[1] Hamson EJ, Keane FM, Tholen S, et al.  Understanding fibroblast activation protein (FAP): substrates, activities, expression and targeting for cancer therapy[J]. Proteomics Clin Appl, 2014, 8(5/6): 454-463.   doi: 10.1002/prca.201300095
[2] 高媛, 武越歆, 韩莹莹, 等.  细胞外基质与肿瘤相关成纤维细胞[J]. 生物化学与生物物理进展, 2017, 44(8): 660-671.   doi: 10.16476/j.pibb.2017.0251
Gao Y, Wu YX, Han YY, et al.  Extracellular matrix and cancer-associated fibroblasts[J]. Prog Biochem Biophys, 2017, 44(8): 660-671.   doi: 10.16476/j.pibb.2017.0251
[3] Zi FM, He JS, He DH, et al.  Fibroblast activation protein α in tumor microenvironment: recent progression and implications (review)[J]. Mol Med Rep, 2015, 11(5): 3203-3211.   doi: 10.3892/mmr.2015.3197
[4]

Koustoulidou S, Hoorens MWH, Dalm SU, et al. Cancer-associated fibroblasts as players in cancer development and progression and their role in targeted radionuclide imaging and therapy[J/OL]. Cancers, 2021, 13(5): 1100[2022-03-22]. https://www.mdpi.com/2072-6694/13/5/1100. DOI: 10.3390/cancers13051100.

[5] Welt S, Divgi CR, Scott AM, et al.  Antibody targeting in metastatic colon cancer: a phase I study of monoclonal antibody F19 against a cell-surface protein of reactive tumor stromal fibroblasts[J]. J Clin Oncol, 1994, 12(6): 1193-1203.   doi: 10.1200/JCO.1994.12.6.1193
[6]

Pandya DN, Sinha A, Yuan H, et al. Imaging of fibroblast activation protein alpha expression in a preclinical mouse model of glioma using positron emission tomography[J/OL]. Molecules, 2020, 25(16): 3672[2022-03-22]. https://www.mdpi.com/1420-3049/25/16/3672. DOI: 10.3390/molecules25163672.

[7] Hintz HM, Gallant JP, Vander Griend DJ, et al.  Imaging fibroblast activation protein alpha improves diagnosis of metastatic prostate cancer with positron emission tomography[J]. Clin Cancer Res, 2020, 26(18): 4882-4891.   doi: 10.1158/1078-0432.CCR-20-1358
[8] Loktev A, Lindner T, Mier W, et al.  A tumor-imaging method targeting cancer-associated fibroblasts[J]. J Nucl Med, 2018, 59(9): 1423-1429.   doi: 10.2967/jnumed.118.210435
[9] Lindner T, Loktev A, Altmann A, et al.  Development of quinoline-based theranostic ligands for the targeting of fibroblast activation protein[J]. J Nucl Med, 2018, 59(9): 1415-1422.   doi: 10.2967/jnumed.118.210443
[10] Loktev A, Lindner T, Burger EM, et al.  Development of fibroblast activation protein-targeted radiotracers with improved tumor retention[J]. J Nucl Med, 2019, 60(10): 1421-1429.   doi: 10.2967/jnumed.118.224469
[11]

Moon ES, Elvas F, Vliegen G, et al. Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA5m chelators[J/OL]. EJNMMI Radiopharm Chem, 2020, 5(1): 19[2022-03-22]. https://ejnmmipharmchem.springeropen.com/articles/10.1186/s41181-020-00102-z. DOI: 10.1186/s41181-020-00102-z.

[12] Zhao L, Niu B, Fang JY, et al.  Synthesis, preclinical evaluation, and a pilot clinical PET imaging study of 68Ga-labeled FAPI dimer[J]. J Nucl Med, 2022, 63(6): 862-868.   doi: 10.2967/jnumed.121.263016
[13]

Lindner T, Altmann A, Giesel F, et al. 18F-labeled tracers targeting fibroblast activation protein[J/OL]. EJNMMI Radiopharm Chem, 2021, 6(1): 26[2022-03-22]. https://ejnmmipharmchem.springeropen.com/articles/10.1186/s41181-021-00144-x. DOI: 10.1186/s41181-021-00144-x.

