N, et al. Low dose of wortmannin reduces radiosensitivity of human glioblastoma cells through the p53 pathway[J]. Oncol Report, 2002, 9(4):859-862.