Abstract: In recent years, targeted protein degradation(TPD) technology, as an emerging therapeutic strategy, has attracted widespread attention for its development. This technology degrades target proteins by constructing targeting chimeras that exploit intracellular lysosomal and proteasomal pathways. Molecular imaging techniques enable rapid and continuous monitoring and assessment of target protein expression, greatly facilitating TPD research. This article briefly introduces TPD technology and reviews the progress in the application of molecular imaging techniques, including optical imaging, MRI, PET, and reporter gene imaging, in the field of TPD.