[14] Toms J, Kogler J, Maschauer S, et al.  Targeting fibroblast activation protein: radiosynthesis and preclinical evaluation of an 18F-labeled FAP inhibitor[J]. J Nucl Med, 2020, 61(12): 1806-1813.   doi: 10.2967/jnumed.120.242958
[15] Wang SL, Zhou X, Xu XX, et al.  Clinical translational evaluation of Al18F-NOTA-FAPI for fibroblast activation protein-targeted tumour imaging[J]. Eur J Nucl Med Mol Imaging, 2021, 48(13): 4259-4271.   doi: 10.1007/s00259-021-05470-5
[16] Hu KZ, Wang LJ, Wu HB, et al.  [18F]FAPI-42 PET imaging in cancer patients: optimal acquisition time, biodistribution, and comparison with [68Ga]Ga-FAPI-04[J]. Eur J Nucl Med Mol Imaging, 2022, 49(8): 2833-2843.   doi: 10.1007/s00259-021-05646-z
[17] Hu KZ, Li JQ, Wang LJ, et al.  Preclinical evaluation and pilot clinical study of [18F]AlF-labeled FAPI-tracer for PET imaging of cancer associated fibroblasts[J]. Acta Pharm Sin B, 2022, 12(2): 867-875.   doi: 10.1016/j.apsb.2021.09.032
[18]

Huang JW, Fu LL, Hu KZ, et al. Automatic production and preliminary PET imaging of a new imaging agent [18F]AlF-FAPT[J/OL]. Front Oncol, 2022, 11: 802676[2022-03-22]. https://www.frontiersin.org/articles/10.3389/fonc.2021.802676/full. DOI: 10.3389/fonc.2021.802676.

[19] Watabe T, Liu YW, Kaneda-Nakashima K, et al.  Theranostics targeting fibroblast activation protein in the tumor stroma: 64Cu- and 225Ac-labeled FAPI-04 in pancreatic cancer xenograft mouse models[J]. J Nucl Med, 2020, 61(4): 563-569.   doi: 10.2967/jnumed.119.233122
[20]

Langer LBN, Hess A, Korkmaz Z, et al. Molecular imaging of fibroblast activation protein after myocardial infarction using the novel radiotracer [68Ga]MHLL1[J/OL]. Theranostics, 2021, 11(16): 7755−7766[2022-03-22]. https://www.thno.org/v11p7755.htm. DOI: 10.7150/thno.51419.

[21] Baum RP, Schuchardt C, Singh A, et al.  Feasibility, biodistribution, and preliminary dosimetry in peptide-targeted radionuclide therapy of diverse adenocarcinomas using 177Lu-FAP-2286: first-in-humans results[J]. J Nucl Med, 2022, 63(3): 415-423.   doi: 10.2967/jnumed.120.259192
[22] Chen HJ, Pang YZ, Wu JX, et al.  Comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F] FDG PET/CT for the diagnosis of primary and metastatic lesions in patients with various types of cancer[J]. Eur J Nucl Med Mol Imaging, 2020, 47(8): 1820-1832.   doi: 10.1007/s00259-020-04769-z
[23] Lan LJ, Liu HX, Wang YW, et al.  The potential utility of [68Ga]Ga-DOTA-FAPI-04 as a novel broad-spectrum oncological and non-oncological imaging agent—comparison with [18F]FDG[J]. Eur J Nucl Med Mol Imaging, 2022, 49(3): 963-979.   doi: 10.1007/s00259-021-05522-w
[24]

Hathi DK, Jones EF. 68Ga FAPI PET/CT: tracer uptake in 28 different kinds of cancer[J/OL]. Radiol Imaging Cancer, 2019, 1(1): e194003[2022-03-22]. https://pubs.rsna.org/doi/10.1148/rycan.2019194003. DOI: 10.1148/rycan.2019194003.

