[1] 张海澄, 郭继鸿.冠心病流行病学与一级预防.中国实用内科杂志, 2002, 22(8): 449-451.
[2] 吴锡桂.我国人群冠心病流行现况与趋势.中国慢性病预防与控制, 2003, 11(4): 190-191.
[3] 刘小清.冠心病流行病学研究进展及疾病负担.中华心血管病杂志, 2008, 36(6): 573-576.
[4] Taimeh Z, Loughran J, Birks EJ, et al. Vascular endothelial growth factor in heart failure. Nat Rev Cardiol, 2013, 10(9): 519-530.
[5] Woolard J, Bevan HS, Harper SJ, et al. Molecular diversity of VEGF-A as a regulator of its biological activity. Microcirculation, 2009, 16(7): 572-592.
[6] Zhao T, Zhao W, Chen Y, et al. Vascular endothelial growth factor(VEGF)-A: role on cardiac angiogenesis following myocardial infarction. Microvasc Res, 2010, 80(2): 188-194.
[7] Nam JO, Son HN, Jun E, et al. FAS1 domain protein inhibits VEGF165-induced angiogenesis by targeting the interaction between VEGFR-2 and αvβ3 integrin. Mol Cancer Res, 2012, 10(8): 1010-1020.
[8] Ruixing Y, Jiaquan L, Jie C, et al. Intravenous administration of vascular endothelial growth factor improves cardiac performance and inhibits cardiomyocyte apoptosis. Growth Factors, 2006, 24(3): 209-217.
[9] Hao X, Månsson-Broberg A, Grinnemo KH, et al. Myocardial angiogenesis after plasmid or adenoviral VEGF-A165 gene transfer in rat myocardial infarction model. Cardiovasc Res, 2007, 73(3): 481-487.
[10] Yan D, Wang X, Li D, et al. Macrophages overexpressing VEGF target to infarcted myocardium and improve neovascularization and cardiac function. Int J Cardiol, 2013, 164(3): 334-338.
[11] Morishita R, Aoki M, Yo Y, et al. Hepatocyte growth factor as cardiovascular hormone: role of HGF in the pathogenesis of cardiovascular disease. Endocr J, 2002, 49(3): 273-284.
[12]

Salimath AS, Phelps EA, Boopathy AV, et al. Dual delivery of hepatocyte and vascular endothelial growth factors via a protease-degradable hydrogel improves cardiac function in rats[J/OL]. PLoS One, 2012, 7(11): e50980[2012-12-24]. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0050980.
[13]

Paradiso B, Zucchini S, Simonato M. Implication of fibroblast growth factors in epileptogenesis-associated circuit rearrangements[J/OL]. Front Cell Neurosci, 2013, 7: 1-9[2012-12-24]. http://www.readcube.com/articles/10.3389/fncel.2013.00152.
[14] Gao MH, Lai NC, McKirnan MD, et al. Increased regional function and perfusion after intracoronary delivery of adenovirus encoding fibroblast growth factor 4: report of preclinical data. Hum Gene Ther, 2004, 15(6): 574-587.
[15] Suzuki G, Lee TC, Fallavollita JA, et al. Adenoviral gene transfer of FGF-5 to hibernating myocardium improves function and stimulates myocytes to hypertrophy and reenter the cell cycle. Circ Res, 2005, 96(7): 767-775.
[16] McCarter SD, Mei SH, Lai PF, et al. Cell-based angiopoietin-1 gene therapy for acute lung injury. Am J Respir Crit Care Med, 2007, 175(10): 1014-1026.
[17]

Mei SH, McCarter SD, Deng Y, et al. Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1[J/OL]. PLoS Med, 2007, 4(9): e269[2012-12-24]. http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.0040269.
[18] 朱成楚, 陈仕林, 刘玉清, 等. rAAV2VEGF165与rAAV2ANG-1联合转染促猪缺血心肌血管生成的研究.浙江大学学报:医学版, 2010, 39(6): 610-617.
[19] 黄盛东, 刘晓红, 白辰光, 等.重组腺病毒介导的血管生成素改善缺血性心脏病的实验研究.中华老年心脑血管病杂志, 2007, 9(3): 192-195.
[20] 王潇, 陈茜, 周青, 等. SonoVue微泡介导转染Ang-1基因治疗急性心肌梗死.中国医学影像技术, 2009, 25(11): 1969-1971.
[21] Tuo QH, Xiong GZ, Zeng H, et al. Angiopoietin-1 protects myocardial endothelial cell function blunted by angiopoietin-2 and high glucose condition. Acta pharmacol Sin, 2011, 32(1): 45-51.
[22] Tao Z, Chen B, Tan X, et al. Coexpression of VEGF and angiopoietin-1 promotes angiogenesis and cardiomyocyte proliferation reduces apoptosis in porcine myocardial infarction(MI)heart. Proc Natl Acad Sci U S A, 2011, 108(5): 2064-2069.
[23] Yuan G, Peng YJ, Reddy VD, et al. Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis. Proc Natl Acad Sci U S A. 2013, 110(19): E1788-1796.
[24] D'Angelo G, Duplan E, Boyer N, et al. Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation. J Biol Chem, 2003, 278(40): 38183-38187.
[25] Wang GL, Jiang BH, Rue EA, et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A. 1995, 92(12): 5510-5514.
[26] Manalo DJ, Rowan A, Lavoie T, et al. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood, 2005, 105(2): 659-669.
[27]

Semenza GL. Hypoxia-inducible factor 1(HIF-1) pathway[J/OL]. Sci STKE, 2007, 2007(407): cm8[2012-12-24]. http://stke.sciencemag.org/cgi/content/abstract/2007/407/cm8.
[28] Brahimi-Horn C, Pouysségur J. The role of the hypoxia-inducible factor in tumor metabolism growth and invasion. Bull Cancer, 2006, 93(8): E73-80.
[29] Hinkel R, Lebherz C, Fydanaki M, et al. Angiogenetic potential of Ad2/Hif-1α/VP16 after regional application in a preclinical pig model of chronic ischemia. Curr Vasc Pharmacol. 2013, 11(1): 29-37.
[30]

牛铁生.缺氧诱导因子1对大鼠心肌梗死及再灌注损伤的保护作用研究.沈阳: 中国医科大学, 2007.
[31] Huang Y, Hickey RP, Yeh JL, et al. Cardiac myocyte-specific HIF-1α deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart. FASEB J. 2004, 18(10): 1138-1140.
[32] Vale PR, Losordo DW, Milliken CE, et al. Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electromechanical mapping in patients with chronic myocardial ischemia. Circulation, 2001, 103(17): 2138-2143.
[33] Shyu KG, Wang MT, Wang BW, et al. Intramyocardial injection of naked DNA encoding HIF-1α/VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat. Cardiovasc Res, 2002, 54(3): 576-583.
[34] Dong F, Khalil M, Kiedrowski M, et al. Critical role for leukocyte hypoxia inducible factor-1α expression in post-myocardial infarction left ventricular remodeling. Circ Res, 2010, 106(3): 601-610.