[25] Chen HJ, Zhao L, Ruan D, et al.  Usefulness of [68Ga]Ga-DOTA-FAPI-04 PET/CT in patients presenting with inconclusive [18F]FDG PET/CT findings[J]. Eur J Nucl Med Mol Imaging, 2021, 48(1): 73-86.   doi: 10.1007/s00259-020-04940-6
[26] Ballal S, Yadav MP, Moon ES, et al.  Biodistribution, pharmacokinetics, dosimetry of [68Ga]Ga-DOTA. SA. FAPi, and the head-to-head comparison with [18F]F-FDG PET/CT in patients with various cancers[J]. Eur J Nucl Med Mol Imaging, 2021, 48(6): 1915-1931.   doi: 10.1007/s00259-020-05132-y
[27] Röhrich M, Loktev A, Wefers AK, et al.  IDH-wildtype glioblastomas and grade Ⅲ/Ⅳ IDH-mutant gliomas show elevated tracer uptake in fibroblast activation protein-specific PET/CT[J]. Eur J Nucl Med Mol Imaging, 2019, 46(12): 2569-2580.   doi: 10.1007/s00259-019-04444-y
[28] Röhrich M, Floca R, Loi L, et al.  FAP-specific PET signaling shows a moderately positive correlation with relative CBV and no correlation with ADC in 13 IDH wildtype glioblastomas[J]. Eur J Radiol, 2020, 127: 109021-.   doi: 10.1016/j.ejrad.2020.109021
[29] Syed M, Flechsig P, Liermann J, et al.  Fibroblast activation protein inhibitor (FAPI) PET for diagnostics and advanced targeted radiotherapy in head and neck cancers[J]. Eur J Nucl Med Mol Imaging, 2020, 47(12): 2836-2845.   doi: 10.1007/s00259-020-04859-y
[30] Wang LJ, Tang GH, Hu KZ, et al.  Comparison of 68Ga-FAPI and 18F-FDG PET/CT in the evaluation of advanced lung cancer[J]. Radiology, 2022, 303(1): 191-199.   doi: 10.1148/radiol.211424
[31] Giesel FL, Adeberg S, Syed M, et al.  FAPI-74 PET/CT using either 18F-AlF or cold-kit 68Ga labeling: biodistribution, radiation dosimetry, and tumor delineation in lung cancer patients[J]. J Nucl Med, 2021, 62(2): 201-207.   doi: 10.2967/jnumed.120.245084
[32] Li YC, Lin XQ, Li Y, et al.  Clinical utility of f-18 labeled fibroblast activation protein inhibitor (FAPI) for primary staging in lung adenocarcinoma: a prospective study[J]. Mol Imaging Biol, 2022, 24(2): 309-320.   doi: 10.1007/s11307-021-01679-w
[33] Ristau J, Giesel FL, Haefner MF, et al.  Impact of primary staging with fibroblast activation protein specific enzyme inhibitor (FAPI)-PET/CT on radio-oncologic treatment planning of patients with esophageal cancer[J]. Mol Imaging Biol, 2020, 22(6): 1495-1500.   doi: 10.1007/s11307-020-01548-y
[34] Pang YZ, Zhao L, Luo ZM, et al.  Comparison of 68Ga-FAPI and 18F-FDG uptake in gastric, duodenal, and colorectal cancers[J]. Radiology, 2021, 298(2): 393-402.   doi: 10.1148/radiol.2020203275
[35] Koerber SA, Staudinger F, Kratochwil C, et al.  The role of 68Ga-FAPI PET/CT for patients with malignancies of the lower gastrointestinal tract: first clinical experience[J]. J Nucl Med, 2020, 61(9): 1331-1336.   doi: 10.2967/jnumed.119.237016
[36] Shi XM, Xing HQ, Yang XB, et al.  Fibroblast imaging of hepatic carcinoma with 68Ga-FAPI-04 PET/CT: a pilot study in patients with suspected hepatic nodules[J]. Eur J Nucl Med Mol Imaging, 2021, 48(1): 196-203.   doi: 10.1007/s00259-020-04882-z
[37] Shi XM, Xing HQ, Yang XB, et al.  Comparison of PET imaging of activated fibroblasts and 18F-FDG for diagnosis of primary hepatic tumours: a prospective pilot study[J]. Eur J Nucl Med Mol Imaging, 2021, 48(5): 1593-1603.   doi: 10.1007/s00259-020-05070-9
[38] Röhrich M, Naumann P, Giesel FL, et al.  Impact of 68Ga-FAPI PET/CT imaging on the therapeutic management of primary and recurrent pancreatic ductal adenocarcinomas[J]. J Nucl Med, 2021, 62(6): 779-786.   doi: 10.2967/jnumed.120.253062
[39] Kömek H, Can C, Güzel Y, et al.  68Ga-FAPI-04 PET/CT, a new step in breast cancer imaging: a comparative pilot study with the 18F-FDG PET/CT[J]. Ann Nucl Med, 2021, 35(6): 744-752.   doi: 10.1007/s12149-021-01616-5
[40] Dendl K, Koerber SA, Finck R, et al.  68Ga-FAPI-PET/CT in patients with various gynecological malignancies[J]. Eur J Nucl Med Mol Imaging, 2021, 48(12): 4089-4100.   doi: 10.1007/s00259-021-05378-0
[41] Elboga U, Sahin E, Kus T, et al.  Superiority of 68Ga-FAPI PET/CT scan in detecting additional lesions compared to 18FDG PET/CT scan in breast cancer[J]. Ann Nucl Med, 2021, 35(12): 1321-1331.   doi: 10.1007/s12149-021-01672-x
[42] Kessler L, Ferdinandus J, Hirmas N, et al.  68Ga-FAPI as a diagnostic tool in sarcoma: data from the 68Ga-FAPI PET prospective observational trial[J]. J Nucl Med, 2022, 63(1): 89-95.   doi: 10.2967/jnumed.121.262096
[43] Koerber SA, Finck R, Dendl K, et al.  Novel FAP ligands enable improved imaging contrast in sarcoma patients due to FAPI-PET/CT[J]. Eur J Nucl Med Mol Imaging, 2021, 48(12): 3918-3924.   doi: 10.1007/s00259-021-05374-4
[44] Tillmanns J, Hoffmann D, Habbaba Y, et al.  Fibroblast activation protein alpha expression identifies activated fibroblasts after myocardial infarction[J]. J Mol Cell Cardiol, 2015, 87: 194-203.   doi: 10.1016/j.yjmcc.2015.08.016
[45] Varasteh Z, Mohanta S, Robu S, et al.  Molecular imaging of fibroblast activity after myocardial infarction using a 68Ga-labeled fibroblast activation protein inhibitor, FAPI-04[J]. J Nucl Med, 2019, 60(12): 1743-1749.   doi: 10.2967/jnumed.119.226993
[46] Heckmann MB, Reinhardt F, Finke D, et al.  Relationship between cardiac fibroblast activation protein activity by positron emission tomography and cardiovascular disease[J]. Circ Cardiovasc Imaging, 2020, 13(9): e010628-.   doi: 10.1161/CIRCIMAGING.120.010628
[47] Siebermair J, Köhler MI, Kupusovic J, et al.  Cardiac fibroblast activation detected by Ga-68 FAPI PET imaging as a potential novel biomarker of cardiac injury/remodeling[J]. J Nucl Cardiol, 2021, 28(3): 812-821.   doi: 10.1007/s12350-020-02307-w
[48] Luo YP, Pan QQ, Yang HX, et al.  Fibroblast activation protein-targeted PET/CT with 68Ga-FAPI for imaging IgG4-related disease: comparison to 18F-FDG PET/CT[J]. J Nucl Med, 2021, 62(2): 266-271.   doi: 10.2967/jnumed.120.244723
[49] Schmidkonz C, Rauber S, Atzinger A, et al.  Disentangling inflammatory from fibrotic disease activity by fibroblast activation protein imaging[J]. Ann Rheum Dis, 2020, 79(11): 1485-1491.   doi: 10.1136/annrheumdis-2020-217408
[50] Xu TT, Zhao Y, Ding HY, et al.  [68Ga]Ga-DOTA-FAPI-04 PET/CT imaging in a case of prostate cancer with shoulder arthritis[J]. Eur J Nucl Med Mol Imaging, 2021, 48(4): 1254-1255.   doi: 10.1007/s00259-020-05028-x
[51] Lindner T, Altmann A, Krämer S, et al.  Design and development of 99mTc-labeled FAPI tracers for SPECT imaging and 188Re therapy[J]. J Nucl Med, 2020, 61(10): 1507-1513.   doi: 10.2967/jnumed.119.239731
[52] Ballal S, Yadav MP, Moon ES, et al.  Novel fibroblast activation protein inhibitor-based targeted theranostics for radioiodine-refractory differentiated thyroid cancer patients: a pilot study[J]. Thyroid, 2022, 32(1): 65-77.   doi: 10.1089/thy.2021.0412